“…The factors affecting profitability include cultural practices, cultivar resistance, other pest damage, key fungicide-related aspects (application timing and costs, effectiveness in controlling the diseases, type of fungicides), and the price of wheat (Ordish and Dufour, 1969;Carlson and Main, 1976). Plant physiological responses to fungicide exposure may also impact the profitability (Nason et al, 2007;Berdugo et al, 2012;Dias, 2012). Furthermore, fungicides might affect naturally occurring microflora (especially yeasts) on the phylloplane which might provide protection against pathogens, thus increasing the susceptibility of the plant to the pathogens (Bashi and Fokkema, 1977;Magan and Lacey, 1986;Mukerji et al, 1999;Rodgers-Gray and Shaw, 2001;Wachowska, 2005).…”