Effect of Bauhinia variegata on Complete Freund`s Adjuvant Induced Arthritis in Rats

Balasubramanian, Ravikumar; Ravichandran, V.; Gobinath, M.; Anbu, J.; Harikrishnan, N.; Sumithra, M.; Sankari, M.; Venugopal, Rajan Babu; Sakthisekaran, Dhanapal

doi:10.3923/jpt.2007.465.472

Cited by 13 publications

(6 citation statements)

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“…Extra-articular complications of RA includes weight loss, oxidative tissue damage, chronic fatigue, and hematological disorders which are associated with the swelling around the joint, pain, abnormal increase in number of synovial cells, morphological changes, and pannus formation [3]. This chronic progressive autoimmune disorder of unknown cause is characterized by pain, swelling and stiffness of synovial joints [4]. The disease affected approximately about 0.75% in India and 1% adult population in the world and the responsible causative factors for the development of it are unknown [5].…”

Section: Introductionmentioning

confidence: 99%

Amelioration of oxidative and inflammatory changes by Peganum harmala seeds in experimental arthritis

Singhai

Patil

2021

Clin Phytosci

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Background The present study was designed to investigate the therapeutic effects against oxidative stress and alleviative effects of Peganum harmala seeds (PH) in rats with Complete Freund’s Adjuvant (CFA) induced arthritis. Methods The extract was evaluated for its phytoconstituents, antiarthritic and antioxidant properties. The action of chloroform (PHC) and ethanolic (PHE) extracts of PH was evaluated in adult Lewis rats (150-200 g).with CFA induced arthritis. Arthritic rats received PH extracts 100 mg/kg orally for 28 consecutive days (Prophylactic treatment) and from 14th day of CFA injection (Therapeutic treatment). Results PHE significantly suppressed the arthritis severity in rats than PHC in 28 days. All complications shown significant reduction (p< 0.05) in arthritic rats including paw volume (63.09%), body weight loss, decreased locomotor activity, erythrocyte sedimentation rate and synovial/hepatic tissues lipid peroxidation and increase in cellular antioxidants superoxide dismutase (U/mg) activities and hemoglobin counts. The results showed the presence of alkaloids and flavonoids in PHE. Histology and radiographic analysis of arthritic ankle joints indicated abnormal changes. Marked reduction in inflammation and arthritic changes were observed after treatment with PHE. Conclusion Therefore, the investigation suggests that PHE at 100 mg/kg will be useful in the management of rheumatoid arthritis complications which may possibly be due to boosting the intracellular antioxidant defense.

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Section: Introductionmentioning

confidence: 99%

Amelioration of oxidative and inflammatory changes by Peganum harmala seeds in experimental arthritis

Singhai

Patil

2021

Clin Phytosci

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“…It is also reported as an antihyperlipidemic remedy and, therefore, is valuable for obese persons. 9,11 Previous reports have reported antitumor, 9,10 antibacterial, 11 chemoprotective, cytotoxic, 12 anti-inflammatory, 13 antifungal, 14 antiarthritic, 15 antidiabetic, 16 and hepatoprotective 17 activities. Prunin is a flavanone glycoside with antioxidant, 18 anti-inflammatory, 19 deoxyribonucleic acid-binding affinity, 20 antiviral, 21 hypocholesterolemic, 22 and cardioprotective effects.…”

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confidence: 99%

Isolation of Prunin FromBauhinia variegataand Its Antioxidant Activity in Rats Fed an Atherogenic Diet

Zhang

2020

Natural Product Communications

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Atherosclerosis is no longer a disease attributed mainly to high cholesterol content in the body; it has come to be regarded as a chronic inflammatory disease with an autoimmune component. The purpose of this study was to investigate the effect of the prunin fraction (PF) isolated from the ethanolic extract of Bauhinia variegata against the release of various proinflammatory mediators in rats fed an atherogenic diet. The diet was administered orally to Sprague Dawley rats for 60 days to induce atherosclerosis. The blood serum of the rats was used to estimate the levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), thiobarbituric acid reactive substance, catalase, total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein using assay kits. Other physical parameters, such as body weight, feed intake, and systolic blood pressure, were also determined during the study. The results showed a significant protective effect of the PF against diet-induced atherosclerosis by decreasing the levels of proinflammatory mediators such as TNF-α and IL-6. Rats treated with PF (20 and 40 mg/kg) showed a change in systolic blood pressure and a reduction in oxidative stress induced by the atherogenic diet. Reduction in body weight and modulation of food intake were observed in PF-treated rats, which indicated atheroprotective, hypolipidemic, and antioxidant effects. The study concludes that the atheroprotective properties of PF are due to effects on the initial phase of plaque formation to thrombus formation. This study may help researchers to find a better alternative for selecting optimal therapies and preventing plaque formation. Future Significance: This article focuses on the molecular mechanisms involved in the evolution of atherosclerotic plaques and different targets that act at the starting stage of the plaque to thrombus formation. This may pave the way for selecting optimal therapies and preventing plaque complications.

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“…Around the world, arthritis affects one in five elderly people [ 19 ]. NSAIDs, sulfasalazine, D-penicillamine, cyclophosphamide, cyclosporine, methotrexate, azathioprine, glucocorticoids, anakinra, etanercept, abatacept, and infliximab, among others, have been used to treat arthritis [ 20 – 22 ]. But there are some risks, such as gastrointestinal ulcers, stomatitis, problems with the heart and blood vessels, pulmonary toxicity, myelosuppression, hematologic nephrotoxicity, hepatic fibrosis, cirrhosis, diarrhea, and local reactions at the injection site [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro Antimicrobial, Cytotoxic, Thrombolytic, and Antiarthritic Property of Different Parts of Bari Orchid

Rahaman,

Hasnine

et al. 2024

Evidence-Based Complementary and Alternative Medicine

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Many different herbal extracts have historically been utilized to treat microbe-induced infections, injuries, cancer, thrombosis, and arthritis. The purpose of this study was to determine the antibacterial, cytotoxic, in vitro thrombolytic, and in vitro antiarthritic properties of ethanolic extracts of stem and seed of Bari orchid 1 (BO) plant. This orchid plant was developed by the Bangladesh Agriculture Research Institute (BARI) in Gazipur. Fourteen microbes were employed in the antimicrobial investigation, and samples of orchids were compared to ciprofloxacin as a reference. The BO/seed extract was found to possess more antibacterial activity. The lethality test of brine shrimps was used to assess the LC50 values. The BO/stem extract exhibited a higher cytotoxicity potential, in comparison to the BO/seed extract. Two concentrations (1000 and 100 ppm) and two incubation times (24 hours and 1.5 hours) were used to assess the thrombolytic activity of the extracts. Regarding the thrombolytic effect, the BO/stem extract has demonstrated greater promise. Furthermore, the herbal extract’s antiarthritic activity was investigated at four different concentrations, and the results were evaluated in comparison with those of diclofenac sodium. When comparing BO/stem extract to other extracts, the greatest values for protein denaturation were obtained.

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Effect of Bauhinia variegata on Complete Freund`s Adjuvant Induced Arthritis in Rats

Cited by 13 publications

References 1 publication

Amelioration of oxidative and inflammatory changes by Peganum harmala seeds in experimental arthritis

Amelioration of oxidative and inflammatory changes by Peganum harmala seeds in experimental arthritis

Isolation of Prunin FromBauhinia variegataand Its Antioxidant Activity in Rats Fed an Atherogenic Diet

Evaluation of In Vitro Antimicrobial, Cytotoxic, Thrombolytic, and Antiarthritic Property of Different Parts of Bari Orchid

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