Effect of Benzodiazepine Derivatives: I. Augmentation of T Cell-Dependent Antibody Response by Diazepam in Mouse Spleen Cells

Okimura, Tsutomu; Nagata, Ikuo

doi:10.3109/08923978609026493

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…With reference to the influence of BDZ on the immune system, evidence has been provided that diazepam is able to inhibit superoxide production induced by formyl-methionyl-leucyl-phenylalanine (FMLP) (1 1) and phagocytosis and killing exerted by both polymorphonuclear (PMN) cells and monocytes (12). On the contrary, diazepam has been shown to augment antibody synthesis (13). However, this drug does not modify Tcell mediated antibacterial activity (ABA) (1 4).…”

Section: In Trod U Ctlo Nmentioning

confidence: 98%

Triazolobenzodiazepines Exert Immunopotentiating Activities on Normal Human Peripheral Blood Lymphocytes

Jirillo¹,

Maffione²,

Greco

et al. 1993

Immunopharmacology and Immunotoxicology

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Previous studies have demonstrated that benzodiazepines (BDZ) (e.g. diazepam) inhibit immune responsiveness. Since these drugs are largely used in psychiatric patients it is of great importance to verify the existence of different types of BDZ, which are not suppressive for the immune system. In this framework, our results indicate that alprazolam and triazolam, two triazolo-BDZ, do not modify in vitro phagocytosis and killing exerted by normal human polimorphonuclear cells and monocytes. On the contrary, they significantly enhance T lymphocyte-dependent antibacterial activity in normal donors. These data support the concept that triazolo-BDZ and, in particular, alprazolam may represent more appropriate drugs for the treatment of psychiatric patients (e.g. patients with phobic disorders and/or migraine) who display immunodeficits.

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Section: In Trod U Ctlo Nmentioning

confidence: 98%

Triazolobenzodiazepines Exert Immunopotentiating Activities on Normal Human Peripheral Blood Lymphocytes

Jirillo¹,

Maffione²,

Greco

et al. 1993

Immunopharmacology and Immunotoxicology

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show abstract

“…It has been shown that when BDZs are taken at physiological levels, they have immunoprotective effects. BDZs have also been shown to enhance the antibody response through stimulating helper T cell functions in restraint-stressed mice (85). Furthermore, Alprazolam and midazolam can decrease the adverse effect of surgical stress on the thymus and spleen in mice and maintain their cellularity (86,87).…”

Section: Cd8+ T Cells Are An Important Part Of the Immune Response Toward Viral Infection (78) Cd8+ T Cells Rely On Direct (Cell To Cell mentioning

confidence: 99%

Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

et al. 2021

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The HIV-1 pandemic is a significant challenge to the field of medicine. Despite advancements in antiretroviral (ART) development, 38 million people worldwide still live with this disease without a cure. A significant barrier to the eradication of HIV-1 lies in the persistently latent pool that establishes early in the infection. The “shock and kill” strategy relies on the discovery of a latency-reversing agent (LRA) that can robustly reactivate the latent pool and not limit immune clearance. We have found that a benzodiazepine (BDZ), that is commonly prescribed for panic and anxiety disorder, to be an ideal candidate for latency reversal. The BDZ Alprazolam functions as an inhibitor of the transcription factor RUNX1, which negatively regulates HIV-1 transcription. In addition to the displacement of RUNX1 from the HIV-1 5′LTR, Alprazolam potentiates the activation of STAT5 and its recruitment to the viral promoter. The activation of STAT5 in cytotoxic T cells may enable immune activation which is independent of the IL-2 receptor. These findings have significance for the potential use of Alprazolam in a curative strategy and to addressing the neuroinflammation associated with neuroHIV-1.

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Immunoenhancing effects of alprazolam in mice

1990

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Effect of Benzodiazepine Derivatives: I. Augmentation of T Cell-Dependent Antibody Response by Diazepam in Mouse Spleen Cells

Cited by 8 publications

References 17 publications

Triazolobenzodiazepines Exert Immunopotentiating Activities on Normal Human Peripheral Blood Lymphocytes

Triazolobenzodiazepines Exert Immunopotentiating Activities on Normal Human Peripheral Blood Lymphocytes

Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

Immunoenhancing effects of alprazolam in mice

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