Effect of bioglass additions on the sintering of Y-TZP bioceramics

Habibe, Alexandre Fernandes; Maeda, L.D.; Souza, Renato Chaves; Barboza, M.J.R.; Daguano, J.K.M.F.; Rogero, Sizue Ota; Santos, Claudinei dos

doi:10.1016/j.msec.2009.03.006

Cited by 28 publications

(16 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, it was postulated that the use of combinatory materials for the design of drug release systems has the potential for improving drug bioavailability together with predictable release kinetics. Many efforts have been directed toward the development of biodegradable composite materials for drug delivery and targeted controlled release in terms of reproducible and predictable release kinetics in order to meet the therapeutic demands (Ginebra et al, 2006 ; Habibe et al, 2009 ; Zhang et al, 2017 ; Li J. et al, 2018a , b ; Li S. et al, 2018 ; Zhang W. et al, 2018a , b ; Zhang Y. et al, 2018 ). Previous studies showed that bulk eroding polymeric materials show a drug release pattern ranging from one stage (Schmidt et al, 1995 ; Krasko et al, 2007 ; Billon-Chabaud et al, 2010 ; Morawska-Chochółet al, 2014 ), three stages (Schnieders et al, 2006 ; Xu and Czernuszka, 2008 ; Gosau and Müller, 2010 ) to four stages (Shen et al, 2002 ; Takenaga et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery From Polymer-Based Nanopharmaceuticals—An Experimental Study Complemented by Simulations of Selected Diffusion Processes

Macha

Ben‐Nissan

Иванова

et al. 2019

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The success of medical therapy depends on the correct amount and the appropriate delivery of the required drugs for treatment. By using biodegradable polymers a drug delivery over a time span of weeks or even months is made possible. This opens up a variety of strategies for better medication. The drug is embedded in a biodegradable polymer (the “carrier”) and injected in a particular position of the human body. As a consequence of the interplay between the diffusion process and the degrading polymer the drug is released in a controlled manner. In this work we study the controlled release of medication experimentally by measuring the delivered amount of drug within a cylindrical shell over a long time interval into the body fluid. Moreover, a simple continuum model of the Fickean type is initially proposed and solved in closed-form. It is used for simulating some of the observed release processes for this type of carrier and takes the geometry of the drug container explicitly into account. By comparing the measurement data and the model predictions diffusion coefficients are obtained. It turns out that within this simple model the coefficients change over time. This contradicts the idea that diffusion coefficients are constants independent of the considered geometry. The model is therefore extended by taking an additional absorption term into account leading to a concentration dependent diffusion coefficient. This could now be used for further predictions of drug release in carriers of different shape. For a better understanding of the complex diffusion and degradation phenomena the underlying physics is discussed in detail and even more sophisticated models involving different degradation and mass transport phenomena are proposed for future work and study.

show abstract

Section: Introductionmentioning

confidence: 99%

Drug Delivery From Polymer-Based Nanopharmaceuticals—An Experimental Study Complemented by Simulations of Selected Diffusion Processes

Macha

Ben‐Nissan

Иванова

et al. 2019

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Habide et al (2009) estudiaron el efecto de la adición de vidrio bioactivo en biocerámicas de compuestos sinterizados de itria y circonio; en esta investigación se determinó que hubo una disminución en la citotoxicidad, pero también en la dureza y la resistencia a la fractura. Se realizó un estudio de adición de biovidrio 45S5 a hidroxiapatita con el fin de mejorar la proliferación y transformación en apatita de los osteoblastos; en este proyecto sinterizaron ambos compuestos y se realizaron diferentes estudios a nivel celular para medir la influencia del vidrio en la estructura de la matriz de hidroxiapatita obteniendo una mejora substancial en las propiedades de biocompatibilidad por parte del compuesto en relación al comportamiento de la hidroxapatita.…”

Section: Biovidrio Como Aplicación En El Reemplazo De Tejido óSeounclassified

Revisión del comportamiento biocompatible de biovidrio como material promisorio en la industria biomédica

Cordoba

Delgado

2015

Inf. Téc.

View full text Add to dashboard Cite

This article aims to show how the bioglass has been important in the development of biomedical sciences from its applicability and versatility in its multiple uses. This review aims to show how through interdisciplinary research it has designed different processes for obtaining materials from bioactive glasses. First, we will discuss the importance of development of biomedical devices focused in bioglass as precursor material and its impact on society today. Subsequently, relevance and importance of the surface modification as mechanism to improve working Review of biocompatibility behavior of bioglass as promising material in biomedical industryRevisión del comportamiento biocompatible de biovidrio como material promisorio en la industria biomédica

show abstract

“…In order to lower the sintering temperature of ZrO 2 , additives are deliberately introduced such as Fe 2 O 3 , SiO 2 , Al 2 O 3 , TiO 2 , and others [8]. There are some reports [9,10] concerning the effect of bioglass additives on the sintering behaviour of ZrO 2 ; some glass compositions result in improved densification of ZrO 2 via liquid phase sintering, other ones enhanced the ZrO 2 solid state sintering.…”

Section: Introductionmentioning

confidence: 99%