Effect of baffles shape on the flow patterns and power consumption in stirred vessels

Foukrach, Mohammed; Ameur, Houari

doi:10.1007/s42452-019-1550-9

Cited by 18 publications

(5 citation statements)

References 26 publications

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“…Although the tangential velocity component dominated the flow in the vessel (results not shown), the impeller generated an axial outflow with trailing vortices interacting with the baffles and vessel wall, generating a recirculation loop in the region below the impeller. It is well‐established that baffling increases the turbulence level of any agitated vessels, promotes axial (top‐to‐bottom) recirculation, and thus reduces blend time (Foukrach & Ameur, 2019). However, the recirculation loop was found to be much weaker above the impeller, especially near the liquid surface, creating a region with significantly reduced fluid motion, which could be more difficult to homogenize especially in a full‐scale system.…”

Section: Resultsmentioning

confidence: 99%

Computational prediction of blend time in a large‐scale viral inactivation process for monoclonal antibodies biomanufacturing

Sirasitthichoke

Hoang

Phalak

et al. 2022

Biotech & Bioengineering

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Viral inactivation (VI) is a process widely used across the pharmaceutical industry to eliminate the cytotoxicity resulting from trace levels of viruses introduced by adventitious agents. This process requires adding Triton X‐100, a non‐ionic detergent solution, to the protein solution and allowing sufficient time for this agent to inactivate the viruses. Differences in process parameters associated with vessel designs, aeration rate, and many other physical attributes can introduce variability in the process, thus making predicting the required blending time to achieve the desired homogeneity of Triton X‐100 more critical and complex. In this study we utilized a CFD model based on the lattice Boltzmann method (LBM) to predict the blend time to homogenize a Triton X‐100 solution added during a typical full‐scale commercial VI process in a vessel equipped with an HE‐3‐impeller for different modalities of the Triton X‐100 addition (batch vs. continuous). Although direct experimental progress of the blending process was not possible because of GMP restrictions, the degree of homogeneity measured at the end of the process confirmed that Triton X‐100 was appropriately dispersed, as required, and as computationally predicted here. The results obtained in this study were used to support actual production at the biomanufacturing site.

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Section: Resultsmentioning

confidence: 99%

Computational prediction of blend time in a large‐scale viral inactivation process for monoclonal antibodies biomanufacturing

Sirasitthichoke

Hoang

Phalak

et al. 2022

Biotech & Bioengineering

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“…Sirasitthichoke et al studied the macromixing of several types of single baffle (beavertail, D-type, H-type, finger-type, and fin-type baffles) in a retreat-blade impeller (RBI) system through experiments and simulations, and found that the beavertail baffle had the smallest power number. Foukrach studied the influence of parameters such as the curvature of the baffle on the velocity, flow pattern, and power consumption, and found that compared with the straight baffle, the curved baffle can produce a strong radial jet when the mid-height of curved baffles was located at almost the same level of impeller blades. For a multiphase system, Karcz and Mackiewicz studied the influence of the number, length, and installation mode of baffles on the suspension characteristics of self-floating particles, and their results confirmed the superiority of nonstandard baffles.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Macromixing Performance of a Stirred Tank with a Novel V-Shaped Punched Baffle

Jia

Guo

et al. 2023

Ind. Eng. Chem. Res.

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A V-shaped punched baffle (VSPB) is developed to enhance fluid mixing in a stirred tank by producing impinging jet streams from face-to-face holes. Macromixing experiments and computational fluid dynamics (CFD) simulations are conducted with water and 0.5 wt % hydroxyethyl cellulose (HEC) solution as fluid to compare the performance of a standard baffle (SB), standard punched baffle (SPB) and VSPB. The experimental results show that the mixing time of VSPB is reduced by a maximum of 23 and 14.7% compared with those of SB and SPB at low speeds, respectively. With increasing stirring speed, the mixing time of all three baffles tends to be the same, but the power consumption of VSPB is less than that of SB and SPB with a Rushton turbine (RT). The simulation results show that the punched baffle can significantly increase the tangential velocity and turbulent kinetic energy of the fluid in the baffle region. Moreover, tiny vortices are at the back side of the punched baffles when the fluid is water. However, for a HEC solution, the flow field near the tank wall becomes disordered due to shear action caused by baffles and forms irregular vortices.

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“…Results showed that the most effective parameter on heat transfer is Reynolds number and baffle width and corner angle insignificant effect on Nusselt number. Foukrach and Ameur [18] studied the impact of the shape of the baffle on the flow characteristics numerically. The incompressible turbulent flow was simulated, and the optimum baffles were obtained.…”

Section: Introductionmentioning

confidence: 99%

Impact of inclined and perforated baffles on the laminar thermo-flow behavior in rectangular channels

2020

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In this paper, incompressible thermo-flow is simulated for a channel and with and without baffles. A baffle is connected to the channel from different angles. The effect of perforated inclined baffles on the flow pattern and heat transfer in a channel investigated. The computations are based on the finite element method, Galerkin scheme, and Newton-Raphson iterative method have been implemented. The flow regime was assumed to be laminar. Results show that the use of perforated baffles leads to an increase in the Nusselt number and minimized friction factor in comparison to the plain ones. The numerical results are compared with the available solutions in the literature. The defined efficiency of the baffle is obtained for various baffle types, baffle's angle, Reynolds number, and baffle's ratios. The optimum angle of the baffle inclinations was obtained. It was found that perforated baffles demonstrate show superior performance when compared with plain counterparts. Also, there is local heat transfer enhancement at the downstream of the stepped baffle caused by the impinging effect of flow, which is even more significant when baffle height becomes higher or the Reynolds number elevates. Obtained results show that a 135° perforated baffle is a better choice as it enhances the heat transfer with a minimal friction factor.

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Effect of baffles shape on the flow patterns and power consumption in stirred vessels

Cited by 18 publications

References 26 publications

Computational prediction of blend time in a large‐scale viral inactivation process for monoclonal antibodies biomanufacturing

Computational prediction of blend time in a large‐scale viral inactivation process for monoclonal antibodies biomanufacturing

Enhancement of Macromixing Performance of a Stirred Tank with a Novel V-Shaped Punched Baffle

Impact of inclined and perforated baffles on the laminar thermo-flow behavior in rectangular channels

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