Effect of Blepharis maderaspatensis L. Roth. extracts on serum lipids in Triton WR-1339 and high cholesterol diet induced hyperlipidemia in rats

Rajasekaran, A.; Sivakumar, Vellaichamy; Darlinquine, Sabarimuthu

doi:10.5897/ajpp11.468

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…Thus, the P. curatellifolia seed could protect against possible cardiovascular disease risks associated with dyslipidemia, thereby highlighting its potential therapeutic use in the management of abnormalities in lipid metabolism. Atherogenic risk predictor indices were suggested for use in the clinical setting to assess the risk of cardiovascular disease beyond routine lipid profile assessment . The positive relationship between LDL‐c, CRI and ARI was clearly observed in the present study (Fig.…”

Section: Discussionsupporting

confidence: 59%

“…Plasma lipid profiles (TC, TG, LDL‐c, and HDL cholesterol (HDL‐c)) were estimated using assay kits supplied by Randox Laboratories, following the manufacturer's instructions. LDL‐c/HDL‐c ratio was determined and atherogenic risk index (ARI) and coronary risk index (CRI) were calculated as follows: ARI = (TC–HDL‐c)/HDL‐c and CRI = TC (mg/dL)/HDL‐c .…”

Section: Methodsmentioning

confidence: 99%

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Parinari curatellifolia seed flavonoids protect against Triton‐induced dyslipidemia and atherogenicity in rats

Crown

Komolafe

Akinmoladun

et al. 2017

Traditional & Kampo Medicine

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Aim: Parinari curatellifolia seed flavonoid extract (PFE) and crude methanol extract (PME) were investigated for their effects on Triton X-100 (TRT; 200 mg/kg i.p.)-induced dyslipidemia in rats. Methods: Experimentally induced hyperlipidemic and un-induced, normal rats were treated with nicotinic acid (300 mg/kg), PFE (20, 25, 30 mg/kg) or PME (100, 150 mg/kg) once daily by gavage for 10 days, following which the biochemistry and histology of the heart, aorta and sera were analyzed. Results: The seed extracts produced slight decreases in serum activities of the cardiac markers creatine kinase and lactate dehydrogenase, and did not perturb the cardiac antioxidant status of normal rats. TRT promoted cardiac oxidative stress, decreased high-density lipoprotein cholesterol (75%, P < 0.001) and increased total cholesterol (TC; 97%, P < 0.001), triglycerides (138%, P < 0.001), low-density lipoprotein cholesterol (LDL-c; 281%, P < 0.001), coronary risk index (CRI; sixfold) and atherogenic risk index (ARI; 13-fold). PFE (20 mg/kg) and PME (150 mg/kg), respectively, restored cardiac antioxidant status and significantly ameliorated the astronomical changes produced by TRT as regards TC (56% and 31%), triglycerides (70% and 66%), LDL-c (96% and 46%), CRI (92% and 78%) and ARI (99% and 83%), with relatively better efficacy than the reference compound, nicotinic acid (P < 0.01/0.001). In addition, improved heart and aortic histological architecture was observed in rats treated with both extracts. On high-performance liquid chromatography screening, kaempferol, rutin, and quercitrin were identified as some of the active phytochemicals in PFE. Conclusion: P. curatellifolia seed flavonoids have remarkable anti-hyperlipidemic and anti-atherogenic effects in acute dyslipidemia caused by TRT.

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Section: Discussionsupporting

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Parinari curatellifolia seed flavonoids protect against Triton‐induced dyslipidemia and atherogenicity in rats

Crown

Komolafe

Akinmoladun

et al. 2017

Traditional & Kampo Medicine

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“…18 Stress oxidative was sign by MDA level, so MDA level used by the biology mark or measure of oxidative stress in the body. 19 It appropriate with the increased of infiltration lipid in the aorta which shows oxidative damage in lipid (LDL oxidation to LDLox). 20 The aorta histopathology or rat (Rattus norvegicus) on figure 1.A (negative group) showed normal conditions in tunica intima.…”

