Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis

Rittenberg, Vivian; Seshadri, Srividya; Sunkara, Sesh Kamal; Sobaleva, S.; Oteng‐Ntim, Eugene; El‐Toukhy, Tarek

doi:10.1016/j.rbmo.2011.06.018

Cited by 349 publications

(260 citation statements)

References 86 publications

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“…However, Bellver et al (67) reported an impaired IVF outcome without a poor embryo quality in obese women. They also similarly found that obese women who are undergoing ovarian stimulation in ART programmes require higher doses and a longer period of gonadotropin treatment (65). Obese infertile women who undergo ART face some difficulties during the treatment.…”

Section: Obesity and Assisted Conceptionmentioning

confidence: 89%

“…Hyperinsulinemia and insulin resistance have been detected in a large number of patients with PCOS with or without of obesity. However, in some studies, a reduced fecundity was reported in overweight and obese women with regular menses (65). These findings suggest that either anovulation continues despite the regular menses, or a combination of possible adverse effects of increased androgens on the endometrium and developing oocytes and adverse effects of increased levels of circulating leptin on the granulosa and theca cells give rise to infertility.…”

Section: Obesity and Infertilitymentioning

confidence: 96%

“…However, poor reproductive outcomes are encountered in ART, such as natural conception, and this is particularly related with central adiposity and PCOS. Rittenberg et al (65) found that women who are overweight or obese have a poorer outcome following in vitro fertilization (IVF) treatment than women within normal weight ranges. Metwally et al (66) demonstrated that there is an association between obesity and poor embryo quality in women below 35 years of age, and young obese women have a less chance of cryopreserved embryos and need a higher dose of gonadotropins.…”

Section: Obesity and Assisted Conceptionmentioning

confidence: 99%

“…They found that the pregnancy rates per cycle initiated was significantly lower in obese women than in normal weight women (15). Recent meta-analysis have investigated the effects of obesity on the chance of obtaining a pregnancy or a live birth following ART treatment (65,69,70). Rittenberg et al (65) analyzed 33 reports consisting of 47.967 treatment cycles, and they found that women who were overweight or obese had significantly decreased clinical pregnancy and live birth rates and significantly higher miscarriage rates than women with a normal BMI.…”

mentioning

confidence: 99%

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Impact of obesity on infertility in women

Dağ

Dilbaz

2015

J Turkish German Gynecol Assoc

201

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Review 111 IntroductionObesity, which is an important health issue, is a common problem among women of reproductive age. Obesity and overweight involves an abnormal and excessive fat accumulation that negatively affects the health of the body. According to the World Health Organization (WHO), if the body mass index (BMI) equals to or is greater than 25 kg/m 2 , it is considered overweight, whereas if the BMI equals to or is greater than 30 kg/m 2 , it is considered obesity (1). Obesity brings out many problems such as social, psychological, demographic, and health problems. It is related to increased health risks such as diabetes mellitus, hypertension, coronary heart disease, and osteoarthritis and is linked to various malignancies, particularly endometrium, breast, and colon cancers. Obesity also plays a significant role in reproductive disorders, particularly in women. It is associated with anovulation, menstrual disorders, infertility, difficulties in assisted reproduction, miscarriage, and adverse pregnancy outcomes. In obese women, gonadotropin secretion is affected because of the increased peripheral aromatization of androgens to estrogens. The insulin resistance and hyperinsulinemia in obese women leads to hyperandrogenemia. The sex hormone-binding globulin (SHBG), growth hormone (GH), and insulin-like growth factor binding proteins (IGFBP) are decreased and leptin levels are increased. Thus, the neuroregulation of the hypothalamic-pituitary-gonadal (HPG) axis deteriorates (2). These alterations may explain impaired ovulatory function and so reproductive health. Because of lower implantation and pregnancy rates, higher miscarriage rates, and increased maternal and fetal complications during pregnancy, obese women have a lower chance to give birth to a healthy newborn (3)(4)(5)(6). In this review, the effects of obesity on fertility and effective management of infertility in obese and overweight women is summarized. Epidemiology of obesityThe prevalence of obesity is increasing significantly worldwide. The International Obesity Task Force reported that 1,1 billion adults are overweight. They also reported that 312 million of them are obese (7). Approximately 3,4 million adults die each year because of health problems associated with obesity and being overweight. Of these, 44% of the problems are related to diabetes, 23% to ischemic heart disease, and between 7% and 41% to some malignancies associated with overweight and obesity (7). The prevelence of obesity has increased in developed countries because of a change in lifestyle, including reduced physical activity, changes in nutrition style, and an increased calorie intake (8). However, some other factors such as endocrine disorders, hormonal disorders, psychological disorders, and use of some drugs such as steroids and antidepressants may lead to obesity (9). The World Health Organization reported that 60% of women are overweight (≥25 kg/m 2 ) in the United States and most European countries and 30% of these are obese (≥30 kg/m 2 ) and 6% of these are mo...

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Section: Obesity and Assisted Conceptionmentioning

confidence: 89%

Section: Obesity and Infertilitymentioning

confidence: 96%

Section: Obesity and Assisted Conceptionmentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of obesity on infertility in women

Dağ

Dilbaz

2015

J Turkish German Gynecol Assoc

201

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“…Regarding the effect of BMI on the number of retrieved oocytes, its negative association with oocyte retrieval has already been demonstrated in literature [37,38]. Increasing the starting dose of gonadotropins is ineffective for preventing a negative ovarian response.…”

Section: Discussionmentioning

confidence: 97%

The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

Allegra

Marino

Raimondo

et al. 2016

J Assist Reprod Genet

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Purpose The objective of this study was the elucidation of the possible role of the single-nucleotide polymorphisms (SNP) at position -29 and 2039 of the FSH receptor gene (FSHR) as independent predictive markers of ovarian response. Indeed, the tailoring of reproductive treatments is crucial for both maximizing the success of IVF patients and obtaining a reduction in hypo-or hyper-response rates. Methods This prospective, observational study analyzed the association of -29 and 2039 FSHR polymorphisms with the number of retrieved oocytes in 140 patients attending an IVF/ ICSI cycle for severe male factors (≤5,000,000 spermatozoa/ mL) or tubal factors at the ANDROS Day

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