Effect of body mass index on peak growth hormone level after growth hormone stimulation test in children with short stature

Lee, Na Young; Kim, Sung Eun; Kim, Seul-Ki; Ahn, Myeong Im; Kim, Shin Hee; Cho, Won Kyung; Jung, Min Ho; Suh, Byung‐Kyu

doi:10.6065/apem.2040246.123

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…A negative correlation between peak GH levels and BMI in GHD is documented earlier as well and is postulated to impair GH response in children with GHD. [ 17 , 18 ]As per a meta-analysis, a per unit increase in BMI decreases the peak GH level by 11.6%. [ 17 ] These findings suggest that there is a need for BMI SDS-specific peak GH cut-off on GHST.…”

Section: Discussionmentioning

confidence: 99%

Pragmatic Evaluation of Growth Hormone Stimulation Tests in Short Stature

Gupta,

Dabas,

Kohli

et al. 2024

Indian Journal of Endocrinology and Metabolism

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Introduction: To assess the performance of growth hormone stimulation tests (GHSTs) in the evaluation of short stature. Methods: It was a single-centre retrospective study carried out in children evaluated for short stature between January 2005 to March 2020. The clonidine stimulation test (CST) and glucagon stimulation test (GST) were used to assess growth hormone (GH) reserve (GST was performed only when peak GH levels were between 5 to ≤10 ng/mL on CST). A GH level of <5 ng/mL on CST or ≤10 ng/ml on both was used to corroborate GH deficiency. Results: A total of 556 children were eligible for this study. The mean (SD) age was 12.9 (3.5) years, and 66.3% were male. The peak GH level [median (IQR)] was 5.50 ng/ml (1.90 – 7.50) on CST (at 60 minutes) and 7.45 ng/ml (2.15 – 10.77) on GST (at 120 minutes). On restricting sampling to two time points, the false positive rate was 13.6% on CST (60, 90 minutes) and 11.5% on GST (120, 150 minutes). Similarly, restricting to three time points was associated with a false positive rate of 8.5% on CST (60, 90, 120 minutes) and 3.8% on GST (90, 120, 150 minutes). Using the treating clinician-determined diagnosis of GHD as a reference standard, the optimal cut-off of peak GH on CST was 7.79 ng/ml (sensitivity: 83.8%; specificity: 89.4%). Conclusion: Restricting the GH sampling to fewer time points is associated with an increase in the false positivity rate (FPR).

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Section: Discussionmentioning

confidence: 99%

Pragmatic Evaluation of Growth Hormone Stimulation Tests in Short Stature

Gupta,

Dabas,

Kohli

et al. 2024

Indian Journal of Endocrinology and Metabolism

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“…The GH response to pharmacological stimulation varies with the stimulant type, state of GH secretion preceding the stimulus, age, puberty, and other physiological conditions [3]. Body mass index (BMI) also affects the stimulated PGH level [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Relationship between the Stimulated Peak Growth Hormone Level and Metabolic Parameters in Children with Growth Hormone Deficiency

Lee¹

2023

Ewha Med J

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This study investigated the relationship between the stimulated peak growth hormone (PGH) level and comprehensive metabolic markers for glucose and lipid metabolism, and liver steatosis in prepubertal children with GH deficiency (GHD). Methods: Sixty-nine prepubertal children with GHD were divided into overweight/obesity (body mass index [BMI]≥85th percentile) and normal BMI groups. The associations between PGH level and metabolic parameters including homeostatic model assessment-insulin resistance (HOMA-IR), lipid profiles, AST, and ALT were evaluated. Results: The LDL cholesterol level was significantly higher in the overweight/obesity group than in the normal BMI group. PGH level was negatively associated with the BMI SD score (SDS) (r= −0.26, P=0.029) and ALT (r=−0.36, P=0.004) levels, whereas it was positively associated with the HDL-cholesterol (HDL-C) level (r=0.38, P=0.002). In multivariate analyses, PGH level was positively associated with HDL-C level (P=0.002) and negatively associated with ALT level (P=0.028) after adjusting for age, sex, BMI SDS, HOMA-IR, and TG level. Conclusion: PGH level in pre-pubertal children with GHD was positively and negatively associated with HDL-C and ALT, respectively, even if they were within normal range, regardless of BMI.

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Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study

Sodero¹,

Francesco²,

Michela³

et al. 2023

Growth Hormone & IGF Research

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Effect of body mass index on peak growth hormone level after growth hormone stimulation test in children with short stature

Abstract: Effect of body mass index on peak growth hormone level after growth hormone stimulation test in children with short stature

Cited by 4 publications

References 32 publications

Pragmatic Evaluation of Growth Hormone Stimulation Tests in Short Stature

Pragmatic Evaluation of Growth Hormone Stimulation Tests in Short Stature

Relationship between the Stimulated Peak Growth Hormone Level and Metabolic Parameters in Children with Growth Hormone Deficiency

Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study

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