Section: Resultsmentioning

confidence: 99%

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

et al. 2020

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Green grass jelly (Premna oblongifolia merr) is a plant containing fiber and chlorophyll which can lower cholesterol and triglyceride levels. This study have aims to investigate the potency of green grass jelly extract (Premna oblongifolia Merr) to prevent hyperlipidemia. The animal mode used for this study is male Rattus norvegicus, Wistar strain, the age of 8 weeks, and weight of 200 g which is divided into 5 groups of treatment namely group Kn (negative control), Kp (positive control), Kp1, Kp2, and Kp3 induced with HFD and green grass jelly extract at a dose of 5.27 g/ kg BW/ daily, 8.43 g/ kg BW/ daily, 9.37 g/ kg BW/ daily. The data of infiltrating fatty cells and macrophage on aorta histopathology was analyzed by description. This research showed that the treatment of green grass jelly extract (Premna oblongifolia Merr) to animals of hyperlipidemia model reduced infiltration fatty cells and macrophage. The conclusion of this study was the green grass jelly extract was able to prevent an increase of fatty cells and macrophage infiltration of rat (Rattus noervegicus) induced with HFD on dose 9.37 g/ kg/ BW/ daily.

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“…It is well known that diet plays an important role in the control of cholesterol homeostasis. The consumption of cholesterol-enriched diet is regarded as an important factor in the development of cardiovascular diseases as it leads to the development of hyperlipidemia, atherosclerosis and abnormal lipid oxidation/metabolism [29,30]. The hypolipidemic activity of the groups taken extracts or powder fractions of D. mespiliformis was found to be slightly less efficacious than that of the standard drug but compared to the negative control group, their total cholesterol, triglyceride, LDL-C and VLDL-C are significantly low and their HDL-c higher.…”

mentioning

confidence: 99%

Antihyperlipidemic Properties of Powder Fractions and Extracts of Diospyros Mespiliformis HOCHST Fruits

Chantal¹,

Josiane²,

Nicolas³

2019

SARJBAB

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Hyperlipidemia is one of the major risk factors for the development of cardiovascular disease. Many bioactive compounds extracted from plants, particularly polyphenols, have demonstrated a beneficial effect on health. Obtaining these molecules requires extraction, conventional extraction techniques uses solvents whose residue affects these compounds, the environment and the health of consumers. Faced with these problems some techniques, a new axis has been developed it is the dry extraction (controlled sieving-differential spray). Diospyros mesiliformis is poorly studied regarding the bioactive compounds of its fruits. The aim of this study is to find out the optimal conditions for the dry extraction of bioactive compounds compare to solvent extraction and to study antihyperlipidemic activity of the fruit. Granulometric classes ranging from 50 μm to 315 μm were studied. Hydroethanolic and ethanolic extracts of Diospiros mesiliformis were analyzed for total phenolic, total flavonoid, and total tannin contents. For study of antihyperlipidemiac activity, hyperlipidemia was induced by feeding animals with high fat diet daily and orally ad libitum. Ten groups of five animals in each received normal saline, high fat diet, high fat diet plus D. mesiliformis powder (600 mg/kg) and extracts (600 mg/kg) body weight was given in both models and Atorvastatin (10mg/kg) body weight was given in both models respectively for 30 days. At the end of the study, total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein (LDL), atherogenic index (AI) of rats were evaluated and were compared with the rats treated with Atorvastatin (10mg/kg) body weight. The particle size and the extracts had high influence on the total phenolic compounds, total flavonoid and tannin content as well as on the antihyperlipidemic activity. Diospyros mespiliformis can be safely used in the treatment of mild to moderate cases of hyperlipidemia considering its easy availability, cost effectiveness, and other beneficial effects.

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Effect of Blepharis maderaspatensis L. Roth. extracts on serum lipids in Triton WR-1339 and high cholesterol diet induced hyperlipidemia in rats

Cited by 10 publications

References 26 publications

Parinari curatellifolia seed flavonoids protect against Triton‐induced dyslipidemia and atherogenicity in rats

Parinari curatellifolia seed flavonoids protect against Triton‐induced dyslipidemia and atherogenicity in rats

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

Antihyperlipidemic Properties of Powder Fractions and Extracts of Diospyros Mespiliformis HOCHST Fruits

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