Effect of Bang® Pre-Workout Master Blaster® combined with four weeks of resistance training on lean body mass, maximal strength, mircoRNA expression, and serum IGF-1 in men: a randomized, double-blind, placebo-controlled trial

Abstract

BackgroundThe aim of the current study was to determine if 4 weeks of consumption of Bang® Pre-Workout Master Blaster® (BMB; Vital Pharmaceuticals Inc., Weston, FL) combined with resistance training resulted in greater increases in muscle mass and maximal strength compared with resistance training combined with placebo (PLA). Additionally, we aimed to determine if BMB ingestion combined with resistance training preferentially altered resting skeletal muscle expression of microRNAs (miRs) or resting serum insulin-like growth factor (IGF-1).MethodsSixteen recreationally-active men completed the study. The study employed a block-randomized, double-blind, placebo-controlled, parallel design. Participants completed two testing sessions separated by 4 weeks of resistance exercise combined with daily supplementation of BMB or PLA. At each testing session, hemodynamics, body composition, and muscle and blood samples were obtained followed by strength assessments of the lower- and upper-body via measurement of squat and bench press one-repetition maximum (1-RM), respectively. A separate general linear model was utilized for analysis of each variable to determine the effect of each supplement (between-factor) over time (within-factor) using an a priori probability level of ≤0.05.ResultsNo significant effects were observed for dietary intake, hemodynamics, fat mass, body fat percentage, or serum IGF-1. A greater increase in total body mass (3.19 kg, 95% CI, 1.98 kg, 4.40 kg vs. 0.44 kg, 95% CI, − 0.50 kg, 1.39 kg) and lean body mass (3.15 kg, 95% CI, 1.80 kg, 4.49 kg vs. 0.89 kg, 95% CI, − 0.14 kg, 1.93 kg) was observed for the BMB group compared with PLA (p < 0.01). A significant increase over time was observed for miR-23a (p = 0.02) and miR-23b (p = 0.05) expression. A greater increase in squat 1-RM was observed for the BMB group (23.86 kg, 95% CI, 16.75 kg, 30.97 kg) compared with the PLA group (14.20 kg, 95% CI, 7.04 kg, 21.37 kg, p = 0.04).ConclusionsBMB supplementation combined with resistance exercise training for 4 weeks resulted in superior adaptations in maximal strength and LBM compared with resistance training with a placebo. No adverse resting hemodynamic or clinical blood safety markers were observed as a result of BMB supplementation. The superior outcomes associated with BMB supplementation could not be explained by resting serum IGF-1 or the skeletal muscle miRs measured, although resting miR-23a and miR-23b expression both increased as a result of resistance training.

Effect of L-citrulline, L-leucine, and multicomponent exercises on body compositions, physical activity, and amino acid concentrations in older Japanese women with low body mass index: A randomized double-blind placebo-controlled study

“…In another study, supplement intake (6 g CIT maleate, 5 g creatine, 3 g LEU, 3 g isoleucine, 1.5 g valine, etc.) and resistance exercise practice for 4 weeks significantly increased body mass and lean body mass compared with the placebo group (digestionresistant maltodextrin) [40]. The participants of the previous study were recreationally active men, whereas our study focused on older women with low BMI, but the effects of CIT and LEU intake and exercise practice were consistent.…”

Effects of Bang® Keto Coffee Energy Drink on Metabolism and Exercise Performance in Resistance-Trained Adults: A Randomized, Double-blind, Placebo-controlled, Crossover Study

“…Energy drinks and related caffeine-containing energy products are often consumed by the general population, adolescents, and individuals seeking to enhance exercise performance, augment training adaptations, and assist with weight loss [ 1 – 3 ]. These products typically contain caffeine and a blend of additional ingredients such as taurine, guarana, amino acids, and B-vitamins which are purported to improve energy levels, metabolism, and exercise performance [ 4 ].…”

Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults

“…Specifically, the purpose of this study was to examine the effect of four weeks of DYM supplementation with and without TCR on parameters of cardiovascular function and blood biomarkers associated with health. As methylliberine was never studied in humans, a four-week time period was selected based on previous studies on novel dietary supplements [28][29][30]. Based on previous findings [14,17,25], we hypothesized that DYM alone or with TCR would not produce significant abnormal changes in cardiovascular function parameters of heart rate, blood pressure, or electrical conduction of the heart assessed via an electrocardiogram, nor hematological markers of health for both men and women.…”