Effect of blending ratio on morphological, chemical, and thermal characteristics of PLA/PCL and PLLA/PCL electrospun fibrous webs

Oztemur, Janset; Ozdemir, Suzan; Yalcin-Enis, Ipek

doi:10.1080/00914037.2022.2090356

Cited by 5 publications

(7 citation statements)

References 59 publications

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“…For the process of manufacturing the tubular scaffolds with randomly distributed and radially oriented fibers, PCL, PLA, and PLCL polymers are all dissolved in CHL/ETH/AA (8/1/1 wt) which has been optimized in preliminary studies. ,,, PCL and PLA solutions are prepared in neat or blended forms, whereas PLCL is used in the neat form. By varying the blending ratio (90/10, 80/20, 70/30, 60/40, and 50/50) by increasing 10 in the range of 50–100%, optimum blend ratios that will eliminate the individual deficiencies of each polymer are determined. , The polymer concentration for the solutions made of both pure PCL and PLA and their blends is determined as 8% wt. , while PLCL solution is prepared at 10% wt .…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…By varying the blending ratio (90/10, 80/20, 70/30, 60/40, and 50/50) by increasing 10 in the range of 50−100%, optimum blend ratios that will eliminate the individual deficiencies of each polymer are determined. 14,23 The polymer concentration for the solutions made of both pure PCL and PLA and their blends is determined as 8% wt. 14,21 while PLCL solution is prepared at 10% wt.…”

Section: ■ Introductionmentioning

confidence: 99%

“…14,23 The polymer concentration for the solutions made of both pure PCL and PLA and their blends is determined as 8% wt. 14,21 while PLCL solution is prepared at 10% wt. 19 The tubular scaffolds made of PCL, PLA, and PLCL polymers are manufactured by using a custom-made electrospinning unit with a vertical feeding direction and closed chamber supplied from Inovenso, Turkey (Nanospinner, Ne100+).…”

Section: ■ Introductionmentioning

confidence: 99%

“…Researchers have recently been highly interested in synthetic biomaterials such as PCL and PLA and their copolymers to eliminate the mechanical inadequacies of natural biopolymers . PCL is one of the most promising and commonly preferred material options for vascular graft fabrication since it is a highly biocompatible polymer with a long biodegradation period and sufficient flexibility . Contrarily, PLA is a strong and brittle aliphatic polyester with a biodegradation rate that can be altered depending on its usage area, making its use in biomedical fields easier and more effective, especially if it is used with ductile polymers. , In literature, the blending or copolymerization of PCL and PLA with each other is known to be promising in terms of biological and mechanical activities .…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Electrospun Bilayer Vascular Grafts through Assessment of the Mechanical Properties of Monolayers

Ozdemir,

Oztemur,

Sezgin

et al. 2024

ACS Biomater. Sci. Eng.

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Small-diameter vascular grafts must be obtained with the most appropriate materials and design selection to harmoniously display a variety of features, including adequate tensile strength, compliance, burst strength, biocompatibility, and biodegradability against challenging physiological and hemodynamic conditions. In this study, monolayer vascular grafts with randomly distributed or radially oriented fibers are produced using neat, blended, and copolymer forms of polycaprolactone (PCL) and poly(lactic acid) (PLA) via the electrospinning technique. The blending ratio is varied by increasing 10 in the range of 50−100%. Bilayer graft designs are realized by determining the layers with a random fiber distribution for the inner layer and radial fiber orientation for the outer layer. SEM analysis, wall thickness and fiber diameter measurements, tensile strength, elongation, burst strength, and compliance tests are done for both mono-and bilayer scaffolds. The findings revealed that the scaffolds made of neat PCL show more flexibility than the neat PLA samples, which possess higher tensile strength values than neat PCL scaffolds. Also, in blended samples, the tensile strength values do not show a significant improvement, whereas the elongation values are enhanced in tubular samples, depending on the blending ratio. Also, neat poly(L-lactide-co-caprolactone) (PLCL) samples have both higher elongation and strength values than neat and blended scaffolds, with some exceptions. The blended specimens comprising a combination of PCL and PLA, with blending ratios of 80/20 and 70/30, exhibited the most elevated burst pressures. Conversely, the PLCL scaffolds demonstrated superior compliance levels. These findings suggest that the blending approach and fiber orientation offer enhanced burst strength, while copolymer utilization in PLCL scaffolds without fiber alignment enhances their compliance properties. Thus, it is evident that using a copolymer instead of blending PCL and PLA and combining the PLCL layer with PCL and PLA monolayers in bilayer vascular graft design is promising in terms of mechanical and biological properties.

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