“…However, due to the different methods of production standardization is di cult and there is an open debate concerning the interpretation of the research on PRP [21,22]. In any case, the identi cation of PRP-derived anabolic growth factors (basic FGF, TGF-ÎČ1, TGF-ÎČ2, EGF, IGF-I, PDGF-AB, PDGF-BB, VEGF) and anti-in ammatory cytokines (IL-1ra, sTNF-R1, sTNF-RII, IL-4, IL-10, IL-13, IFNÎł) may present therapeutic potential in the treatment of osteoarthritis, especially in combination with MSCs, through enhancing or preserving their regenerative properties [23][24][25]. In addition, a positive effect on joint lubrication through stimulation of synoviocytes-derived hyaluronic acid has been reported for PRP, thus, when administered as co-adjuvant of MSCs, PRP could increase the intra-articular retention and survival of MSCs in an anti-in ammatory environment [26,27].…”