Effect of Balanites aegyptiaca on Ehrlich Ascitic carcinoma growth and metastasis in Swiss mice

Issa, Noha Mohey; Mansour, Fouad K.; El-Safti, Fatma A.; Nooh, Hanna Z.; Elsayed, Ibrahim

doi:10.1016/j.etp.2015.05.001

Cited by 10 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vivo saponin prolonged the survival time of mice bearing murine L1210 leukemia grafts exactly as vincristine [3], which is in good agreements with present finding where methanol fraction displayed remarkable in vitro cytotoxic effect against lymphoblastic leukemia (1301) cell line. Moreover, the current data illustrated powerful cytotoxicity of both Balanites extracts against liver carcinoma which is in conformity with reports recorded that Balanites suppressed Ehrlich ascetic tumors invaded/or affected mice liver and spleen [44]. Cytotoxic activity could also be related to quercetin glycosides present in the methanol extract.…”

Section: Discussionsupporting

confidence: 73%

Antidiabetic, cytotoxic, antioxidant and antitrematodal medicinal efficacy of polar and non-polar phytochemicals of Balanites aegyptiaca Del.

Al-Ashaal¹

2017

APJTD

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 73%

Antidiabetic, cytotoxic, antioxidant and antitrematodal medicinal efficacy of polar and non-polar phytochemicals of Balanites aegyptiaca Del.

Al-Ashaal¹

2017

APJTD

View full text Add to dashboard Cite

“…On the contrary to G1 and G3 animals, G2 (infected-BAF-EE-treated) and G4 (BAF-EEtreated only) goats revealed significant elevation in GPx activity which could be attributed to the BAF-EE antioxidant effect [9,71]. Antioxidant enzymes superoxide dismutase and catalase were elevated in mice treated with different parts of B. aegyptiaca extracts [72]. Phenolic and flavonoid contents of B. aegyptiaca were found to be responsible for its antioxidant effect [9,73].…”

Section: Discussionmentioning

confidence: 92%

Therapeutic Effect of Balanites Aegyptiaca Fruit’s Ethanol Extract in Egyptian Baladi Goats Experimentally Infected with Haemonchus Contortus: Blood Serum Biochemical, Oxidative Stress Markers and Pathological Studies

et al. 2020

View full text Add to dashboard Cite

the native breed of goats that is located in the Nile Delta and along the Nile Valley is known as Baladi goats. Amongst other breeds of goats, the Baladi goats have a great economic value [1] and play an essential role in the economy of small, marginal farmers and landless labourers in Egypt [2]. T HE THERAPEUTIC effect of Balanites aegyptiaca fruit's ethanolic extract (BAF-EE) in goats experimentally infected with Haemonchus contortus (H. contortus) was evaluated. Serum biochemical parameters, tissue oxidative stress status and pathological changes were investigated. Twelve goats were divided into 4 equal groups, G1 (infected-untreated), G2 (infected-BAF-EE treated), G3 (infected-albendazole treated) and G4 (uninfected-BAF-EE treated). Infection was conducted at 0-time, whereas treatment with BAF-EE and albendazole was given in the 5 th week post infection (PI). Blood samples were drawn on 0-time, 3 rd week PI and then biweekly till the 9 th week for serum biochemical analyses. At the end of experiment, all animals were slaughtered to estimate oxidative stress markers and histopathological alterations in the abomasal and hepatic tissues. Serum biochemistry of infected animals showed significant depression of total serum proteins, albumin, albumin/ globulin ratio, total antioxidant capacity and calcium levels. The activity of AST, ALT and γGT and the cholesterol, urea and creatinine levels were significantly elevated in the serum of infected animals. Glutathione peroxidase values decreased significantly in tissue homogenate of G1 and G3 goats than those in G2 and G4 goats. Malondialdehyde followed a reverse course. Abomasa of infected animals in G1 revealed inflammation, necrosis, petechial hemorrhages and cellular infiltration. Liver showed bile duct hyperplasia, degeneration of hepatocytes and cell infiltration. Intensity of alterations were lower in infected-treated animals. In conclusion, BAF-EE has hepatoprotective effect and can improve serum biochemical alterations and oxidative stress status in goats infected with H. contortus, justifying its use as a safe natural anthelmintic agent.

show abstract

“…(2017) ; Hassan et al. (2016) ; Saleh and Emara (2016) ; Issa et al. (2015) breast, lung, skin B. rufescens Garbi et al.…”

Section: Resultsmentioning

confidence: 99%

Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria

Malami

Jagaba

Abubakar

et al. 2020

Heliyon

View full text Add to dashboard Cite

This study was designed to explore and record various medicinal plants integrated into the traditional system of medicine for the treatment of cancer. The traditional system of medicine is a routine practiced among the indigenous ethnic groups of Sokoto state. A semi-structured questionnaire was designed and used for data collection around the selected Local Government Areas. A substantial number of plant species were identified, recorded, and collected for preservation. Data collected for each specie was analysed to assess its frequent use among the medicinal plants. A total of 67 species belonging to 31 families have been identified and recorded. Out of the 473 frequency of citation (FC), Acacia nilotica was the most frequently cited specie (32 FC, 64% FC, 0.6 RFC), followed by Guiera senegalensis (27 FC, 54% FC, 0.5 RFC), Erythrina sigmoidea (17 FC, 34% FC, 0.3 RFC), and subsequently Combretum camporum (15 FC, 30% FC, 0.3 RFC). The most common parts of the plants used include the barks (55.2%), the roots (53.2%), and the leaves (41.8%). Additionally, decoction (74.6%), powdered form (49.3%), and maceration (46.3%) are the most frequently used mode of preparation. The historical knowledge of a traditional system of medicine practiced by the native traditional healers of Sokoto for the treatment of cancer has been documented. The present study further provides a baseline for future pharmacological investigations into the beneficial effects of such medicinal plants for the treatment of cancer.

show abstract

Effect of Balanites aegyptiaca on Ehrlich Ascitic carcinoma growth and metastasis in Swiss mice

Cited by 10 publications

References 28 publications

Antidiabetic, cytotoxic, antioxidant and antitrematodal medicinal efficacy of polar and non-polar phytochemicals of Balanites aegyptiaca Del.

Antidiabetic, cytotoxic, antioxidant and antitrematodal medicinal efficacy of polar and non-polar phytochemicals of Balanites aegyptiaca Del.

Therapeutic Effect of Balanites Aegyptiaca Fruit’s Ethanol Extract in Egyptian Baladi Goats Experimentally Infected with Haemonchus Contortus: Blood Serum Biochemical, Oxidative Stress Markers and Pathological Studies

Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria

Contact Info

Product

Resources

About