Effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats

Vijayalakshmi, B.; Kumar, G. Suresh; Salimath, Paramahans V.

doi:10.1016/j.jdiacomp.2007.09.005

Cited by 16 publications

(9 citation statements)

References 41 publications

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“…Vijayalakshmi et al. (2009) suggested that bitter gourd had potential oral hypoglycemic effect and could be used as the functional food because of its antidiabetic effect. The possible mechanisms of bitter gourd which related to the antidiabetic effects had been identified including the stimulation of peripheral and skeletal muscle glucose utilization (Akhtar et al.…”

Section: Discussionmentioning

confidence: 99%

“…Bitter gourd in this study did not perform well in αglycosidase inhibitory assay, but its aldose reductase inhibitory activity, as well as the total flavonoids content was ranked at the fourth among 20 selected samples. Vijayalakshmi et al (2009) suggested that bitter gourd had potential oral hypoglycemic effect and could be used as the functional food because of its antidiabetic effect. The possible mechanisms of bitter gourd which related to the antidiabetic effects had been identified including the stimulation of peripheral and skeletal muscle glucose utilization (Akhtar et al 2011) and inhibition of glucose uptake (Uebanso et al 2007).…”

Section: Aldose Reductase Inhibitory Activities Of Selected Fruits Anmentioning

confidence: 99%

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In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase

Luo

2015

Food Science & Nutrition

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In vitro antidiabetic effect of fruits and vegetables with reports as folk remedies were investigated. The antidiabetic effects were evaluated by comparing the inhibitory properties of α‐glycosidase, aldose reductase, and antioxidant activity. The results indicated that lychee extract exhibited the best dose‐dependent inhibitory activity against α‐glycosidase with IC 50 of 10.4 mg/mL, and lemon peel extract exhibited aldose reductase inhibitory potential with IC 50 value at 3.63 mg/mL. Besides, the result also showed that the inhibitory effects of blueberry and plum against α‐glycosidase were strong among the fruits samples. Bitter gourd and eggplant demonstrated significant inhibitory potential against aldose reductase, with IC 50 values at 8.55 mg/mL and 8.06 mg/mL, respectively. The result from correlation analysis part showed that the antioxidant activities of selected fruits and vegetables were found related to their health beneficial effects, as there was positive correlations between total flavonoids content (TFC) and aldose reductase inhibitory activity (r 2 = 0.556).

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Section: Discussionmentioning

confidence: 99%

Section: Aldose Reductase Inhibitory Activities Of Selected Fruits Anmentioning

confidence: 99%

In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase

Luo

2015

Food Science & Nutrition

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“…Studies on rats have suggested that Momordica charantia extracted from bitter gourd and bitter melon may have a glucose-lowering effect [20][21][22][23]. The glucose lowering effect of rosiglitazone may be enhanced when combined with bitter gourd.…”

Section: Discussionmentioning

confidence: 99%

Understanding and beliefs of diabetes in the UK Bangladeshi population

2009

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Findings from this study can be used to help health professionals working with Bangladeshi people. There is a need for improved information for Bangladeshi people and much of this information might need to come from health professionals. In addition, there is a need for increased awareness by health professionals of practices used by Bangladeshi people, such as eating bitter gourd (which may enhance the effects of rosiglitazone), and the influence these practices could have on the individual's diabetes management.

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“…Lectin binding is non-protein specific, and this is likely why bitter gourd has been credited with immunostimulatory activity -by linking receptors that modulate the immune system, thereby stimulating said receptors. Vijayalakshmi et al (2009) studied the changes in glycolconjugate metabolism during the development of diabetic complications and their modulation by feeding bitter gourd and spent turmeric as a fiber-rich source [48]. Treatment resulted in decreased level of total sugar content in liver, spleen, and brain while an increase in amount was observed in heart and lungs.…”

Section: Anti-diabetic Propertiesmentioning

confidence: 99%

Nutritional, Pharmacological and Medicinal Properties of Momordica Charantia

Kumar¹,

Nallamuthu²

2015

IJNFS

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Abstract:Momordica charantia L. (Bitter gourd) is a flowering vine in the family of Cucurbitaceae. It contains an array of novel and biologically active phytochemicals including triterpenes, proteins and steroids. Medicinally, the plant has a long history of use by the indigenous people as a folk medicine. Bitter gourd is often used in Chinese cooking for its bitter flavor, typically in stir-fries, soups, and also as tea. Pakistan, Philippines, Panama and Nepal also use this bitter vegetable for culinary purposes in addition to India. Several medicinal properties of the bitter gourd have been studied by various researchers, such as anti-diabetic, anti-ulcerogenic, anti-mutagenic, antioxidant, anti-tumour, anti-lipolytic, analgesic, abortifacient, anti-viral, hypoglycemic and immunomodulatory. In vitro studies reveals that the bitter gourd proteins (α-and β-monorcharin) have inhibitory effect against HIV virus, and leaf extracts have broad-spectrum anti-microbial activity as well. Many in vivo studies have demonstrated the relatively low toxicity of all parts of the bitter gourd plant when ingested orally. This review also addresses taxonomy, phytochemical, culinary practices and pharmacological properties in detail. Over the years scientists have verified many of the traditional uses of this bitter plant that continues to be an important natural remedy in herbal medicine systems. Bitter gourd products such as concentrated fruit and seed extracts can be found in capsules and tablets, as well as in whole herb/vine powder forms and these supplements are becoming more widely available in many countries nowadays as prophylactic or therapeutic agents.

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Effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats

Cited by 16 publications

References 41 publications

In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase

In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase

Understanding and beliefs of diabetes in the UK Bangladeshi population

Nutritional, Pharmacological and Medicinal Properties of Momordica Charantia

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