Effect of blue light emitting diode on viral hemorrhagic septicemia in olive flounder (Paralichthys olivaceus)

Ho, Diem Tho; Kim, Ahran; Kim, Nameun; Roh, Heyong Jin; Chun, Won-Kyong; Lee, Yoonhang; Kim, Do-Hyung

doi:10.1016/j.aquaculture.2020.735019

Cited by 13 publications

(7 citation statements)

References 26 publications

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“…Up to now, no published data is available on the relationship between between light spectrum and cold stress and the potential mechanisms that LDB could mitigate cold stress. However, several previous studies have indicated that there are positive effects of LDB on growth, development, immune and antioxidant responses (Villamizar et al, 2011;Shin et al, 2013;Kim et al, 2014;Sierra-Flores et al, 2016;Choi et al, 2017;Ho et al, 2020). The present study observed demonstrated that LDB alleviated oxidative stress and apoptosis induced by cold shock.…”

Section: Discussionsupporting

confidence: 51%

“…Several studies have reported effects of different colors of LEDs on growth and development in juvenile Atlantic cod and turbot (Sierra-Flores et al, 2016), European seabass larvae (Villamizar et al, 2009), and yellowtail damsel sh (Shin et al, 2013). Other researches have con rmed the interactive effects between light spectrum and other environmental factors such as starvation, bacteria or virus (Choi et al, 2012;Roh et al, 2018a;Roh et al, 2018b;Ho et al, 2020). However, to the best of knowledge, few researches investigated the relationship between light spectrum composition and cold shock in sh (Kim et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Cold Shock Induced Oxidative Stress, Apoptosis and Genome-wide Gene Expression Perturbation in the Eyes of Zebrafish and the Mitigation of Blue Wavelength Light

Peng

Han

Wen

et al. 2021

Preprint

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As global climate changes, severely temperature variations have significant impacts on survival and development of fish. While the potential effects of light wavelength on cold shock and associated mechanisms remain largely unknown in fish. Here, zebrafish were pre-exposed to white LEDs (an irradiance of 0.9 W/m2) and blue LEDs (LDB, peak at 450 nm, 0.9 W/m2) for 2 weeks, and then exposed to 26℃ or 11℃ for 48 hours, respectively. Cold shock led to low survival rate. Cold shock altered retinal structure, increased the number of apoptotic cells and Caspase-3 activity, inhibited superoxide dismutase (SOD) and catalase (CAT) activities, up-regulated mRNA expression of (NF-E2-related factor 2) nrf2, p53, casp3 and casp9, and down-regulated cat expression in fish eyes. These results demonstrated that acute cold exposure induced oxidative stress and apoptosis in zebrafish eyes, which may lead to mortality. However, cold shock in combination with LDB apparently mitigated these negative effects, which might be involved in the up-regulation of antioxidant response and down-regulation of apoptotic responses at transcriptional and translational levels. Furthermore, cold shock also caused dysregulation of genome-wide gene expression involved in circadian rhythm, phototransduction and il-17 signaling pathway, indicating that cold shock disturbed phototransduction cascade and circadian rhythm signals and caused inflammatory responses. Ten key genes involved in circadian rhythm, phototransduction, cell cycle arrest, RNA processing or inflammatory responses were identified, including muc5d, rnps1, si:dkey-243i1.1, opn1mw1, gadd45ba, cebpd, btg2, si:dkey-242g16.2, nr1d1 and zgc:122979, which may play an important role in the protection of LDB against cold shock. Finally, our study suggested the relationship between spectrum and cold stress and demonstrated LDB could protect fish against the negative effect of cold stress in the eyes.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Cold Shock Induced Oxidative Stress, Apoptosis and Genome-wide Gene Expression Perturbation in the Eyes of Zebrafish and the Mitigation of Blue Wavelength Light

Peng

Han

Wen

et al. 2021

Preprint

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“…saliva, blood, etc.) containing both endogenous and/or exogenous photosensitizers (to create the ROS required for inactivation), 405nm light was shown to inactivate viruses such as feline calcivirus (FCV) 30 , viral hemorrhagic septicemia virus (VHSV) 31 and murine norovirus-1 32 using unsafe, commercially impractical irradiance levels. This highlights the importance of answering the basic scientific questions related to viral inactivation within the context of the applied science required for clinical application.…”

