Effect of blood pressure on diabetic nephropathy

Abstract

Background: Hypertension is known to be risk factor for the development of proteinuria in patients with uncontrolled diabetes mellitus type2, leads to progression of end stage renal disease Aims & Objective: To study the effect of hypertension on diabetic nephropathy in type 2 diabetic patients. Material and Methods: We investigated, progression of diabetic nephropathy by measuring arterial blood pressure , serum creatinine and glomerular filtration rate(GFR) level in 60 (35 men and 25 women) type 2 uncontrolled diabetes mellitus patients on antihypertensive treatment. Results: The survey was done for 6 months during which 30 (group 1)-uncontrolled diabetes mellitus patients with normal blood pressure were compared with 30 (group 2)-Uncontrolled diabetes mellitus patients with hypertension who had mean systolic blood pressure (SBP) was 148.86 ± 5.12 mmHg. In group 2 the mean level of serum creatinine (1.71 ± 0.46 mg/dl) was significantly higher and mean GFR (54.57 ± 35.26 ml/min) was significantly lower than group 1 (P < 0.05). Conclusion: Uncontrolled hypertension leads to progression of diabetic nephropathy with decline in GFR earlier than normotensive uncontrolled diabetic patients.