Effect of bile acids on absorption of nitrendipine in healthy subjects

Sato, Masato; Maeda, Akira; Sakamoto, Koichi; Fujimura, Akio

doi:10.1046/j.0306-5251.2001.01489.x

Cited by 14 publications

(9 citation statements)

References 9 publications

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“…The disposition of nitrendipine decreased significantly during UDCA administration. 107 As nitrendipine is a substrate of CYP3A4, 108, 109 a metabolic drug interaction is assumed. Dapsone was successfully administered for the control of dermatitis herpetiformis in a 61-year-old man.…”

Section: Drug Interactionsmentioning

confidence: 99%

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Ursodeoxycholic acid — adverse effects and drug interactions

Hempfling¹,

Dilger

Beuers³

2003

Aliment Pharmacol Ther

100

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SUMMARYBackground: Ursodeoxycholic acid is increasingly being used for the treatment of chronic cholestatic liver diseases. It appears to be generally well tolerated, but a systematic review on drug safety is lacking. Aim: As experimental data suggest a role of bile acids in the regulation of hepatic drug metabolism at both the transcriptional and post-transcriptional level, the literature was screened for adverse drug reactions and drug interactions related to ursodeoxycholic acid. Methods: A systematic review of the literature was performed using a refined search strategy to evaluate the adverse effects of ursodeoxycholic acid and its interactions with other drugs. Results: Ursodeoxycholic acid caused diarrhoea in a small proportion of patients. Rare skin reactions were

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Section: Drug Interactionsmentioning

confidence: 99%

“…The pharmacokinetics of nitrendipine, a highly lipophilic calcium channel blocker, were affected by UDCA in a controlled clinical study. The disposition of nitrendipine decreased significantly during UDCA administration 107 . As nitrendipine is a substrate of CYP3A4, 108 , 109 a metabolic drug interaction is assumed.…”

mentioning

confidence: 99%

Ursodeoxycholic acid — adverse effects and drug interactions

Hempfling¹,

Dilger

Beuers³

2003

Aliment Pharmacol Ther

100

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“…91 Administration of exogenous bile was accompanied by decreased oral bioavailability of atenolol 95 and nitrendipine. 96 It was suggested that coadministration of exogenous unconjugated BSs (such as ursodeoxycholic acid and CDCA) with drug formulation decreases the function of endogenous more soluble BS conjugates.…”

Section: Paradoxical Effects Of Bsmentioning

confidence: 99%

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Elnaggar¹

2015

IJN

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The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs’ metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs’ potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined.

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“…Bile acids have been shown to be important regulators in drug disposition 19 and the CYP7A1 gene is the initial and rate limiting step in the catabolism of cholesterol to bile acids 20 . Previous research has shown that the level of bile acids can alter the blood concentrations across multiple lipophilic drugs when given orally, which therefore impact the pharmacokinetic parameters of the drug 21–23 . Furthermore, fenbendazole is eliminated through bile into feces in rats and mice 24 and therefore any alterations in the level of bile salts could alter clearance of the drug.…”

Section: Discussionmentioning

confidence: 99%

Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver

Howard

Ashwell

Baynes

et al. 2017

Sci Rep

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Identifying individual genetic variation in drug metabolism pathways is of importance not only in livestock, but also in humans in order to provide the ultimate goal of giving the right drug at the right dose at the right time. Our objective was to identify individual genes and gene networks involved in metabolizing fenbendazole (FBZ) and flunixin meglumine (FLU) in swine liver. The population consisted of female and castrated male pigs that were sired by boars represented by 4 breeds. Progeny were randomly placed into groups: no drug (UNT), FLU or FBZ administered. Liver transcriptome profiles from 60 animals with extreme (i.e. fast or slow drug metabolism) pharmacokinetic (PK) profiles were generated from RNA sequencing. Multiple cytochrome P450 (CYP1A1, CYP2A19 and CYP2C36) genes displayed different transcript levels across treated versus UNT. Weighted gene co-expression network analysis identified 5 and 3 modules of genes correlated with PK parameters and a portion of these were enriched for biological processes relevant to drug metabolism for FBZ and FLU, respectively. Genes within identified modules were shown to have a higher transcript level relationship (i.e. connectivity) in treated versus UNT animals. Investigation into the identified genes would allow for greater insight into FBZ and FLU metabolism.

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Effect of bile acids on absorption of nitrendipine in healthy subjects

Cited by 14 publications

References 9 publications

Ursodeoxycholic acid — adverse effects and drug interactions

Ursodeoxycholic acid — adverse effects and drug interactions

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver

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