Effect of bilateral hippocampal ablation on DRL performance.

Clark, Carol V. H.; Isaacson, Robert L.

doi:10.1037/h0021599

Cited by 258 publications

(79 citation statements)

References 13 publications

(11 reference statements)

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“…First, in order to perform weIl on this schedule, an animal must learn to withhold a bar-pressing response. Second, data are available for comparative purposes on the effects of septa1 (Ellen, Wilson & Powell, 1964) and hippocampal (Clark & Isaacson, 1965;Schmaltz & Isaacson, 1966) lesions on DRL performance.…”

Section: Resultsmentioning

confidence: 99%

Amygdaloid lesions and behavioral inhibition in the rat.

Pellegrino¹

1968

Journal of Comparative and Physiological Psychology

134

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Rats with bilateral lesions of the basolateral region of the amygdala were impaired in passive avoidance, DRL performance, and spatial alternations without cues, but not in visually cued spatial alternations or go-no-go visual discriminations and reversals. Except for a small deficit in passive avoidance, rats with lesions in the corticomedial region of the amygdala were not impaired in these tasks. Deficits produced by basolateral lesions can not readily be attributed to increased motivation for food or water. Results suggest that rats with basolateral amygdaloid lesions are unable to inhibit established responses when they must depend on information provided by internal cues.1 This report is based on a dissertation submitted to McGill University in partial fulfillment of the requirements for the PhD degree. The author wishes to thank his thesis adviser, R. B.

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Section: Resultsmentioning

confidence: 99%

Amygdaloid lesions and behavioral inhibition in the rat.

Pellegrino¹

1968

Journal of Comparative and Physiological Psychology

134

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“…Furthermore, the idea of the hippocampus as part of a behavioural inhibition system pre-dates even the cognitive map hypothesis [113][114][115][116][117] .…”

Section: What Is Anxiety?mentioning

confidence: 99%

Hippocampal synaptic plasticity, spatial memory and anxiety

et al. 2014

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. (2014) 'Hippocampal synaptic plasticity, spatial memory and anxiety.', Nature reviews neuroscience., 15 (3). pp. 181-192. Further information on publisher's website:https://doi.org/10.1038/nrn3677Publisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractRecent studies with transgenic mice lacking NMDARs in the hippocampus challenge head-on the longstanding hypothesis that hippocampal LTP-like mechanisms underlie the encoding and storage of associative, long-term spatial memories. However, it may not be the synaptic plasticity/memory hypothesis that is wrong. Instead, it may be the role of the hippocampus that needs re-examination. We present an account of hippocampal function which explains its role in both memory and anxiety.3

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“…These results are in contrast to earlier fail!lres to find a NCE in hippocampal Ss (Franchina & Brown, 1971;Murphy & Brown, 1970). It was proposed that the immediate feedback inherent in the licking response resulted in the standard contrast effect not found when longer ITIs are introduced.The effect of hippocampal lesions has often been characterized as a loss of behavioral inhibition, resulting in increased activity levels (Teitelbaum & Milner, 1963) and slower behavioral adjustment to reinforcement schedule changes (Clark & Isaacson, 1965;Jarrard, 1965;Niki, 1965)_ Consistent with this, hippocampal rats fail to show any behavioral modification of a running response after shifts in incentives (Franchina & Brown, 1971). However, these Ss do show the typical magnitude of reward effects during the preshift-acquisition phase.…”

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confidence: 94%

“…The effect of hippocampal lesions has often been characterized as a loss of behavioral inhibition, resulting in increased activity levels (Teitelbaum & Milner, 1963) and slower behavioral adjustment to reinforcement schedule changes (Clark & Isaacson, 1965;Jarrard, 1965;Niki, 1965)_ Consistent with this, hippocampal rats fail to show any behavioral modification of a running response after shifts in incentives (Franchina & Brown, 1971). However, these Ss do show the typical magnitude of reward effects during the preshift-acquisition phase.…”

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confidence: 94%

The effects of dorsal hippocampal lesions on reinforcement shifts

1973

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This experiment attempted to clarify the effects of dorsal hippocampal lesions on a lick-rate response to reinforcement shifts. Rats received preshift solutions of either 4% or 32% sucrose and were then shifted to the opposite concentration. The results indicated (1) that Ss shifted to the increased concentration quickly adjusted to the control levels. and (2) a negative contrast effect (NCE) for both hippocampal and sham downshift groups. These results are in contrast to earlier fail!lres to find a NCE in hippocampal Ss (Franchina & Brown, 1971;Murphy & Brown, 1970). It was proposed that the immediate feedback inherent in the licking response resulted in the standard contrast effect not found when longer ITIs are introduced.The effect of hippocampal lesions has often been characterized as a loss of behavioral inhibition, resulting in increased activity levels (Teitelbaum & Milner, 1963) and slower behavioral adjustment to reinforcement schedule changes (Clark & Isaacson, 1965;Jarrard, 1965;Niki, 1965)_ Consistent with this, hippocampal rats fail to show any behavioral modification of a running response after shifts in incentives (Franchina & Brown, 1971). However, these Ss do show the typical magnitude of reward effects during the preshift-acquisition phase. In contrast, Murphy and Brown (1970), using a licking response, found rapid behavioral adjustment to a decreased reward, but failed to find any evidence of the well-documented negative contrast effect (NCE; Black, 1968;Vogel, Mikulka, & Spear, 1968)_ Murphy and Brown also found that the same Ss did not display any preference for varying sucrose concentrations in preference tests, but did respond appropriately during the preshift phase.The present experiment was conducted fo examine the effects of dorsal hippocampal lesions on lick rates after reward shifts. The lesions used in this study were considerably more localized than the complete hippocampal aspirations used by Franchina and Brown (I 971) and Murphy and Brown (1970)_ Furthermore, this design used a symmetrical shift paradigm, while Murphy and Brown (I970) only shifted their Ss to lower reward levels. It might be expected that response differences due to hippocampal lesions might be symmetrical, as was found by Franchina and Brown (1971)_ METHOD SubjectsThe Ss were 40 adult male hooded rats of the Long-Evans strain, approximately 180 days old at the start of the experiment. SurgeryAll Ss were anesthetized with an intraperitoneal injection of *All reprint requests should be sent to the second author, Psychology Department, Old Dominion University, Norfolk, Virginia 23508. sodium pentobarbital (50 mg/kg), and 20 rats received hippocampal radio-frequency lesions using the bregma as the zero point. The lesion coordinates were: AP -3.4. ML 3.0, DV 3.5. The remaining 20 rats received sham operations consisting of opening the scalp and drilling two holes in the skull. All Ss were injected with .1 cc of atropine prior to surgery to reduce congestion. After surgery, the Ss were given a .1O-cc injection of pe...

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Effect of bilateral hippocampal ablation on DRL performance.

Cited by 258 publications

References 13 publications

Amygdaloid lesions and behavioral inhibition in the rat.

Amygdaloid lesions and behavioral inhibition in the rat.

Hippocampal synaptic plasticity, spatial memory and anxiety

The effects of dorsal hippocampal lesions on reinforcement shifts

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