Effect of BAL on Trichomonacidal Activity of Some Organic Arsenicals

(2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity

“…Actually, the compound 20 (LD 50 = 103 lmol/kg) was clearly less toxic than the corresponding As@O derivative, 4-arsenoso-phenylamine (25; LD 50 = 33 lmol/kg). This dithiarsolane ring permitted to stabilize the molecule since the As III atom in the As@O group exhibits a pronounced tendency to polymerization and oxidation [14].…”

Arsthinol nanosuspensions: pharmacokinetics and anti-leukaemic activity on NB4 promyelocytic leukaemia cells

“…The only arsenical currently formulated for human use in Western countries is melarsoprol, which is synthesized by complexing melarsen oxide with the metal‐chelating drug dimercaprol 2,3 . Administration of melarsoprol is indicated in the chemotherapy of the second stage of African trypanosomiasis.…”

Pharmacology and Biochemical Lesions

“…I am mentioning these points to indicate that although the main story is clear, there is still work required on the theoretical side, before we shall fully understand all the details involved in the action of arsenicals, and the influence of organic structure upon dissociability. It is worth mentioning also, in parenthesis, that an important practical application of the dissociability of mapharside-BAL is being made by Friedheim and colleagues [19] in New York. They find that these compounds readily kill some of the protozoa of disease (T. equiperdum), the BAL in this case acting as a carrier for the arsenic and is an antidote in reverse.…”