Effect of Blockade of Tumor Necrosis Factor-α with Etanercept on Surgical Wound Healing in SWISS-OF1 Mice

Abstract

Surgical wounds showed a higher degree of collagenization at 20 days in etanercept-treated versus untreated mice, with no differences in the time course of wound healing. These data suggest that biological therapies to block TNF-alpha do not affect wound healing and do not need to be suspended during the perioperative period.

Infliximab’s influence on anastomotic strength and degree of inflammation in intestinal surgery in a rabbit model

“…As in our study, they found that the inflammatory cell counts in the wound area were higher in the non-treated animals although this was not statistically significant. They concluded that biological therapies, that inhibit the effect of the TNF-α molecule, does not affect wound healing and does not need to be suspended preoperatively [30]. …”

Évaluation du rapport bénéfice-risque de la suspension des anti-TNF alpha en chirurgie orale

“…En effet, le TNF alpha est essentiel au bon déroulement de la cicatrisation. Dans une étude chez la souris sous ETN, Iglesias et al ont conclu à une durée de cicatrisation similaire avec ou sans anti-TNF [44]. Plusieurs études rétrospectives [11][12][13][14] ainsi que l'étude prospective de Bibbo et al [9] n'ont pas conclu à davantage de complications chez les patients sous anti-TNF.…”

Perioperative Management of Non-Biological and Biological Therapies in Rheumatic Patients Undergoing Orthopedic Surgery

“…Experimental results of TNF-a administration in murine models of wound-healing complications have not been consistent. Although TNF-a inhibition could theoretically have a negative impact on wound-healing (13), studies by our group and other authors suggest that it may improve collagenization of the wound (14), supporting its continuation during the perioperative period (Fig 3 and 4). No data are available on the effect of rituximab on surgical complications in RA patients.…”