Effect of betulinic acid on intracellular-free Ca2+ levels in Madin Darby canine kidney cells

Chou, Kang Ju; Fang, Hua; Chung, Hsiao Min; Cheng, Jin; Lee, Kam Chung; Tseng, Li Ling; Tang, Kwong Yui; Jan, Chung Ren

doi:10.1016/s0014-2999(00)00750-0

Cited by 24 publications

(18 citation statements)

References 30 publications

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“…In vitro studies utilizing Madin Darby kidney cells did reveal that betulinic acid is responsible for a significant increase in the concentration of intracellular-free calcium; however, the increase in free calcium levels was associated with only a slight decrease in cell viability. 121 Based on these findings, it appears that betulinic acid possesses very little broad cytotoxicity, if any, at relatively high therapeutic doses.…”

Section: T O X I C I T Y O F B E T U L I N I C a C I Dmentioning

confidence: 99%

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

Cichewicz

Kouzi

2003

Medicinal Research Reviews

476

220

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3beta-Hydroxy-lup-20(29)-en-28-oic acid (betulinic acid) is a pentacyclic lupane-type triterpene that is widely distributed throughout the plant kingdom. A variety of biological activities have been ascribed to betulinic acid including anti-inflammatory and in vitro antimalarial effects. However, betulinic acid is most highly regarded for its anti-HIV-1 activity and specific cytotoxicity against a variety of tumor cell lines. Interest in developing even more potent anti-HIV agents based on betulinic acid has led to the discovery of a host of highly active derivatives exhibiting greater potencies and better therapeutic indices than some current clinical anti-HIV agents. While its mechanism of action has not been fully determined, it has been shown that some betulinic acid analogs disrupt viral fusion to the cell in a post-binding step through interaction with the viral glycoprotein gp41 whereas others disrupt assembly and budding of the HIV-1 virus. With regard to its anticancer properties, betulinic acid was previously reported to exhibit selective cytotoxicity against several melanoma-derived cell lines. However, more recent work has demonstrated that betulinic acid is cytotoxic against other non-melanoma (neuroectodermal and malignant brain tumor) human tumor varieties. Betulinic acid appears to function by means of inducing apoptosis in cells irrespective of their p53 status. Because of its selective cytotoxicity against tumor cells and favorable therapeutic index, even at doses up to 500 mg/kg body weight, betulinic acid is a very promising new chemotherapeutic agent for the treatment of HIV infection and cancer.

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Section: T O X I C I T Y O F B E T U L I N I C a C I Dmentioning

confidence: 99%

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

Cichewicz

Kouzi

2003

Medicinal Research Reviews

476

220

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“…N. nucifera is reported to possess antidiarrheal and antimicrobial properties (Mukherjee et al 1995;Mukherjee 2002). It has been reported that this plant contain betulinic acid, a steroidal pentacyclic triterpenoid, as one of the phytomolecule which has proved to be a potent lead for several pharmacological activities like anti-inflammatory and anti-tumor (Mukherjee et al 1997;Chou et al 2000). Ling et al (2005) reported that the procyanidins were isolated from the seedpods of N. nucifera showing a strong antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors

Santhoshkumar¹,

Rahuman²,

Rajakumar³

et al. 2010

Parasitol Res

388

110

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The aim of this study was to investigate the larvicidal potential of the hexane, chloroform, ethyl acetate, acetone, methanol, and aqueous leaf extracts of Nelumbo nucifera Gaertn. (Nymphaeaceae) and synthesized silver nanoparticles using aqueous leaf extract against fourth instar larvae of Anopheles subpictus Grassi and Culex quinquefasciatus Say (Diptera: Culicidae). Nanoparticles are being used in many commercial applications. It was found that aqueous silver ions can be reduced by aqueous extract of plant parts to generate extremely stable silver nanoparticles in water. The results recorded from UV-vis spectrum, scanning electron microscopy, X-ray diffraction, and Fourier transform infrared support the biosynthesis and characterization of silver nanoparticles. Larvae were exposed to varying concentrations of plant extracts and synthesized silver nanoparticles for 24 h. All extracts showed moderate larvicidal effects; however, the maximum efficacy was observed in crude methanol, aqueous, and synthesized silver nanoparticles against the larvae of A. subpictus (LC(50) = 8.89, 11.82, and 0.69 ppm; LC(90) = 28.65, 36.06, and 2.15 ppm) and against the larvae of C. quinquefasciatus (LC(50) = 9.51, 13.65, and 1.10 ppm; LC(90) = 28.13, 35.83, and 3.59 ppm), respectively. These results suggest that the leaf methanol, aqueous extracts of N. nucifera, and green synthesis of silver nanoparticles have the potential to be used as an ideal eco-friendly approach for the control of the A. subpictus and C. quinquefasciatus. This is the first report on the mosquito larvicidal activity of the plant extracts and synthesized nanoparticles.

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“…It has been reported that this plant has contain betulinic acid, a steroidal pentacyclic triterpenoid, as one of the phytomolecule which has proved to be a potent lead for several pharmacological activities like anti-inflammatory, anti-tumor, etc. (Mukherjee et al, 1997;Chou et al, 2000). Hence the present study was aimed to explore the immunomodulatory potential of extract of rhizome and seeds of Nelumbo nucifera.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn.

Mukherjee¹,

Khatua²,

Venkatesh³

et al. 2010

Journal of Ethnopharmacology

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Effect of betulinic acid on intracellular-free Ca2+ levels in Madin Darby canine kidney cells

Cited by 24 publications

References 30 publications

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors

Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn.

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