Effect of bioactive glass-containing resin composite on dentin remineralization

Jang, Jung‐Hee; Lee, Myoung Geun; Ferracane, Jack L.; Davis, Harry B.; Bae, Han Eul; Choi, Dongseok; Kim, Duck-Su

doi:10.1016/j.jdent.2018.05.017

Cited by 50 publications

(48 citation statements)

References 33 publications

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“…Studies verifying the effect of pre-polymerized resin-based materials containing ion-releasing fillers placed on demineralized dentin samples provide further evidence of mineral precipitation within the collagen network. A composite containing 15 wt% of BAG and 57 wt% of reinforcing fillers were able to increase by 25% the surface microhardness of demineralized bovine dentin (37% phosphoric acid gel for 60 s) after two week of immersion in SBF or PBS, although not to the same level displayed by non-demineralized dentin samples 23) . Fully demineralized human dentin beams (10% phosphoric acid gel for 12 h) kept in contact with composite bars containing 50 wt% of fluoride-containing BAG for 30 days in AS showed a 13% increase in elastic modulus, while those in contact with the control resin showed a reduction of 32% 22) .…”

Section: Mechanical Properties Of Demineralized Dentin and Adhesive Imentioning

confidence: 86%

“…Ion-releasing ("bioactive") particles have been tested as additives in experimental [18][19][20][21][22][23] and commercial adhesives 24) . Also, they have been applied to acid-etched dentin prior to adhesive application 19,25,26) or used in airabrasion systems for selective caries removal 27) .…”

Section: Strategies Involving Bioactive Particlesmentioning

confidence: 99%

“…Among the silicabased BAG, the original 45S5 Bioglass, developed by Hench in the late 1960's 33) , is the composition most commonly tested, either unmodified 18,19) , doped with zinc 20,21) , copper 34) , fluoride 22) or treated with polyacrylic acid (PAA) 27) . Other compositions have been tested, including Niobium-based glass 24,25) and a silica-based glass with higher Ca:P molar ratio than 45S5 23) .…”

Section: Strategies Involving Bioactive Particlesmentioning

confidence: 99%

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The use of bioactive particles and biomimetic analogues for increasing the longevity of resin-dentin interfaces: A literature review

Braga

Fronza

2020

Dent. Mater. J.

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Protecting resin-dentin interfaces from hydrolytic and enzymatic degradation is critical for the longevity of adhesive restorations. In recent years, several strategies have been tested in vitro to induce apatite precipitation within interfibrillar and intrafibrillar collagen spaces, as well as in resin-sparse regions where the adhesive infiltration was incomplete. Also, the presence of calcium ions and other metallic ions has shown an inhibitory effect on enzymatic activity. Ion-releasing particles and biomimetic analogs have been studied for hybrid layer remineralization. Overall, remineralization strategy is dependent on the remaining mineral content. In partially demineralized dentin, residual apatite crystallites serve as nucleation sites for calcium and phosphate ions precipitation and crystal growth ("top-down" remineralization). In completely demineralized dentin where crystallites are absent (e.g., acid etched dentin) the use of mineral nano-precursors assisted by non-collagenous proteins analogs are necessary ("bottom-up" remineralization). This article reviews the approaches for hybrid layer remineralization and resin-dentin interface preservation.

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Section: Mechanical Properties Of Demineralized Dentin and Adhesive Imentioning

confidence: 86%

Section: Strategies Involving Bioactive Particlesmentioning

confidence: 99%

Section: Strategies Involving Bioactive Particlesmentioning

confidence: 99%

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The use of bioactive particles and biomimetic analogues for increasing the longevity of resin-dentin interfaces: A literature review

Braga

Fronza

2020

Dent. Mater. J.