Section: Introductionmentioning

confidence: 99%

The virucidal effects of 405 nm visible light on SARS-CoV-2 and influenza A virus

Rathnasinghe

Jangra

Miorin

et al. 2021

Sci Rep

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The germicidal potential of specific wavelengths within the electromagnetic spectrum is an area of growing interest. While ultra-violet (UV) based technologies have shown satisfactory virucidal potential, the photo-toxicity in humans coupled with UV associated polymer degradation limit their use in occupied spaces. Alternatively, longer wavelengths with less irradiation energy such as visible light (405 nm) have largely been explored in the context of bactericidal and fungicidal applications. Such studies indicated that 405 nm mediated inactivation is caused by the absorbance of porphyrins within the organism creating reactive oxygen species which result in free radical damage to its DNA and disruption of cellular functions. The virucidal potential of visible-light based technologies has been largely unexplored and speculated to be ineffective given the lack of porphyrins in viruses. The current study demonstrated increased susceptibility of lipid-enveloped respiratory pathogens of importance such as SARS-CoV-2 (causative agent of COVID-19) and influenza A virus to 405 nm, visible light in the absence of exogenous photosensitizers thereby indicating a potential alternative porphyrin-independent mechanism of visible light mediated viral inactivation. These results were obtained using less than expected irradiance levels which are considered safe for humans and commercially achievable. Our results support further exploration of the use of visible light technology for the application of continuous decontamination in occupied areas within hospitals and/or infectious disease laboratories, specifically for the inactivation of respiratory pathogens such as SARS-CoV-2 and Influenza A.

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“…Given the lack of endogenous photosensitizers such as porphyrins in virions, efficient decontamination of viruses (both enveloped and non-enveloped) may require the addition of exogenous photosensitizers 23 . With the use of media suspensions containing both endogenous and/or exogenous photosensitizers, inactivation of viruses such as feline calcivirus (FCV) 30 , viral hemorrhagic septicemia virus (VHSV) 31 and murine norovirus-1 32 has demonstrated the virucidal potency of 405 nm visible light using porphyrin rich media such as saliva, blood, etc. (to create the ROS required for inactivation) using unsafe, commercially impractical irradiance levels.…”

Section: Introductionmentioning

confidence: 99%

The virucidal effects of 405 nm visible light on SARS-CoV-2 and influenza A virus

Rathnasinghe

Jangra

Miorin

et al. 2021

Preprint

View full text Add to dashboard Cite

Germicidal potential of specific wavelengths within the electromagnetic spectrum is an area of growing interest. While ultra-violet (UV) based technologies have shown satisfactory virucidal potential, the photo-toxicity in humans coupled with UV associated polymer degradation limit its use in occupied spaces. Alternatively, longer wavelengths with less irradiation energy such as visible light (405 nm) have largely been explored in the context of bactericidal and fungicidal applications. Such studies indicated that 405 nm mediated inactivation is caused by the absorbance of porphyrins within the organism creating reactive oxygen species which result in free radical damage to its DNA and disruption of cellular functions. The virucidal potential of visible-light based technologies has been largely unexplored and speculated to be not effective given the lack of porphyrins in viruses. The current study demonstrated increased susceptibility of lipid-enveloped respiratory pathogens of importance such as SARS-CoV-2 (causative agent of COVID-19) as well as the influenza A virus to 405nm, visible light in the absence of exogenous photosensitizers, indicating a potential porphyrin-independent alternative mechanism of visible light mediated viral inactivation. Given that visible light is generally safe to humans, our results support further exploration of the use of visible light technology for the application of continuous decontamination in areas within hospitals and/or infectious disease laboratories, specifically for the inactivation of respiratory pathogens such as SARS-CoV-2 and Influenza A.

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Effect of blue light emitting diode on viral hemorrhagic septicemia in olive flounder (Paralichthys olivaceus)

Cited by 13 publications

References 26 publications

Cold Shock Induced Oxidative Stress, Apoptosis and Genome-wide Gene Expression Perturbation in the Eyes of Zebrafish and the Mitigation of Blue Wavelength Light

Cold Shock Induced Oxidative Stress, Apoptosis and Genome-wide Gene Expression Perturbation in the Eyes of Zebrafish and the Mitigation of Blue Wavelength Light

The virucidal effects of 405 nm visible light on SARS-CoV-2 and influenza A virus

The virucidal effects of 405 nm visible light on SARS-CoV-2 and influenza A virus

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