Effect of blood flow restriction combined with low-intensity training on the lower limbs muscle strength and function in older adults: A meta-analysis

Zhang, Tianqi; Wang, Xing; Wang, Jing

doi:10.1016/j.exger.2022.111827

Cited by 13 publications

(18 citation statements)

References 44 publications

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“…The current study found that the intervention effect of LIRT + BFR on lower limb muscle strength was better than that of daily exercise and LIRT, but in comparison, the effect of HIRT was better than that of LIRT + BFR, which was generally consistent with the previous results [ 15 ]. HIRT promoted muscle strength increase mainly through high load stimulation to collect higher levels of high threshold motor unit involvement [ 36 ], which has been found that EMG amplitude was greater after HIRT than that after LIRT + BFR [ 37 , 38 ].…”

Section: Discussionsupporting

confidence: 91%

“…It has been demonstrated that LIRT + BFR induces fast-twitch muscle fiber to participate in muscle work to maintain muscle strength, increases the secretion of growth hormone and activates the mechanism of muscle growth, effectively increasing muscle strength and mass in middle-aged and older adults [ 12 , 13 , 14 ]. The increase in muscle mass and strength could improve muscle function [ 15 ]. Moreover, LIRT + BFR stimulates angiogenesis and enhances endothelial function, which in turn improves muscle function [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Low Intensity Resistance Training with Blood Flow Restriction on Fall Resistance in Middle-Aged and Older Adults: A Meta-Analysis

Wang

Xin

et al. 2023

IJERPH

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Objective: To systematically evaluate the effect of low intensity resistance training with blood flow restriction on fall resistance in middle-aged and older adults. Methods: PubMed, The Cochrane Library, Web of Science, Embase, EBSCO host, CNKI Database, VIP, Wanfang Database and CBMdisc were searched, and the retrieval period was from the beginning of each database to 25 July 2022. Randomized controlled trials were collected concerning the intervention of low intensity resistance training with blood flow restriction on lower limb muscle strength, muscle mass, muscle function, balance, walking and other fall resistance indicators in middle-aged and older adults. Cochrane Risk of Bias Tool was used for methodological quality assessment of the included literature. Statistical analysis was performed using RevMan 5.4 software and Stata 15.1. Results: A total of 14 randomized controlled trials (419 participants in total) were included in the study. Meta-analysis results revealed that low intensity resistance training with blood flow restriction significantly improved lower limb muscle strength (SMD = 0.51, 95%CI: [0.28, 0.74], p < 0.0001), lower limb muscle mass (MD = 1.99, 95%CI: [0.77, 3.22], p = 0.001) and walking ability (SMD = −0.89, 95% CI. [−1.71, −0.06], p = 0.03), while there was no apparent intervention effect on lower limb muscle function (SMD = 0.25, 95%CI: [−0.23, 0.73], p = 0.31) and balance (SMD = 0.22, 95%CI: [−0.08, 0.52], p = 0.15). The results of subgroup analysis showed that the intervention effect of low intensity resistance training with blood flow restriction on lower limb muscle strength was more significant in subjects aged 55–64 years, with exercise cycles of 4–8 weeks, exercise frequency of three times per week, exercise intensity of 20–30% 1RM, and vascular flow blocking pressure ≥ 120 mmHg. Conclusion: Low intensity resistance training with blood flow restriction can effectively improve lower limb muscle strength, muscle mass and walking ability in middle-aged and older adults, and can serve as an important form of fall resistance training for the older adults.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The Effect of Low Intensity Resistance Training with Blood Flow Restriction on Fall Resistance in Middle-Aged and Older Adults: A Meta-Analysis

Wang

Xin

et al. 2023

IJERPH

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“…Evidence suggests that strength training is useful in the treatment of many of the clinical complaints of this type of subject [ 52 , 53 ]. In the meta-analysis conducted by Cruickshank et al about strength training, it was found that it was beneficial for fatigue, functional capacity and quality of life in multiple sclerosis [ 54 ].This is consistent with the articles in our review that studied BFR in this pathology, although it should be noted that it was accompanied by aerobic exercise rather than strength training [ 34 , 55 ].Other authors who studied the effect of BFR with strength training [ 19 ] found that BRF with low-load strength training is well tolerated by people with MS, requiring less muscular effort and causing no pain, compared to high-load training.…”

