Effect of Bismuth Lipophilic Nanoparticles (BisBAL NPs) on <i>Trichomonas vaginalis</i> Growth

Rodríguez-Luis, Osvelia E.; Hernandez-Delgadillo, Rene; Pineda‐Aguilar, Nayely; Vargas‐Villarreal, Javier; González-Salazar, Francisco; Garza-González, Jesús Norberto; Hernández-García, Magda Elizabeth; Chellam, Shankararaman; Cabral-Romero, Claudio

doi:10.1166/jnn.2017.13743

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, as a novel application of this NA, the bactericidal activities of Bi and Ag NPs as well as the Ag–Bi NA were analyzed. In previous works, Ag-rich alloyed NPs, such as those containing Au, Cu, or Pt, demonstrated superior bactericidal properties. − Although recent studies have also shown that Bi inhibits some parasitic and microbial growth − and that the addition of Bi could modify the final properties of other alloys, , to the best of our knowledge, the bactericidal activity of Ag–Bi NAs has not been studied yet.…”

Section: Results and Discussionmentioning

confidence: 94%

From Complex Inorganic Oxides to Ag–Bi Nanoalloy: Synthesis by Femtosecond Laser Irradiation

et al. 2018

View full text Add to dashboard Cite

Bimetallic nanoalloys with a wide variety of structures and compositions have been fabricated through many diverse techniques. Generally, various steps and chemicals are involved in their fabrication. In this study, the synthesis of Ag–Bi nanoalloys by femtosecond laser irradiation of an inorganic oxide Ag 2 WO 4 /NaBiO 3 target without any chemicals like reducing agents or solvent is presented. The interaction between these materials and the ultrashort pulse of light allows the migration of Ag and Bi atoms from the crystal lattice to the particles surfaces and then to the plasma plume, where the reduction of the positively charged Ag and Bi species in their respective metallic species takes place. Subsequently, the controlled nucleation and growth of the Ag–Bi alloyed nanoparticles occurs in situ during the irradiation process in air. Although at the bulk level, these elements are highly immiscible, it was experimentally demonstrated that at nanoscale, the Ag–Bi nanoalloy can assume a randomly mixed structure with up to 6 ± 1 atom % of Bi solubilized into the face-centered cubic structure of Ag. Furthermore, the Ag–Bi binary system possesses high antibacterial activity against Staphylococcus aureus (methicillin-resistant and methicilin-susceptible), which is interesting for potential antimicrobial applications, consequently increasing their range of applicability. The present results provide potential insights into the structures formed by the Ag–Bi systems at the nanoscale and reveal a new processing method where complex inorganic oxides can be used as precursors for the controlled synthesis of alloyed bimetallic nanoparticles.

show abstract

Section: Results and Discussionmentioning

confidence: 94%

From Complex Inorganic Oxides to Ag–Bi Nanoalloy: Synthesis by Femtosecond Laser Irradiation

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The antiparasitic effects of bismuth lipophilic nanoparticles (BisBAL NPs) against Trichomonas vaginalis were recently evaluated. The results showed that after 24 h of ex-position to 500 µg mL −1 of BisBAL NPs, the Trichomonas vaginalis growth was inhibited more than 90%, with efficacy similar to metronidazole at 1.3 µg mL −1 , the reference drug [115,116]. This finding is noteworthy because Trichomonas vaginalis is the most common vaginal parasitosis in women worldwide, with about 5% of the trichomoniasis clinical cases being caused by parasites resistant to metronidazole.…”

Section: Antiparasitic Activitymentioning

confidence: 84%

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Rosário,

Moreira,

Rosa

et al. 2023

Molecules

View full text Add to dashboard Cite

Bismuth-based drugs have been used primarily to treat ulcers caused by Helicobacter pylori and other gastrointestinal ailments. Combined with antibiotics, these drugs also possess synergistic activity, making them ideal for multiple therapy regimens and overcoming bacterial resistance. Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments. As a result, there is a growing interest in developing new bismuth compounds and approaches to overcome this challenge. Considering the beneficial properties of bismuth and the importance of discovering new drugs, this review focused on the last decade’s updates involving bismuth compounds, especially those with potent activity and low toxicity, desirable characteristics for developing new drugs. In addition, bismuth-based compounds with dual activity were also highlighted, as well as their modes of action and structure–activity relationship, among other relevant discoveries. In this way, we hope this review provides a fertile ground for rationalizing new bismuth-based drugs.

show abstract

“…The antiparasitic activity of BisBAL NPs on Trichomonas vaginalis was recently studied by Rodríguez-Luis et al [42] Trichomonas vaginalis is the major cause of vaginitis, cervicitis and urethritis in women worldwide. New treatments are expected, because 5% of the trichomoniasis clinical cases are caused by parasites resistant to the reference drug (metronidazole).…”

Section: Bisbal Npsmentioning

confidence: 99%

Medical Applications of Metallic Bismuth Nanoparticles

et al. 2021

View full text Add to dashboard Cite

Recent reviews described the efficient syntheses of metallic bismuth nanoparticles. Nevertheless, few studies have been published on the medical applications of these nanoparticles compared to the number of studies on the well-documented clinical use of the bismuth(III) complex. An analysis of the literature revealed the significant potential of metallic bismuth nanoparticles in different theranostic applications. In the diagnostic field, preclinical proofs of concept have been demonstrated for X-ray, photoacoustic and fluorescence imaging. In the therapeutic field, several preclinical studies have shown the potential of bismuth nanoparticles as X-ray radiosensitizers for use in radiotherapy and as photothermal agents for applications in near infrared phototherapy. The properties of these metallic bismuth nanoparticles as bactericidal, fungicidal, antiparasitic and antibiofilm agents have also been studied. Although information concerning the toxic effects of these nanoparticles has been collected, these data are insufficient when considering the immediate clinical use of these new nanoparticles.

show abstract

Effect of Bismuth Lipophilic Nanoparticles (BisBAL NPs) on Trichomonas vaginalis Growth

Cited by 7 publications

References 0 publications

From Complex Inorganic Oxides to Ag–Bi Nanoalloy: Synthesis by Femtosecond Laser Irradiation

From Complex Inorganic Oxides to Ag–Bi Nanoalloy: Synthesis by Femtosecond Laser Irradiation

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Medical Applications of Metallic Bismuth Nanoparticles

Contact Info

Product

Resources

About