Effect of bisoprolol and atenolol on endurance exercise capacity in healthy men

Vanhees, Luc; Defoor, Johan; Schepers, Dirk; Lijnen, Paul; Peeters, Brigitte Y.M.; Lacante, P.; Fagard, Robert

doi:10.1097/00004872-200018010-00006

Cited by 46 publications

(30 citation statements)

References 29 publications

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“…In our subjects, the MLSS occurred at 66% and 67% of P max , indicating no influence of bisoprolol. Vanhees et al (2000) showed that subjects exercising at 70% of P max responded with higher values of LA, supporting their suggestion that cycling at this intensity represented work above the AT. Moreover, this comparison supports the rationale of an individual approach for testing the MLSS.…”

Section: At and Mlss Testmentioning

confidence: 52%

“…2) but this difference did not reach statistical significance. Kullmer et al (1987) have found significantly higher LA values, while others have found unchanged (Gullestad et al 1989;Hambrecht et al 1995;Hugson and Smyth 1983;Reybrouck et al 1977;Vanhees et al 2000;Wittke and Kemmler 1999) or decreased LA concentrations (Schnabel et al 1983) during submaximal or maximal exercise tests. A possible explanation for these contrasting findings could be intra-individual differences in LA concentrations that may have been influenced by differences in glycogen stores, nutritional status or daily variation in physiological performance capacity (Aunola and Rusko 1992;Hofmann et al 1994a;Yoshida 1984).…”

Section: At and Mlss Testmentioning

confidence: 96%

“…They have found both a significantly reduced (Kullmer et al 1987;Vanhees et al 2000) or unchanged (Brion et al 2000;Kendall 1981) test duration with cardioselective b-blockade.…”

Section: At and Mlss Testmentioning

confidence: 97%

“…Most studies with cardioselective b-blockers were performed with metoprolol (Franz and Lohmann 1979;Hambrecht et al 1995;Hughson and Smyth 1983;Kindermann et al 1984;Kullmer et al 1987;Schnabel et al 1983;Sklar et al 1982;Wittke and Kemmler 1999). Only two clinical trials have been performed to assess the effect of bisoprolol on exercise capacity (Brion et al 2000;Vanhees et al 2000).…”

Section: Introductionmentioning

confidence: 99%

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Effect of β1-selective adrenergic blockade on maximal blood lactate steady state in healthy men

et al. 2002

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The aim of this study was to compare the effect of taking bisoprolol (B), a highly beta(1)-selective adrenoceptor antagonist to that of a placebo (P) on maximal lactate steady state (MLSS), which reflects the transition from oxidative to partially anaerobic metabolism. Ten healthy male subjects [mean (SD) age 23 (3) years, height 181 (6) cm, body mass 76 (6) kg] randomly received oral P or B (5 mg x day(-1)) for 2 weeks using a double-blind crossover design. In the 2nd week, the subjects performed an incremental cycle ergometer test until exhaustion to determine the second blood lactate turn point (LTP(2)). At regular intervals of 24-48 h, the subjects performed 2-3 steady-state tests to determine the MLSS. During the incremental exercise, heart rate (HR) was significantly lower at rest (15 beats x min(-1)), at LTP(2) (23 beats x min(-1)) and at maximal power output (19 beats x min(-1)) when taking B compared to P. Oxygen pulse was significantly higher taking B and no significant differences were observed for any of the respiratory gas exchange measurements (RGEM) (oxygen consumption, carbon dioxide production, minute ventilation, respiratory exchange ratio), exercise intensity or blood lactate concentration (LA) at baseline, at LTP(2) and at maximal power output. During exercise at constant intensity, significant differences between B and P were found for HR [148 (12) compared to 176 (11) beats x min(-1)] and oxygen pulse [21.8 (1.9) compared to 19.2 (1.6) ml] at MLSS. No difference was found for exercise intensity [216 (18) compared to 218 (18) W], for RGEM, LA [5.3 (1.1) compared to 4.8 (1.5) mmol x l(-1)] and ratings of perceived exertion [18.1 (1.6) compared to 17.4 (1.7)] for B and P at MLSS. In both, the power output at LTP(2) was slightly higher than power output at MLSS (within an intensity step). Commonly measured cardiorespiratory and subjective variables determined during treatment with 5 mg bisoprolol can be used for testing cardiorespiratory fitness and for prescription of training intensity.

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Section: At and Mlss Testmentioning

confidence: 52%

Section: At and Mlss Testmentioning

confidence: 96%

“…They have found both a significantly reduced (Kullmer et al 1987;Vanhees et al 2000) or unchanged (Brion et al 2000;Kendall 1981) test duration with cardioselective b-blockade.…”

Section: At and Mlss Testmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Effect of β1-selective adrenergic blockade on maximal blood lactate steady state in healthy men

et al. 2002

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“…Bis zum Ausschluss potentiell gefährlicher Arrhythmien sind intensive körperliche Belastungen zu vermeiden. Bei der medikamentösen antiarrhythmischen Therapie gelten die in den jeweiligen Leitlinien festgelegten Grundsätze [8,17]; es sind jedoch die mit der jeweiligen Sportart verbundenen körperlichen und mentalen Belastungsmomente in der Beurteilung des Therapieerfolges zu berücksichtigen [19,20]. Zusätzlich muss berücksichtigt werden, dass unter den antiarrhythmischen Präparaten -Rezeptoren-Blocker in bestimmten Sportarten aufgrund der Dopingbestimmungen nicht zulässig sind.…”

Section: Introductionunclassified

Herzrhythmusst�rungen im Sport

Latsch

2004

Herz

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Cardiac arrhythmias in athletes are frequent events in medical practice and require a profound diagnostic procedure. It is necessary to differentiate between harmless alterations of cardiac rhythm and potentially dangerous arrhythmias. While the former are mostly the result of an increased vagotone as a consequence of endurance training, the latter are raising the question whether intensive physical and mental strains in competitive exercise are compatible with the cardiac arrhythmias diagnosed. Vagotone-induced alterations of cardiac arrhythmias generally disappear under exercise conditions. It is essential to include the type, intensity and duration of the athletic activities into the differential-diagnostic evaluations. However, those medical considerations frequently collide with economic interests. Sinus bradycardia is a typical example of vagotone-induced arrhythmias, which may be observed especially in highly endurance-trained athletes. Sinus bradycardias are mostly asymptomatic and rarely the cause of grave complications; therapeutic interventions are only required if clinical symptoms such as orthostatic disturbances are present. The different variants of cardiac conduction defects are-within certain limits-also frequently induced by an increased vagotone; generally, they require an intensive cardiologic diagnosis. Another frequent form of arrhythmias are ventricular extrasystoles. Their dignity may be assessed by exercise ECG. Disappearance under exercise conditions is, generally, a positive sign. Diagnosis and therapy of cardiac arrhythmias are based on the established guidelines. Additionally, regular cardiologic screenings are required in high-performance athletes of all age groups.

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Systemic Side Effects of Glaucoma Medications

Lama

2010

The Glaucoma Book

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Effect of bisoprolol and atenolol on endurance exercise capacity in healthy men

Cited by 46 publications

References 29 publications

Effect of β1-selective adrenergic blockade on maximal blood lactate steady state in healthy men

Effect of β1-selective adrenergic blockade on maximal blood lactate steady state in healthy men

Herzrhythmusst�rungen im Sport

Systemic Side Effects of Glaucoma Medications

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