Effect of Beta-Casomorphin and Its Analogue on Serum Prolactin in the Rat

Nedvı́dková, J; Kasafírek, E; Dlabac, A; Felt, V

doi:10.1055/s-0029-1210445

Cited by 22 publications

(11 citation statements)

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“…All studies included at least 3154 animals in total (min 6 animals and max 639 animals per study; five studies did not report the exact number of animals included [18][19][20][21][22]). Most studies administered BCM-7 as injection [18][19][20][21][22][23][24][25][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] and ten studies administered it orally [25,[43][44][45][46][47][48][49][50][51]. Most studies provided BCM-7 alone, whereas three studies used a mix of BCM-fragments (including BCM-7) as intervention [25,44,50].…”

Section: Characteristics Of Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

“…Furthermore, three studies found that BCM-7 had a protective effect on diabetic nephropathy in rats [47,51] and on diabetic cardiomyopathy also in rats [43]; and one study reported less free-radicalmediated oxidative stress in the pancreas of rats fed BCM-7 compared to rats without the intervention [46]. Furthermore, results from five studies were grouped under outcomes related to endocrine function [25,26,38,48]. Specifically, somatostatin release was investigated in three studies in dogs [25,26], from which two studies found no effect of BCM-7 administration [25], and one study found a dose-dependent inhibition of somatostatin after the administration of BCM-7 [26].…”

Section: Details Of Interventions and Health Outcomes In Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

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A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

et al. 2021

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Purpose Food-derived bioactive peptides may influence important physiological functions. An important example is beta-casomorphins, which are opioid peptides derived from A1 beta-casein in bovine milk and have been associated to be risk factors for non-communicable diseases in humans. A1 and A2 beta-casein are different with respect to the release of bioactive peptides, in particular BCM-7. However, evidence from human studies is limited and could be complemented with evidence derived from animal studies. We conducted a scoping review to identify animal studies investigating the effects of A1 beta-casein or BCM-7 compared to A2 beta-casein or any other intervention on health-related outcomes. Methods We systematically searched for relevant studies in two electronic databases (Medline, Embase; last search performed March 2020). Two reviewers independently undertook study selection and data extraction of included references. Results were summarized tabularly and narratively. Results We included 42 studies investigating various animal models, including rats, mice, rabbits, and dogs. Six studies investigated health-related outcomes of A1- vs. A2 milk, while most studies (n = 36) reported on physiological properties (e.g., analgesic effect) of BCM-7 as an opioid peptide. Included studies were extremely heterogeneous in terms of the study population, type of intervention and dose, and type of outcome measures. Conclusions Only a few studies comparing the effects of A1- and A2 milk were identified. More studies addressing this research question in animal models are needed to provide essential information to inform research gaps. Results from future studies could eventually complement research for humans, particularly when the body of evidence remains uncertain as is the case in the A1- and A2 milk debate.

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Section: Characteristics Of Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

Section: Details Of Interventions and Health Outcomes In Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

et al. 2021

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“…[6] BCM-7 has a protective role against hyperglycemia and free radical-mediated oxidative stress and inhibited NF-K B-iNOS-nitric oxide signal pathway in the pancreas of diabetic rats. [47] Nedvidková et al [8] observed that BCM-7 increased the prolactin level in plasma after intraperitoneal injection, and this hormone is best known for its role in lactation and as a regulator of the immune system. An analgesic role of BCM-7 by giving intraperitoneal injection of this peptide to the rats was also described.…”

Section: Functional Importance Of Bcm-7mentioning

confidence: 99%

“…[2] Among these, β-casomorphins (BCMs), peptide sequences present in the milk protein β-casein, have been suggested to contribute to an increased risk of cardiovascular diseases, [3] type I diabetes, [4] and sudden infant death syndrome. [5] There are also controversial reports available that show a positive impact of these peptides like their protective role against hyperglycemia and free radical-mediated oxidative stress, [6] mucin gene expression and mucus secretion, [7] increased prolactin levels, [8] and aid in gastric motility by expression of gastrin. [9] Thus, on one hand BCMs are considered devils in the milk, [10] while on the other hand, some beneficial effects of BCMs have also been documented.…”

Section: Introductionmentioning

confidence: 99%

Impact of Milk Derived β-Casomorphins on Physiological Functions and Trends in Research: A Review

Haq

Kapila

Shandilya

et al. 2014

International Journal of Food Properties

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β-Casomorphins are a group of opioid peptides released during gastrointestinal digestion or food processing from the β-casein of milk protein. Consequently, milk can be divided into A1 and A2 "like" groups depending upon the presence or absence of proline or histidine at the 67th position of β-casein. A1 "like" milk is postulated to be a source of BCM-7 as histidine allows the cleavage at this position, while A2 "like" milk has proline that resists the hydrolysis. On one hand, BCM-7 has been implicated as a risk factor for cardiovascular diseases, type I diabetes, and neurological disorders. On the other hand, various physiological effects of these peptides have also been documented, i.e., secretion of mucus, increased activity of superoxide dismutase and catalase, increased levels of prolactin, and analgesic role. In addition, many evidences correlate these peptides with various immunological functions, such as development of innate immunity, lymphocyte proliferation and cellular immunity, role in autoimmune diseases, histamine release, and allergy. In conclusion, the role of β-casomorphins in physiological functions remains controversial and more research with improved diagnostic techniques is needed to unravel the mechanism and study physiological functions of β-casomorphins. Thus, health-related aspects of β-casomorphins (positive, negative, and immunological impacts) have been comprehensively reviewed in this article.

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“…Επιπλέον β-καζοµορφίνες έχουν βρεθεί στο αίµα και στο εγκεφαλονωτιαίο υγρό θηλαζουσών µητέρων. Εικάζεται ότι οι καζοµορφίνες αυτές παίζουν φυσιολογικό ρόλο στη αλληλοεπίδραση ορµονών και αυξητικών παραγόντων στο θηλάζοντα µαστό (Nedvidkova et al 1985). Σε νεογνά βοειδών (Umbach et al 1985) ή σκύλων (Singh et al 1989) έχουν ταυτοποιηθεί πρόδροµες ουσίες ή αυτούσιες β-καζοµορφίνες στον ορό, µετά από τη λήψη γάλακτος.…”

Section: καζοµορφίνεςunclassified

Οπιοειδές Σύστημα Και Καρκίνος Του Προστάτη

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Effect of Beta-Casomorphin and Its Analogue on Serum Prolactin in the Rat

Cited by 22 publications

References 2 publications

A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

Impact of Milk Derived β-Casomorphins on Physiological Functions and Trends in Research: A Review

Οπιοειδές Σύστημα Και Καρκίνος Του Προστάτη

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