Effect of bacteriological status on pressure ulcer healing in patients with advanced cancer

Sopata, Maciej; Łuczak, Jacek; Ciupińska, Maria

doi:10.12968/jowc.2002.11.3.26678

Cited by 33 publications

(42 citation statements)

References 6 publications

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“…Staphylococcus is readily identified by culture in all types of leg ulcers (26)(27)(28). In normal C57Bl6/J mice, colonization and biofilm formation by either S. aureus or S. epidermidis impaired wound reepithelialization (29).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response

Grice

Snitkin

Yockey

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

195

168

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Diabetics frequently suffer from chronic, nonhealing wounds. Although bacterial colonization and/or infection are generally acknowledged to negatively impact wound healing, the precise relationship between the microbial community and impaired wound healing remains unclear. Because the host cutaneous defense response is proposed to play a key role in modulating microbial colonization, we longitudinally examined the diabetic wound microbiome in tandem with host tissue gene expression. By sequencing 16S ribosomal RNA genes, we show that a longitudinal selective shift in wound microbiota coincides with impaired healing in diabetic mice ( Lepr db/db ; db/db). We demonstrate a parallel shift in longitudinal gene expression that occurs in a cluster of genes related to the immune response. Further, we establish a correlation between relative abundance of Staphylococcus spp. and the expression of cutaneous defense response genes. Our data demonstrate that integrating two types of global datasets lends a better understanding to the dynamics governing host–microbe interactions.

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Section: Discussionmentioning

confidence: 99%

Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response

Grice

Snitkin

Yockey

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

195

168

View full text Add to dashboard Cite

show abstract

“…Prior studies evaluating the microbiology of pressure ulcers in the general population have identified S. aureus, S. epidermidis, P. mirabilis, and P. aeruginosa as common bacterial species identified from ulcers. [36][37][38] In an extensive clinical compilation of 2500 cases of chronic pressure ulcers in patients with SCI, El-Toraei et al Table 3 Wound characteristics among studies examining pressure ulcers in individuals with SCI from the 11 studies included in our review…”

Section: Discussionmentioning

confidence: 99%

Bacteriology of pressure ulcers in individuals with spinal cord injury: What we know and what we should know

Dana

Bauman

2014

The Journal of Spinal Cord Medicine

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Individuals with spinal cord injury (SCI) are at increased risk for the development of pressure ulcers. These chronic wounds are debilitating and contribute to prolonged hospitalization and worse medical outcome. However, the species of bacteria and the role that specific species may play in delaying the healing of chronic pressure ulcers in the SCI population has not been well characterized. This study will review the literature regarding what is known currently about the bacteriology of pressure ulcers in individuals with SCI. An electronic literature search of MEDLINE (1966 to February 2014) was performed. Eleven studies detailing bacterial cultures of pressure ulcers in the SCI population met inclusion criteria and were selected for review. Among these studies, bacterial cultures were often polymicrobial with both aerobic and anaerobic bacteria identified with culture techniques that varied significantly. The most common organisms identified in pressure ulcers were Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, and Enterococcus faecalis. In general, wounds were poorly characterized with minimal to no physical description and/or location provided. Our present understanding of factors that may alter the microbiome of pressure ulcers in individuals with SCI is quite rudimentary, at best. Well-designed studies are needed to assess appropriate wound culture technique, the impact of bacterial composition on wound healing, development of infection, and the optimum medical and surgical approaches to wound care.

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“…The predominant organisms isolated by culture are S. aureus, S. epidermidis, and Streptococcus spp. (Table 2) (Daltrey et al, 1981;Sopata et al, 2002;Heym et al, 2004). Other bacteria that consistently appear include Proteus mirabilis, P. aeruginosa, and Propionibacterium spp.…”

Section: Pressure Ulcersmentioning

confidence: 99%

Molecular Microbiology: New Dimensions for Cutaneous Biology and Wound Healing

Martin

Zenilman

Lazarus

2010

Journal of Investigative Dermatology

139

100

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The role of bacteria in the pathogenesis of chronic, nonhealing wounds is unclear. All wounds are colonized with bacteria, but differentiating colonizers from invading organisms is difficult, if not impossible, at the present time. Furthermore, robust new molecular genomic techniques have shown that only 1% of bacteria can be grown in culture; anaerobes are especially difficult to identify using standard culture methods. Recent studies utilizing microbial genomic methods have demonstrated that chronic wounds are host to a wide range of microorganisms. New techniques also show that microorganisms are capable of forming highly organized biofilms within the wound that differ dramatically in gene expression and phenotype from bacteria that are typically seen in planktonic conditions. The aim of this review is to present a concise description of infectious agents as defined by new molecular techniques and to summarize what is known about the microbiology of chronic wounds in order to relate them to the pathophysiology and therapy of chronic wounds.

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Effect of bacteriological status on pressure ulcer healing in patients with advanced cancer

Abstract: The bacteria did not cause any clinical signs of infection. Variations in the number and types of bacteria in individual wounds did not correlate to the grade of ulcer or the dressing used.

Cited by 33 publications

References 6 publications

Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response

Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response

Bacteriology of pressure ulcers in individuals with spinal cord injury: What we know and what we should know

Molecular Microbiology: New Dimensions for Cutaneous Biology and Wound Healing

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