Section: Discussionsupporting

confidence: 91%

Effectiveness of Blood Flow Restriction in Neurological Disorders: A Systematic Review

et al. 2022

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There is scientific evidence that Blood Flow Restriction (BFR) is beneficial in healthy people, the elderly and patients with musculoskeletal disorders. A systematic review was conducted to evaluate the effectiveness of BFR in patients with neurological disorders. The literature search was conducted up until July 2022 in the following databases: PubMed, Web of Science (WOS), Physiotherapy Evidence Database (PEDro), LILACS, Scopus, Cumulative Index of Nursing and Allied Literature Complete (CINAHL), the Cochrane Library and Scientific Electronic Library Online (SciELO). The PEDro scale was used to analyze the methodological quality of the studies, and the Cochrane Collaboration’s tool was employed to evaluate the risk of bias. A total of seven articles were included. BFR seems to be beneficial in neurological disorders. Improvements have been found in sensorimotor function, frequency and step length symmetry, perceived exertion, heart rate and gait speed, walking endurance, fatigue, quality of life, muscles thickness, gluteus density and muscle edema. No improvements were found in lower limb strength or balance. However, results must be taken with caution due to the small number of articles and to the large heterogeneity. More clinical trials are needed. These studies should homogenize the protocols used in larger samples, as well as improve their methodological quality.

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“…Furthermore, certain recent meta-analyses have also concluded that BFRt tends to result in less muscle strength gain than HIRT in older adults [ 23 , 24 ]. In contrast, the results of other meta-analyses showed that BFRt produced the same muscle strength gain as HIRT in older adults.…”

Section: Introductionmentioning

confidence: 99%

“…This meta-analysis indicated that training duration may be the key variable that positively correlates with muscle strength gain in older adults. However, the included trials in this meta-analysis comprised multiple forms of exercise combined with BFR, and findings that emphasize the benefits of BFR specifically combined with LIRT are limited [ 23 ]. In addition, the influence of training frequency combined with BFR on muscle strength/mass has not been addressed in middle-aged adults.…”

Section: Introductionmentioning

confidence: 99%

Effects of Blood Flow Restriction Combined with Low-Intensity Resistance Training on Lower-Limb Muscle Strength and Mass in Post-Middle-Aged Adults: A Systematic Review and Meta-Analysis

Chang

Yao

Chen

et al. 2022

IJERPH

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We studied the effect of blood flow restriction (BFR) combined with low-intensity resistance training (LIRT) on lower-limb muscle strength and mass in post-middle-aged adults. The PubMed, OVID, ProQuest, Cochrane Library, EMBASE, Web of Science, and Scopus databases were used to obtain randomized controlled trials, and the effects of BFR and LIRT (BFRt) on muscle strength and mass in adults were examined. The Cochrane risk of bias tool assessed bias in the included trials. The combined effects of BFR and LIRT (BFRt) were calculated by meta-analysis, the association between muscle strength/mass and interventions was determined by meta-regression, and beneficial variables of intervention were explored by subgroup analysis. A total of 11 articles were included in the meta-analysis. The combined effects showed that BFRt significantly improved lower extremity muscle strength but not muscle mass gain. Meta-regression analysis indicated that the effect of BFRt on changes in muscle strength was correlated with frequency of the intervention. Subgroup analysis revealed that BFRt achieved greater muscle strength gains than normal activity, LIRT, and similar muscle strength gains compared to high-intensity resistance training. The increased muscle strength after BFRt was noticed with a frequency of three times a week, but not with a frequency of two times a week, and the difference between these subgroups was statistically significant. Our findings indicate that BFRt can increase lower-limb muscle strength in post-middle-aged adults. Frequency of intervention is a key variable; particularly, a schedule of three times a week is effective in improving muscle strength.

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Effect of blood flow restriction combined with low-intensity training on the lower limbs muscle strength and function in older adults: A meta-analysis

Cited by 13 publications

References 44 publications

The Effect of Low Intensity Resistance Training with Blood Flow Restriction on Fall Resistance in Middle-Aged and Older Adults: A Meta-Analysis

The Effect of Low Intensity Resistance Training with Blood Flow Restriction on Fall Resistance in Middle-Aged and Older Adults: A Meta-Analysis

Effectiveness of Blood Flow Restriction in Neurological Disorders: A Systematic Review

Effects of Blood Flow Restriction Combined with Low-Intensity Resistance Training on Lower-Limb Muscle Strength and Mass in Post-Middle-Aged Adults: A Systematic Review and Meta-Analysis

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