Effect of Bacteria and Bacterial Products on Antibody Response

Muñoz, J.

doi:10.1016/s0065-2776(08)60712-9

Cited by 102 publications

(41 citation statements)

References 222 publications

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“…ICAM-1 expression was examined using a phycoerythrin (PE)-labeled mouse anti-human mAb against ICAM-1 (HA58). FITC-labeled IgG 1 , (MOPC-21) and PE-labeled IgG 2b , (27)(28)(29)(30)(31)(32)(33)(34)(35) were used to control for specific staining.…”

Section: Surface Antigen Stainingmentioning

confidence: 99%

“…[22][23][24] Bacterial DNA has been known for its immunostimulatory activity for many years, 25,26 but the CpG-mediated mechanism responsible for this activity was unknown until recently. 5 Endotoxins in complete Freund's adjuvant contribute to its toxicity 27 which hamper its therapeutic use in humans in contrast to mice which are less sensitive to LPS.…”

Section: Introductionmentioning

confidence: 99%

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CpG DNA and LPS induce distinct patterns of activation in human monocytes

1999

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Section: Surface Antigen Stainingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CpG DNA and LPS induce distinct patterns of activation in human monocytes

1999

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“…The role of Adjuvant in the results is of interest. Munoz defines adjuvant as a substance that enhances antibody response to antigens injected simultaneously with it, or within a period of time closely spaced to the injection of antigen (22).…”

Section: Results Of These Experiments Have Shownmentioning

confidence: 99%

Plaque‐forming cell response in rats receiving mycobacterial adjuvant on day zero and SRBC on day four

Stanfield

Stephens

Clark

et al. 1971

Arthritis & Rheumatism

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Adjuvant disease was induced i n Holttman and Sprague-Dawley rats with intracutaneous tail injections of Mycobacterium butyricurn in oil on Day 0. Four days later, sheep red blood cells (SRBC) were administered intravenously. On Day 8, presence of specific antibody-producing cells from the excised spleens was demonstrated by the plaque-forming cell (PFC) technic. A total of 63 rats was studied in three separate plaquing experiments. There was an increase in PFC response in rats given M butyricum in oil over that observed in Control groups receiving SRBC only. Challenge with SRBC accelerated the onset and intensified subsequent joint inflammation in two of three experiments. Results were significant at the 95% confidence limit. These data support the suggestions of other investigators that adjuvant disease may

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“…The particularly strong potentiating effect of B. pertussis on the immunogenicity of injected protein antigens has been extensively studied (Munoz, 1964). However, little is known about the effect of bacterial adjuvants in respiratory immunization.…”

Section: Addition Of Bacterial Adjuvantsmentioning

confidence: 99%

Studies on respiratory immunization with tetanus toxoid: The role of adjuvants

Bartlema¹,

Braunius²,

Hölscher³

1972

Epidemiol. Infect.

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SUMMARYAerosol vaccination of mice with purified plain tetanus toxoid does not induce an immune response unless a suitable adjuvant is added.Aluminium phosphate is without effect by aerosol treatment. Killed cells of Klebsiella pneumoniae, although effective, are unsatisfactory owing to the long inhalation period needed.Killed Bordetella perussis cells were found to be an excellent adjuvant. A single aerosol treatment with a toxoid-B. pertussis mixture during a moderate exposure period evoked a considerable immune response. With repeated aerosol treatment of primed mice the addition of adjuvant is not required; booster treatment with plain toxoid is at least as effective.Extracts from B. pertussi8 cells exert as good an adjuvant effect as the wholecell vaccine. The remaining cell-wall debris also appears to be an active adjuvant.In combination with constant doses of adjuvant (108 B. pertussi8 cells), the 50 % protective doses (ED 50) of toxoid were determined by inhalation and by s.c. injection and were found to be 041875 and 0-0625 LFU respectively. This would imply that, as a result of the adjuvant action, the s.c. ED 50 is reduced by approximately a factor of 20; whereas the respiratory ED 50 is decreased by at least a factor of 100.It is suggested that the much more pronounced adjuvant activity in aerosol immunization is associated with the induction of strong cell-mediated hypersensitivity in the respiratory tract.

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Effect of Bacteria and Bacterial Products on Antibody Response

Cited by 102 publications

References 222 publications

CpG DNA and LPS induce distinct patterns of activation in human monocytes

CpG DNA and LPS induce distinct patterns of activation in human monocytes

Plaque‐forming cell response in rats receiving mycobacterial adjuvant on day zero and SRBC on day four

Studies on respiratory immunization with tetanus toxoid: The role of adjuvants

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