Effect of biotin deficiency on embryonic development in the domestic fowl

Cravens, W. W.; McGibbon, W. H.; Sebesta, E. E.

doi:10.1002/ar.1090900109

Cited by 51 publications

(17 citation statements)

References 15 publications

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“…3A) are examined in the Discussion. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] were incubated with Drosophila homogenates and biocytin to conduct in vitro biotinylation (0 h = before incubation; 1 h = 1 hour after incubation); a negative control (denoted -; C-terminal aa from histone H3) and a positive control (denoted +; chemically biotinylated peptide from histone H4) were also incubated with homogenate and biocytin for 1 hour. Samples were electrophoresed and biotin in transblots was probed using streptavidin peroxidase.…”

Section: Biotinylation Of Histonesmentioning

confidence: 99%

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Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

Landenberger

Kabil

Harshman

et al. 2004

The Journal of Nutritional Biochemistry

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Biotin deficiency is associated with fetal malformations and activation of cell survival pathways in mammals. In this study we determined whether biotin status affects life span, stress resistance, and fertility in the fruit fly Drosophila melanogaster. Male and female flies of the Canton-S strain had free access to diets containing 6.0 (control), 4.8, 2.5, or 0 pmol biotin/100 mg. Biotin concentrations in diets correlated with activities of biotin-dependent propionyl-CoA carboxylase and biotin concentrations in fly homogenates, but not with biotinylation of histones (DNA-binding proteins). Propionyl-CoA carboxylase activities and biotin concentrations were lower in males than in females fed diets low in biotin. The life span of biotin-deficient males and females was up to 30% shorter compared to biotinsufficient controls. Exposure to oxidative stress reversed the effects of biotin status on survival in male flies: survival times increased by 40% in biotin-deficient males compared to biotin-sufficient controls. Biotin status did not affect survival of females exposed to oxidative stress. Exposure of flies to cold, heat, and oxidative stress was associated with mobilization of biotin from yet unknown sources. Biotin deficiency decreased fertility of flies. When biotin-deficient males and females were mated, the hatching rate (larvae hatched per egg) decreased by about 28% compared to biotin-2 sufficient controls. These findings are consistent with the hypothesis that biotin affects life span, stress resistance, and fertility in fruit flies.

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Section: Biotinylation Of Histonesmentioning

confidence: 99%

“…For example, chickens and turkeys with marginal biotin deficiency produce eggs with higher embryonic mortality and reduced hatchability [16][17][18][19]. Likewise, in some strains of mice, biotin deficiency during pregnancy causes a substantial increase in fetal malformations and mortality [14,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

Landenberger

Kabil

Harshman

et al. 2004

The Journal of Nutritional Biochemistry

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“…In reproductive function, biotin deficiency has long been known to induce morphological anomalies in hatchings of fowl ( 9 ). In mammals, biotin has been recently reported to maintain pregnancy and embryonic development (10)(11)(12)(13).…”

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confidence: 99%

Roles of Biotin in Growing Ovarian Follicles and Embryonic Development in Domestic Fowl

Taniguchi

Watanabe

2007

J Nutr Sci Vitaminol

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Summary It is well known that biotin deficiency causes morphological anomalies in hatchlings of fowl. An abundance of biotin in the yolk, therefore, is greatly required for maintaining reproductive functions. Although there is growing evidence for the molecular significance of the vitamin in the processes of the reproductive system in mammals, little is known about its use and roles in fowl's yolk. This review focuses on studies on the roles of biotin in the ovarian follicles and embryos of domestic fowl. Recent studies from our laboratory showed an analysis of the mechanism of biotin supply from the maternal body to follicles, or the yolk using the eggs of domestic fowl. In growing ovarian follicles, biotin was incorporated into the follicles, particularly in a large amount immediately before ovulation. Biotin incorporated from the early stage to the growth stage of ovarian follicles was stored in the protein-binding form and became free biotin again immediately before ovulation. This may be because the biotin necessary for the maintenance of embryonic growth and development should be used immediately after fertilization. In embryos, free biotin in the yolk increased shortly after fertilization. A large amount of free biotin was incorporated into the embryo at the age of 3-4 d. Biotin supply to the embryo differed among embryonic growth stages and organs, suggesting involvement in the formation of each tissue and organ. Thus, a large amount of biotin was utilized for embryonic growth, suggesting its important role in normal embryonic growth. These findings show that biotin is an essential nutrient and may play a major role in the normal morphogenesis of embryos in domestic fowl.

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“…Frigg et al (1973) and Cook et al (1984 a, b) confirmed the involvement of biotin in abnormal development of leg bone in young chicken and turkeys. Earlier reports by Cravens et al (1944) andCouch et al (1948) indicated that skeletal deformities, perosis, chondrodystrophy, crooked tibia and shortened or twisted tarsometatarsus were observed in dead embryos and newly hatched chicks when the breeding flock was fed a biotin -defiicient diet. In this study, leg bone abnormalities developed in experimental chicks fed 40-160 meg biotin/kg dehulled SSM based diets, and those fed 40-200 meg biotin/kg non-dehulled SSM based diet (Table 3).…”

Section: Resultsmentioning

confidence: 97%

Studies on the biotin requirement of broilers fed sunflower seed meal based diets

Oloyo

1994

Archiv für Tierernaehrung

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A total of 560 day-old commercial broiler chicks were used in two experiments conducted to investigate the biotin requirement of broilers fed sunflower seed meal (SSM) based diets. Two basal biotin-deficient diets based on dehulled (Experiment 1) and non-dehulled (Experiment 2) SSM were each supplemented with graded levels of biotin so that the rations had 40, 80, 120, 160, 200, 240 and 280 mcg/kg feed. Therefore a total of 14 treatments were tested. Each treatment was given to duplicate floor pens with 20 chicks each for a period of 28 days. Estimation of the live weights, live weight gain, feed intake, blood glucose and free fatty acid concentrations, lipid contents and weights of liver and kidney, and liver pyruvate carboxylase activity and the records of incidence of dermal lesions, fatty liver and kidney syndrome (FLKS) mortality and leg deformities indicated that in the case of dehulled SSM, dietary biotin of of 160 mcg/kg feed was marginal while at least 200 mcg/kg appeared to be needed for optimum performance of the birds. When non-dehulled SSM was incorporated in the diet, 200 mcg biotin/kg feed was found to be the lowest dietary level needed. However, as it seems that better results could be obtained with higher levels, 240 mcg biotin/kg with non-dehulled SSM is being recommended.

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Effect of biotin deficiency on embryonic development in the domestic fowl

Cited by 51 publications

References 15 publications

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

Roles of Biotin in Growing Ovarian Follicles and Embryonic Development in Domestic Fowl

Studies on the biotin requirement of broilers fed sunflower seed meal based diets

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