Effect of Azotemia Upon the Action of Intravenous Barbiturate Anesthesia

Dundee, John W.; Richards, R. K.

doi:10.1097/00000542-195407000-00001

Cited by 58 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depending on the elimination characteristics of the substance, decreased plasma protein binding may result in increased free plasma concentrations and, therefore, possibly in enhanced pharmacological effects (Gibson 1980). In addition, pharmacological sensitivity to drugs may be different in renal failure (Danhof et al 1984;Dundee & Richards 1954;Galeazzi et al 1979). For the calcium entry blocker nifedipine it has been shown that patients with chronic renal failure are more sensitive to the blood-pressurelowering effect than healthy control subjects (Kleinbloesem et al 1985).…”

mentioning

confidence: 99%

Influence of Renal Function on the Pharmacokinetics and Cardiovascular Effects of Nisoldipine After Single and Multiple Dosing

Harten¹,

Burggraaf²,

Brummelen³

et al. 1989

Clinical Pharmacokinetics

View full text Add to dashboard Cite

The pharmacokinetics and cardiovascular effects of the calcium entry blocker nisoldipine (10 mg twice daily) were studied in 6 patients with renal failure (creatinine clearance 23 +/- 9 ml/min) and 6 healthy control subjects after a single dose and 1 week of oral administration. No significant differences in elimination half-life, area under the concentration/time curve, peak plasma drug concentration and time to reach that peak were observed between renal patients and control subjects, and between single-dose and short term administration. The decrease in systolic blood pressure and increase in heart rate were similar in both groups, but the decrease in diastolic blood pressure was more pronounced in the patients. This can be explained by increased haemodynamic sensitivity for nisoldipine. Adverse effects were mainly restricted to the first day of administration.

show abstract

mentioning

confidence: 99%

Influence of Renal Function on the Pharmacokinetics and Cardiovascular Effects of Nisoldipine After Single and Multiple Dosing

Harten¹,

Burggraaf²,

Brummelen³

et al. 1989

Clinical Pharmacokinetics

View full text Add to dashboard Cite

show abstract

“…Delayed metabolism has been observed with certain drugs metabolized through the phase 1 enzymes: thiopental [8], azathioprine [9], clonidine [10], phenylbutazone [I I], cyclophosphamide [12], and phenothiazine and its deriva tives [13], These observations tend to confirm experimental results showing inhibition of the oxidative pathway by uremia in the experimental animal. On the other hand, delayed metabolism was also found with drugs metabolized through phase 2: sulfisoxazole [14], /^-aminosalicylate [15], sulfamethoxazole [16], a-methyldopa [17] and isoniazid [18,19].…”

Section: Metabolism O F Drugs In Uremic Manmentioning

confidence: 75%

“…[11] and Held and Enderle [31] for phenyl butazone [39], those of Dundee and Richards [8] and Reidenberg et al [28] for thiopental [40] and those of Scherrer et al [41] in their study on aminopyrine, as well as those of Fine and Sumner [42] on the acetylation of sulfadimidine. Studies conducted in hemodialyzed patients involve addi tional variations in the half-life of various molecules such as antipyrine, where this mechanism is not clearly under stood [43.…”

Section: Metabolism O F Drugs In Uremic Manmentioning

confidence: 99%

Uremia and the Liver. II. Drugs and the Liver in the Uremic Patient

Simon¹,

Meyrier²,

Brissot³

1981

Nephron

View full text Add to dashboard Cite

“…Another study showed that the frequency of side effects from prednisone was doubled when the serum albumin concentrations were below 2.5 g/100 ml (LEWIS et aI., 1971). Reduced binding of thiopental to plasma proteins may account for the much smaller total dose required to maintain anesthesia for prostatectomy in patients with azotemia (DUNDEE and RICHARDS, 1954). Significantly reduced binding of acidic drugs such as diphenylhydantoin and sulfonamides has been observed in patients with impaired renal function (.…”

Section: Plasma Protein Bindingmentioning

confidence: 99%

Concepts in Biochemical Pharmacology

Brodie¹,

Gillette²,

Ackerman³

1975

View full text Add to dashboard Cite

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to the publlsher, the amount of the fee to be determined by agreement with the publisher. © by Springer-Verlag Berlin· Heidelberg 1975. Softcover reprint of the hardcover ist edition 1975 Library of Congress Cataloging in Publication Data (Revised) Main entry under title: Concepts in biochemical pharmacology. Handbuch der experlmentellen Pharmakologie. Handbook of experimental pharmacology. New series, v. XXVIII, 1, etc. Includes bibliographies. I. Drug metabolism-Collected works.!. Argy, W. P. II. Brodie, B. B., ed. III. Gillette, James R., 1928-ed. IV. Ackerman, Helen S., ed. V. Series: Handbuch der experimentellen Pharmakologle, v. XXVIII, 1 QP905.H3 Bd. 28, t. 1, etc. [RM301] 615'. 7 79-135957 ISBN 0-387-05134-1. The use of general descriptive names, trade names, trade marks, etc. in this pUblication, even if the former are not especially Identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordlngiy be used freely by anyone. PrefacePart 3 of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man.Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmacokinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader.Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, enterohepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.The section on drug interactions opens with a chapter in which all drug interactions are viewed as result...

show abstract

Effect of Azotemia Upon the Action of Intravenous Barbiturate Anesthesia

Cited by 58 publications

References 0 publications

Influence of Renal Function on the Pharmacokinetics and Cardiovascular Effects of Nisoldipine After Single and Multiple Dosing

Influence of Renal Function on the Pharmacokinetics and Cardiovascular Effects of Nisoldipine After Single and Multiple Dosing

Uremia and the Liver. II. Drugs and the Liver in the Uremic Patient

Concepts in Biochemical Pharmacology

Contact Info

Product

Resources

About