Effect of Baypamun® on Blood Leucocytes in Normal and Dexamathasone Treated Goats

Winnicka, A.; Kluciński, W.; Kawiak, Jerzy; G, Hoser; Sikora, Jan

doi:10.1046/j.1439-0442.2000.00298.x

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…Our findings are in accordance with the investigations of Burton and Kehrli [8] who demonstrated that the percentages of CD2 + , CD4 + and CD8 + T cells are not altered by 0.04 mg/kg/ day dexamethasone administered to young bulls on three consecutive days. However, in other studies glucocorticosteroids have been shown to cause lymphopenia and alterations of lymphocyte subsets [2,14,16,42]. Thus, the differences between the results of previous studies and the present one can mainly be explained by the differences in the sort of corticosteroids administered as well as differences in the age of the probands, the dosage regimen and the number of treatments.…”

Section: Discussioncontrasting

confidence: 67%

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

et al. 2004

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-Dexamethasone is a potent therapeutic for treatment of the fatty liver syndrome or primary ketosis in post partum dairy cows. Reservations exist, however, among practitioners with respect to the risk of immunosuppression induced by corticosteroids. The aim of this study was to investigate the effect of a single injection of dexamethasone-21-isonicotinate on distinct immune functions of postpartum dairy cows because only scarce information is available on the effects of corticosteroid preparations when administered at a dosage and frequency for treatment of the fatty liver syndrome or primary ketosis. Sixteen Swedish red-pied dairy cows, between days 9 and 15 post partum, were allotted to either a control group (n = 8) or a treatment group (n = 8). The cows in the treatment group received a single intramuscular injection of a dexamethasone-21-isonicotinate suspension at a dosage of 0.02 mg/kg i.m. at the start of the experiment. White blood cell counts and selected lymphocyte functions (lymphocyte proliferation, expression of lymphocyte markers and the β2 and α4 chain of adhesion molecules belonging to the integrin family) and some parameters of the energy metabolism (glucose, insulin) were determined before the administration of corticosteroids (day 0) and subsequently at days 2, 4, 7 and 9 of the experiment. Changes in glucose and insulin were within the target range for treatment of the fatty liver syndrome or primary ketosis. Significant (P < 0.05) increases in the number of circulating white blood cells were observed in treated cows on the second day following treatment which was exclusively caused by an increase in the number of circulating neutrophils. Lymphocyte blastogenesis in response to ConA and the percentages of lymphocytes positive for CD2, CD4, CD8, CD49d and CD18 as well as the intensity of CD49d expression did not differ between the treatment and control groups. There was, however, a significant reduction (P < 0.01) in the intensity of CD18 expression on lymphocytes in the treated animals on the fourth day after treatment. In conclusion, a single administration of dexamethasone-21-isonicotinate in a dosage of 0.02 mg/kg i.m. at two weeks post partum in healthy cows had a significant but highly transient effect on CD18 expression on lymphocytes and the number of peripheral blood neutrophils, but did not affect lymphocyte blastogenesis or lymphocyte subpopulation patterns in peripheral blood.

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Section: Discussioncontrasting

confidence: 67%

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

et al. 2004

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“…Baypamune ® activates NK (natural killer) cells, stimulates lymphocytic proliferation, and activates macrophages and production of interleukins and antiviral interferon. Baypamune ® is suitable for modulation of non-specifi c immunity reaction and to stimulate suppressed immunity after the end of administration of immunosuppressive doses of steroids (Winnicka et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Therapy of Canine Deep Pyoderma with Cephalexins and Immunomodulators

Špruček¹,

Svoboda

Toman

et al. 2007

Acta Vet. Brno

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Pyodermas are among bacterial skin diseases often resisting antibiotic therapy. We therefore examined how the dogs with deep pyoderma (n = 29) respond to therapeutic effect of antibiotic cephalexins (Ceporex ® , 30 mg·kg -1 p.o., once a day for 9 -11 weeks) combined with immunomodulators (Baypamune ® , once a week i.m. pro toto). The dogs with the fi rst occurrence of pyoderma (n = 11) were treated by antibiotics alone, whereas the dogs with recurrent pyoderma (n = 18) were treated by either antibiotics alone (n = 8) or antibiotics combined with Baypamune ® (n = 10). Of 11 dogs with the fi rst occurrence of disease, 8 (73%) were successfully cured. However, only 5 of them (45%) stayed recovered after a period of two months that elapsed from the completion of therapy. Of the 8 dogs with recurrent pyoderma treated by antibiotics only, 6 (75%) recovered quickly but only 3 of them (38%) stayed healthy after 2 months elapsing from the therapy termination. Of the 10 dogs treated by antibiotics combined with immunomodulators, 8 (80%) regained health within a therapeutic period and 7 of them (70%) remained completely cured after 2 months from completion of therapy. The durations of treatment in dogs with the fi rst occurrence of pyoderma and those with recurrent pyoderma were 8.4 and 10.5 weeks, respectively, the difference begin signifi cant. Hair lenght and percentage of the skin area affected had no effect on the therapy duration. The disappearance of pruritus preceded the successful treatment. The results suggest that the joint treatment of deep pyodermas in dogs by antibiotics and immunomodulators may be superior to the purely antibiotic therapy, because of a stronger suppressive effect on the disease relapse. Cephalexin, Baypamune®

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Effects of inactivated parapoxvirus ovis on cellular and humoral events of the innate immune response in mice

Anziliero

Kreutz

Flores

et al. 2014

Cellular Immunology

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Effect of Baypamun® on Blood Leucocytes in Normal and Dexamathasone Treated Goats

Cited by 7 publications

References 18 publications

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

Therapy of Canine Deep Pyoderma with Cephalexins and Immunomodulators

Effects of inactivated parapoxvirus ovis on cellular and humoral events of the innate immune response in mice

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