Effect of Blood Transfusions on Immune Function

Waymack, J. P.; Gallon, Lois S.; Barcelli, Uno; Trocki, O.; Alexander, J. Wesley

doi:10.1001/archsurg.1987.01400130062009

Cited by 111 publications

(21 citation statements)

References 16 publications

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“…In animals, syngeneic transfusions have not been shown to have the adverse effects on malignant disease seen with allogeneic transfusion. 22,23 The results of our study suggest that perioperative autologous blood transfusion is not associated with increased recurrence rates.…”

Section: Commentmentioning

confidence: 58%

Autologous and Heterologous Blood Transfusion in Head and Neck Cancer Surgery

Moir¹,

Samy²,

Hanasono³

et al. 1999

Arch Otolaryngol Head Neck Surg

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Objective: To determine if the use of autologous blood ameliorates the increased risk for cancer recurrence that has been associated with perioperative blood transfusion.Design: Retrospective medical record review.Setting: Tertiary care hospital.Patients: One hundred sixty-five consecutive patients with stages II to IV squamous cell carcinoma of the head and neck treated surgically at a university hospital from January 1, 1989, through December 31, 1994. Main Outcome Measures:We evaluated the impact of perioperative autologous and heterologous blood transfusion and 10 other variables on recurrence. Univariate and multivariate analyses were used.Results: Heterologous blood recipients had a 59% recurrence rate, whereas those who had received autologous blood or no transfusion had recurrence rates of 33% and 35%, respectively. The following 4 variables had a statistically significant association with recurrence by multivariate analysis: previous treatment of current malignancy (PϽ.001); receipt of heterologous blood (P = .04); positive margin (P = .04); and nodal disease (P = .04). The receipt of heterologous blood was associated with a 40% increased risk for recurrence.

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Section: Commentmentioning

confidence: 58%

Autologous and Heterologous Blood Transfusion in Head and Neck Cancer Surgery

Moir¹,

Samy²,

Hanasono³

et al. 1999

Arch Otolaryngol Head Neck Surg

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“…In contrast to this, Francis [13]and Kalechmann et al [24]reported dose–related increases in PGE 2 concentrations 7 days after blood transfusion. Waymack et al [25]and Lenhard et al [26]observed a twofold increase in PGE 2 after transfusion in animals. Elevated plasma concentrations of PGE 2 of >10 –6 M , as reported by Kinsella et al [27], which had a suppressive effect on lymphocytes and macrophages, were not observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Eicosanoids after Transfusion of Intraoperatively Salvaged Blood

et al. 2000

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Background: The interest in autologous red blood cell salvage is increasing rapidly, but it is well known that platelets and white cells are activated during cell washing. Therefore, we aimed to determine whether or not eicosanoids transfused together with the salvaged blood are responsible for nonhemolytic immunological transfusion reactions. Materials and Methods: In 11 patients who underwent radical prostatectomy we studied the release of eicosanoids, prostaglandin E₂ (PGE₂) and thromboxane B₂ (TxB₂), in association with reinfusion of intraoperatively salvaged blood. Blood samples were taken before operation, on days 1 and 3 after operation and before and after cell washing. Results: There was a twofold increase in PGE₂ and a twentyfold increase in TxB₂ in the unwashed salvaged blood. Washing caused a reduction in eicosanoid plasma levels of up to 95%, but a significantly lower level in relation to its corresponding preoperative value was only found for PGE₂. After transfusion of an average of 420 ml RBC sediment from washed blood, the patients’ plasma concentrations of PGE₂ and TxB₂ on the 1st and 3rd postoperative day did not significantly differ compared to baseline values. Conclusion: Our data support the notion that RBC sediment from ‘salvaged’ and washed autologous blood contains increased amounts of PGE₂ and TxB₂. It remains, however, questionable if these passively infused eicosanoids become biologically active. According to our study, the PGE₂ and TxB₂ transfused are apparently not responsible for nonhemolytic immunological transfusion reactions.

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“…Some of these patients show a response against the tumor on reduction or cessation of the immunosuppressive therapy [89]. -Animal studies show an increase in tumor growth following allogeneic blood transfusions [90,91]. However, the following points may explain the lack of proof from the clinical studies: -Not all blood transfusions result in immunosuppression and prolonged graft survival.…”

Section: Cancer Recurrencementioning

confidence: 99%

Blood Transfusion as Regulator of the Immune Response

Watering¹

2006

Transfus Med Hemother

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Immunologically mediated transfusion reactions have always been an important part of transfusion medicine. An additional use for blood transfusions has been investigated for several years now. Blood transfusions were previously predominantly regarded as a ‘substrate’ for immunologically mediated transfusion reactions, like in hemolytic transfusion reactions, or as a substrate for future immunologically mediated transfusion reactions, like in alloimmunization. Following the reports on the ‘blood transfusion effect’ on allograft survival, a new role for blood transfusions as immunomodulator or immunosuppressor has been discovered. Different aspects of the immunoregulatory effects of blood transfusions will be discussed.

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Effect of Blood Transfusions on Immune Function

Cited by 111 publications

References 16 publications

Autologous and Heterologous Blood Transfusion in Head and Neck Cancer Surgery

Autologous and Heterologous Blood Transfusion in Head and Neck Cancer Surgery

Plasma Levels of Eicosanoids after Transfusion of Intraoperatively Salvaged Blood

Blood Transfusion as Regulator of the Immune Response

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