Effect of autologous platelet rich plasma on anti-mullerian hormone and antral follicle count in sub fertile women with poor ovarian reserve

Banu, Jesmine; Ishrat, Shakeela; Sultana, Sabiha; Munira, Serajoom; Shume, Mehnaz Mustary; Huda, Sheikh Farhana

doi:10.18203/2320-1770.ijrcog20220033

Cited by 3 publications

(2 citation statements)

References 15 publications

(26 reference statements)

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“…AFC is a significant indicator of increased reproductive potential, and the significant improvement of AFC in the present study was similar to other studies. 17,35,36 Use of stem cells to prevent the degradation of follicles in the ovaries is not a recent process, but majority of related studies have mostly been clinical trails, and with animal hosts. [37][38][39] However, use of stem cells have also been observed in human trials as resisting DNA damage of natural aging to improve ovarian function.…”

Section: Discussionmentioning

confidence: 99%

Effects of autologous stem cell therapy for fertility enhancement among women with premature ovarian insufficiency

Banu

Jahan²,

Anwary

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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Background: Premature ovarian insufficiency (POI) is a condition where the ovary loses its normal reproductive potential earlier than 40 years, compromising fertility. There is no treatment for POI, only ovum or embryo donation. Autologous stem cell ovarian transplant (ASCOT) may be a procedure that creates new eggs in the ovaries of women with POI. The aim of the study was to find out the efficacy of ASCOT in patients suffering from POI. Methods: A total of 50 patients were included according to inclusion and exclusion criteria in this prospective observational study. POI was confirmed with low levels of anti-mullerian hormone (AMH) (<0.5 ng/dl), high level of follicle stimulating hormone (FSH) >25 ng/ml, and or a low number of antral follicle count (AFC) (<3 in each ovary). Results: Results showed that after stem cell therapy, mean AMH values increased by 0.48±0.306 and mean FSH values increased by 2.73±3.98 but the difference was not statistically significant. AFC values significantly decreased by 1.33±0.625 at 1st post-stem-cell cycle. During the second cycle, AMH and AFC increased by 0.110±0.051 and 4.63±1.49, respectively, and FSH decreased by 7.4±2.78. The increase in AMH and AFC was statistically significant, and the decrease in FSH was also statistically significant compared to baseline values. Conclusions: The study showed that autologous stem cell therapy can have a significant effect on women’s ovarian function and fertility. It showed that ASCOT can increase AMH and AFC, and decrease FSH in patients with POI, with a total pregnancy rate of 4% after the third cycle follow-up.

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Section: Discussionmentioning

confidence: 99%

Effects of autologous stem cell therapy for fertility enhancement among women with premature ovarian insufficiency

Banu

Jahan²,

Anwary

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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“…An observational study of these women revealed significant rise in AMH and fall in FSH over the next three months. 8 A one year follow up study of these women was undertaken to find out more clinically relevant outcomes like change in menstrual cycle and pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Ovarian function following intra-ovarian injection of platelet rich plasma in premature ovarian aging

Ishrat

Banu

Deeba

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Premature ovarian aging as evidenced by AMH levels less than 0.5 ng/ml is predictive of reduced success in management of infertility. The most effective treatment is in vitro fertilization which is not affordable or acceptable to most of our patients with low socioeconomic background. Intra-ovarian injection of autologous platelet rich plasma (PRP) improves the ovarian reserve markers but it remains to be seen whether it improves the pregnancy rate.Methods: This was a prospective study of 29 patients with poor ovarian reserve (age between 30-40 years, AMH<0.5 ng/ml), AFC<4 in both ovaries) who received intra ovarian injection of platelet rich plasma. The patients were followed up for one year and data was collected about clinically relevant outcomes like pregnancy.Results: Four women (13.8%) had pregnancy, of which 3 were spontaneous and one was following ovarian stimulation and intrauterine insemination. All had diagnosed clinical pregnancy, of which two women had live birth.Conclusions: Given the 13.8% rate of pregnancy within one year we can speculate that PRP injection may be a reasonable alternative to in vitro fertilization in women with diminished ovarian reserve.

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Efficacy of intraovarian autologous platelet-rich plasma administration in women with low ovarian reserve: A systematic review and meta-analysis

Sa’diah,

Dewanto,

Chandra

2024

Asian Pacific Journal of Reproduction

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Objective: To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma (PRP) on low ovarian reserve. Methods: A comprehensive search was performed utilizing pertinent search terms across electronic databases, including PubMed, Cochrane, and Google Scholar. We included studies that assigned infertile women with low ovarian reserve in experimental studies. Ovarian reserve parameters were measured before and after PRP injection into ovaries. The data of each study was retrieved and subsequently compiled. Results: Of 301 articles collected and reviewed, six studies were finally included in the meta-analysis. Following PRP injection, infertile women showed a non-significant increase in anti-Mullerian hormone (AMH) level (MD=0.10; 95% CI -0.04, 0.23), a significant increase in antral follicular count (AFC) (MD=1.88; 95% CI 0.47, 3.29), and a non-significant reduction in follicle-stimulating hormone (FSH) level (MD=-0.22; 95% CI -8.32, 7.87). Conclusions: Autologous PRP may increase AFC, but not AMH. Although it is found beneficial in enhancing ovarian reserve (AFC), further research with strong evidence is still required.

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Effect of autologous platelet rich plasma on anti-mullerian hormone and antral follicle count in sub fertile women with poor ovarian reserve

Cited by 3 publications

References 15 publications

Effects of autologous stem cell therapy for fertility enhancement among women with premature ovarian insufficiency

Effects of autologous stem cell therapy for fertility enhancement among women with premature ovarian insufficiency

Ovarian function following intra-ovarian injection of platelet rich plasma in premature ovarian aging

Efficacy of intraovarian autologous platelet-rich plasma administration in women with low ovarian reserve: A systematic review and meta-analysis

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