Effect of Bal (2, 3 Dimercaptopropanol) on Intraocular Copper*

Newell, Frank W.; Cooper, John A.; Farmer, Chester J.

doi:10.1016/s0002-9394(14)78369-2

Cited by 12 publications

(1 citation statement)

References 16 publications

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“…Muller (1931) and Habig, Lumen, and Snacken (1951) tried to convert copper into a harmless compound by the local or general application of sodium thiosulphate or sodium hyposulphite. Such attempts, as well as those making use of the property of BAL to form an insoluble compound with copper (Newell, Cooper, and Farmer, 1949), have been failures from the clinical point of view. The idea of introducing in the region of the foreign body an amalgam to which the latter would then attach itself firmly enough to be withdrawn (Wolflina, 1946) was no more successful than that of removing a non-magnetic foreign body by means of electro-magnetic forces (Endt and Ten Doesschate, 1949).…”

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Experimental Electrochemical Removal of Copper Splinters From the Isolated Vitreous

Krwawicz¹,

Zagórski²

1958

British Journal of Ophthalmology

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THE penetration of a splinter of copper or copper alloy into the eye always presents a serious problem. If the metal, especially in a relatively pure state, is left in the eye, it is bound to produce a heavy reaction in the form of acute iridocyclitis, violent uveitis, or vitreous abscess with all the sequelae of these conditions. Copper alloys containing less than 85 per cent. of copper usually cause a less severe reaction, but then chalcosis may develop, a condition which in most cases leads to a gradual loss of vision, although its course depends on the individual tolerance of the eye to the metal.The most reasonable though not the easiest course of action is to remove the copper splinter mechanically, using one of the methods devised for the removal of non-magnetic foreign bodies. These methods, though constantly being improved, are still far from perfect. Both the older instruments, such as the Desmarres-Luer forceps, and the more recent ones, such as the Holth forceps or the endoscopic appliances, may prove inadequate, and the only result of the operation will be a severe additional trauma. The risk is sometimes so grave that all idea of operative treatment must be abandoned.Some investigators have endeavoured to coat the splinter with a deposit of a neutral metal, such as gold, or to produce a magnetic alloy with iron (DukeElder, 1954). Muller (1931) and Habig, Lumen, and Snacken (1951) tried to convert copper into a harmless compound by the local or general application of sodium thiosulphate or sodium hyposulphite. Such attempts, as well as those making use of the property of BAL to form an insoluble compound with copper (Newell, Cooper, and Farmer, 1949), have been failures from the clinical point of view. The idea of introducing in the region of the foreign body an amalgam to which the latter would then attach itself firmly enough to be withdrawn (Wolflina, 1946) was no more successful than that of removing a non-magnetic foreign body by means of electro-magnetic forces (Endt and Ten Doesschate, 1949).Nevertheless, the idea of a non-instrumental method of removing a copper foreign body from the eye is so attractive that it should not be given up before all possibilities have been investigated.The purpose of our experiments was to examine the possibility of the *

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