Effect of bisphenol A toxicity on growth performance, biochemical variables, and oxidative stress biomarkers of Nile tilapia,Oreochromis niloticus(L.)

Abstract

Bisphenol A (BPA) is one of the industrial chemical compound which is used in the production of polycarbonate plastics and epoxy resins. BPA is used throughout the world and it could enter the aquatic ecosystems causing serious problems. To evaluate the potential effects of BPA toxicity on Nile tilapia, Oreochromis niloticus (L.) performance, its lethal concentration (LC50) was determined and it was 13.13 µg/L. After that, fish (33.9 ± 0.55 g/fish) were exposed to 0.0, 1.64, or 3.28 µg/L of BPA for 6 weeks after which growth performance, biochemical variables, and oxidative defense system were assessed. The results showed that fish growth and feed intake were significantly reduced as BPA levels increased with no significant difference in fish survival. Total protein, albumin, globulin, and acetylcholine esterase decreased significantly; meanwhile, aspartate transferase, alanine transferase, alkaline phosphatase, uric acid, and creatinine increased significantly with exposure to BPA in a dose dependent manner. Furthermore, malondialdehyde value and the activities of superoxide dismutase and catalase increased significantly; while glutathione peroxidase and glutathione S‐transferase decreased significantly as BPA levels increased. In conclusion, BPA exposure in aquatic environment deteriorated fish performance and health causing liver and kidney dysfunction. Thus, fish exerted oxidative defense enzymes as a protection tool against BPA toxicity.

Ameliorative role of chitosan nanoparticles against bisphenol-A induced behavioral, biochemical changes and nephrotoxicity in the African catfish, Clarias gariepinus

“…Catfish exposed to BPA exhibited hypoproteinaemia, hypoalbuminaemia, and hypoglobulinaemia compared to the control ones. These results agreed with that documented in African catfish after pesticide exposures (Hamed, 2016;Marzouk et al, 2012;Sayed and Hamed, 2017;Abdel-Tawwab and Hamed, 2018). The depletion of serum total protein, albumin, and globulin in the BPA-exposed fish may be a result of dysfunctions of the liver and kidneys (Giron-Pérez et al, 2007).…”

“…The aquatic ecosystems are exposed to BPA through the urban sanitation, petrochemical industry discharge, and landfill leachates causing a severe problems to the aquatic organism's health (Flint et al, 2012;Rubin, 2011). Thus, its detrimental effects on aquatic animals have also received great concern (Buxton and Kolpin, 2005;Huang et al, 2012;Abdel-Tawwab and Hamed, 2018).…”

The Change of Metallothionein and Oxidative Response in Gills of the Oreochromis niloticus after Exposure to Copper

“…LPO is a highly destructive process that increases the rigidity and decreases the fluidity of cellular membranes [53]. It has been reported that the levels of MDA increased as a result of oxidation of lipoprotein and lipids in cell membranes during oxidative stress [47,54]. The current results showed that the level of MDA in the gills of all Cu-exposed fish were not significantly different with the control.…”

“…Our results suggest that Cu exposure might significantly increase free radicals in the first few days and lead to the production of ROS, causing oxidative stress in fish. It is likely that the increase of SOD and CAT was an adaptive response of the animal to Cu toxicity and it served to neutralize the impact of increased ROS generation [31,33,46,47]. Carvalho et al [48] revealed that SOD and CAT had prominent roles in the scavenging of free radicals to protect the organisms from oxidative stress.…”

Effect of the plastic pollutant bisphenol A on the biology of aquatic organisms: A meta‐analysis

“…To facilitate this process, we conducted a meta-analysis of existing literature to quantify the effects of BPA on aquatic organisms. A meta-analytic approach is important particularly because the effects of BPA on biological functions can be context dependent, and different taxa and biological traits show different responses when exposed to BPA (Abdel-Tawwab & Hamed, 2018;Martínez et al, 2019;Staples, Woodburn, Caspers, Hall, & Klecka, 2002;Wright-Walters, Volz, Talbott, & Davis, 2011). Given the ongoing development of policies regarding the environmental consequences of EDCs (Canesi & Fabbri, 2015;Crain et al, 2007;Flint, Markle, Thompson, & Wallace, 2012), there is an urgent need to evaluate environmental concentrations and their impact on aquatic organisms.…”