Effect of Basic Fibroblast Growth Factor on Fibrovascular Ingrowth into Porous Polyethylene Anophthalmic Socket Implants

Park, Won Chan; Han, Soo Kyung; Kim, Namju; Chung, Tae Young; Khwarg, Sang In

doi:10.3341/kjo.2005.19.1.1

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…Many studies have demonstrated that fibrovascular tissue ingrowth ocuurs from adjacent tissue into the porous PE from the periphery area toward the center of the implant. [9][10][11] However, the ophthalmologists find that PE implants are hard to suture and sometimes causes the suture needle to bend. Full impregnation of antibiotic solution into the implants, which is generally done to prevent infection, also takes a long time to achieve.…”

Section: Introductionmentioning

confidence: 99%

Preparation and comparative study of a new porous polyethylene ocular implant using powder printing technology

Suwanprateeb

Suvannapruk

Wasoontararat

et al. 2011

Journal of Bioactive and Compatible Polymers

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In this study, polyethylene (PE) was fabricated with porosity greater than 60% and 140-830 mm pore sizes which is suitable for fibrovascularization. The process involved three-dimensional printing of PE particles with water soluble adhesive powders followed by two-stepped heat treatment at 145 C with binder leaching between steps. Spherical ocular implants were fabricated by this process that had pore size, shaping and suturing ability comparable to commercially available porous PE (Medpor Õ ), but had lower density, higher porosity, and antibiotic uptake, as well as, more uniform pore interconnectivity and lower needle exertion force for suturing.

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Section: Introductionmentioning

confidence: 99%

Preparation and comparative study of a new porous polyethylene ocular implant using powder printing technology

Suwanprateeb

Suvannapruk

Wasoontararat

et al. 2011

Journal of Bioactive and Compatible Polymers

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“…Park et al concluded that bFGF soaked or injected PP implants have low risk of implant exposure from delayed biointegration. 31 Wound healing is a complex process and many different types of growth hormones play a role in different phases of it. 32,33 A single type of growth hormones may play a positive role in the biointegration of PP, but fibrovascularization needs more than 1 growth hormone and cellular interactions.…”

Section: Discussionmentioning

confidence: 99%

Effect of Allogeneic Platelet Lysate and Cyanoacrylate Tissue Glue on the Fibrovascularization of the Porous Polyethylene Implant

Öztürk

Şahi̇n

Tas

et al. 2016

Journal of Craniofacial Surgery

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Because of limited autogenous tissue sources, donor site morbidity, and difficulty of shaping the autologous tissue, surgeons often need to use alloplastic frameworks in reconstruction of 3-dimensional tissue defects. Synthetic porous polyethylene (PP) implant is widely used in plastic surgery for 3-dimensional reconstruction of the lost or highly deformed tissues. One of the main factors of PP implant exposure is delayed fibrovascular ingrowth. In the present study, the authors investigated the effect allogeneic plateletlysate (PL) and cyanoacrylate tissue glue (CTG) (2-octyl cyanoacrylate) on the fibrovascularization of the PP implant.Twenty adult female Wistar rats were divided into 4 groups equally, according to the different surgical techniques and implanted materials used. Only PP implant was implanted subcutaneously through a skin incision on the chest wall skin of the rats in the control group; however, CTG was applied with PP implant in the cyanoacrylate group, PL was applied with PP implant in the platelet group, CTG and platelet was applied together with PP implant in the combination group. All of the implants in each group were histologically assessed at postoperative second week. Determination of the collagen density in the tissues, inflammation, and necrosis and vascularization status was assessed semiquantitatively.A denser collagen structure, low inflammation, and necrosis were found in PL groups. There was, however, a significant decrease in vascular density with PL-treated groups. PL treatment may have a potential to reduce complications related to PP implants.

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“…It is also known as a potential mediator of intraocular angiogenesis. Park et al [26] reported that the fibrovascular ingrowth rate is higher in bFGF-treated porous polyethylene implants. In this study, bFGF staining was performed to identify the implant that yielded the strongest bFGF expression.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Alloplast Materials in Experimental Extraocular Muscle Surgery

Uğurbaş¹,

Koçer²,

Oto³

et al. 2010

Ophthalmic Res

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Background: Extraocular muscles may be recessed using implants as spacer material. Silicone retinal band is an example of a spacer used to elongate the superior oblique (SO) tendon in Brown’s syndrome and SO overaction; however, complications such as extrusion, scarring and restriction due to the implant have been reported. The purpose of our study was to evaluate and compare fibroblastic and inflammatory reactions to different alloplast materials in a rabbit model. Method: Twenty-three rabbit eyes underwent superior rectus (SR) expander surgery, and 9 eyes SR recession surgery. SR expander surgery was performed using either silicone retinal band (240 style; 6 eyes), polytetrafluoroethylene (Gore-Tex; 10 eyes) or porous polyethylene (Medpor; 7 eyes). Twenty eyes were enucleated at 4 weeks and 12 eyes at 8 weeks and examined by light microscopy. The expression of basic fibroblast growth factor (bFGF) was evaluated by immunohistochemical analysis. Results: All alloplast materials induced more inflammatory response compared to control eyes (p < 0.05). Medpor induced a markedly stronger inflammatory response than silicone and Gore-Tex (p < 0.05). Gore-Tex and silicone induced similar inflammatory responses. Gore-Tex implants yielded a slightly higher bFGF expression than silicone or Medpor implants (p = 0.07). Conclusion: Polytetrafluoroethylene (Gore-Tex) was found to be similar to silicone in its biocompatibility when used as spacer material in extraocular muscle tendon expander surgery. The high bFGF expression observed in Gore-Tex-implanted eyes suggests porous polymers may promote tissue ingrowth into the implant.

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Effect of Basic Fibroblast Growth Factor on Fibrovascular Ingrowth into Porous Polyethylene Anophthalmic Socket Implants

Cited by 12 publications

References 28 publications

Preparation and comparative study of a new porous polyethylene ocular implant using powder printing technology

Preparation and comparative study of a new porous polyethylene ocular implant using powder printing technology

Effect of Allogeneic Platelet Lysate and Cyanoacrylate Tissue Glue on the Fibrovascularization of the Porous Polyethylene Implant

Comparison of Alloplast Materials in Experimental Extraocular Muscle Surgery

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