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“…The incorporation of bioglass 65S into a dentin desensitizer can reduce fluid flow in dentinal tubules, resulting in reduced dentinal hypersensitivity 78) . Jang et al 79) revealed that the incorporation of 65S significantly increased the micro-hardness of the adjacent demineralized dentin, and calcium phosphate peaks on the dentin could be detected by attenuated total reflection Fouriertransform infrared spectroscopy (ATR-FTIR) analysis. These findings suggest that resin composites containing 65S can remineralize adjacent demineralized dentin.…”

Section: Ion-releasing Glass Fillersmentioning

confidence: 99%

Cutting-edge filler technologies to release bio-active components for restorative and preventive dentistry

et al. 2020

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Advancements in materials used for restorative and preventive treatment is being directed toward "bio-active" functionality. Incorporation of filler particles that release active components is a popular method to create bio-active materials, and many approaches are available to develop fillers with the ability to release components that provide "bio-protective" or "bio-promoting" properties; e.g. metal/calcium phosphate nanoparticles, multiple ion-releasing glass fillers, and non-biodegradable polymer particles. In this review paper, recent developments in cutting-edge filler technologies to release bio-active components are addressed and summarized according to their usefulness and functions, including control of bacterial infection, tooth strengthening, and promotion of tissue regeneration.

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“…4,5 Biomimetic dentin remineralization, a valuable tool for maintaining the mechanical properties and biostability of collagen fibrils, is an emerging biomedical technology for improving the durability of the bond strength. [6][7][8] Remineralization of demineralized dentin may reduce collagen degradation, [9][10][11] and specific agents have been used for this purpose.…”

mentioning

confidence: 99%

Effect of polyvinylphosphonic acid on resin-dentin bonds and the cytotoxicity of mouse dental papilla cell-23

Xie

Cao

et al. 2019

The Journal of Prosthetic Dentistry

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Statement of problem. Polyvinylphosphonic acid (PVPA) could be used as a biomimetic remineralization analog and a matrix metalloproteinases (MMPs) inhibitor. However, studies are lacking regarding the performance of PVPA in dental bonding systems for maintaining the durability of the resin-dentin bond.Purpose. The purpose of this in vitro study was to investigate the effect of PVPA on the durability of resin-dentin bonds and the viability of mouse dental papilla cell-23 (MDPC-23). The mechanical properties of resin-dentin interfaces during long-term storage were analyzed, and the potential application of PVPA as a biomimetic remineralization analog in adhesive dentistry was evaluated.Material and methods. Seventy-five extracted noncarious human third molars were collected and randomly divided into 5 groups, and then the microtensile bond strength (mTBS) data and scanning electron microscope (SEM) images were used to evaluate the preservation condition of resin-dentin bonds after 1 day, 6 months, and 1 year of storage. The cytotoxicity of PVPA was detected by cell proliferation assay and cell apoptosis assay.Results. Compared with the control and chlorhexidine (CHX) groups, the combined group (treated with both 200-mg/mL PVPA and biomimetic remineralization) had excellent bond durability. The exposed collagen fibril from the PVPA-treated groups (included 200-mg/mL and 500-mg/mL PVPA groups and a combined group) still showed integrity after 1 year of storage when compared with the control group. PVPA up to 500 mg/mL showed no cytotoxicity to MDPC-23 and did not inhibit cell growth.Conclusions. This study offered evidence that PVPA did not result in cytotoxicity at low concentrations as an MMP inhibitor and a biomimetic remineralization analog. In addition, the application of PVPA improved bond strength and preserved collagen integrity after 1 year of in vitro storage. (J Prosthet Dent 2019;122:492.e1-e6) 492.e1 THE JOURNAL OF PROSTHETIC DENTISTRY

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Effect of bioactive glass-containing resin composite on dentin remineralization

Cited by 50 publications

References 33 publications

The use of bioactive particles and biomimetic analogues for increasing the longevity of resin-dentin interfaces: A literature review

The use of bioactive particles and biomimetic analogues for increasing the longevity of resin-dentin interfaces: A literature review

Cutting-edge filler technologies to release bio-active components for restorative and preventive dentistry

Effect of polyvinylphosphonic acid on resin-dentin bonds and the cytotoxicity of mouse dental papilla cell-23

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