Effect of atropine on pancreatic response to HCl and secretin

Singer, Manfred V.; Solomon, Travis E.; Rammert, H.; Caspary, F.; Niebel, W.; Goebell, H.; Grossman, M. I.

doi:10.1152/ajpgi.1981.240.5.g376

Cited by 18 publications

(14 citation statements)

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“…The only available infor mation concerning the mutual influence of CCK and the parasympathetic nervous sys tem in the control of gallbladder motility has emerged from studies in vagotomized pa tients in whom it has been shown that gall bladder response to CCK is not diminished by vagotomy [20][21][22], The discrepancy could be explained by the fact that the remaining intrinsic postganglionic nerves of the gall bladder still release sufficient acetylcholine to allow a normal response to CCK, or by the existence of local cholinergic mechanisms, in dependent of the vagus nerve. In this context, it is of interest to point out that a similar sit uation occurs at the level of the pancreas, where atropine inhibits bicarbonate response to secretin [23], but vagotomy does not [24,25]. This inhibitory effect of atropine persists even after cutting the extrinsic nerves of the gland [26], suggesting the existence of an in trinsic cholinergic activity, maintained by the intrapancreatic ganglia.…”

Section: Discussionmentioning

confidence: 92%

Inhibitory Effect of Atropine on Cholecystokinin-Induced Gallbladder Contraction in Man

Gullo¹,

Bolondi²,

Priori³

et al. 1984

Digestion

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We have studied the effect of atropine on cholecystokinin (CCK)-induced gallbladder contraction in 7 healthy volunteers by means of real-time ultrasonography. Two series of tests were carried out in random order and on separate days. In one series of tests, CCK alone was infused for 4 successive 15-min periods at sequentially increasing doses of 0.0021, 0.0042, 0.0084, and 0.0168 Ivy dog units (IDU·kg^-1·min^-1. In the other series of tests, an infusion of a low dose of atropine, 5 μg·kg^-1 •h^-1, was added to the hormone infusion. The smallest dose of CCK which significantly contracted the gallbladder was 0.0042 IDU· kg^-1·mm^-1. The highest dose of CCK infused, 0.0168 IDU·kg^-1·min^-1, produced almost total contraction of the organ. In all subjects, the infusion of atropine completely blocked the gallbladder response to 0.0042 and 0.0084 IDU·kg^-1 •min^-1, and partially inhibited (by 52%) the response to the highest dose. In 2 subjects in whom a higher dose of atropine, 15 μg• kg^-1 •h^-1, was tested, gallbladder contraction was totally abolished, even when the largest dose of CCK was infused. Contrary to what is generally believed, the results indicate that the response of human gallbladder to CCK is largely dependent on cholinergic innervation.

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Section: Discussionmentioning

confidence: 92%

Inhibitory Effect of Atropine on Cholecystokinin-Induced Gallbladder Contraction in Man

Gullo¹,

Bolondi²,

Priori³

et al. 1984

Digestion

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“…5 and Table 1)). Maximal pancreatic secretion in response to secretin is not changed by atropine (Magee, Fragola & White, 1965; Singer, Solomon, Rammert, Caspary, Niebel, Goebell & Grossman, 1981) (Vaysse, Bastie, Pascal, Roux, Martinel, Lacroix & Ribet, 1975). It seems, therefore, that nerves control the sensitivity of the pancreas as a positive modulator of the secretin effect by changing the aparent Km and nH without changing the Vmax.…”

Section: Resultsmentioning

confidence: 99%

Characteristics of secretin‐stimulated pancreatic secretion in dogs.

Maggee¹,

Naruse²

1984

The Journal of Physiology

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SUMMARY1. The effect ofthe periodic interdigestive activity of the gut on secretin-stimulated pancreatic secretion was studied in eight conscious dogs each with a Thomas duodenal fistula, a gastric fistula and a Heidenhain pouch.2. Pancreatic water and bicarbonate responses to a small dose of secretin were greatly augmented in phase with the spontaneous periodic activity of the gut. This augmentation was closely related to pancreatic protein secretion.3. As the dose of secretin was increased the interval between peaks was prolonged, the peaks became less sharp, the nadirs were raised, and finally the periodic activity was no longer seen.4. Bilateral cervical vagal blockade with local anaesthetics reduced the secretinstimulated bicarbonate secretion by 50 % but the augmentation at the peak was not abolished. Atropine abolished the periodic augmentation completely and reduced the bicarbonate response by 80 %.5. The peak response of volume and bicarbonate to secretin obeyed MichaelisMenten kinetics. The nadir secretin dose response, however, was a sigmoid curve with a Hill coefficient larger than one. The action of atropine or hexamethonium was to shift the peak response kinetics to the nadir kinetics.6. It is concluded that the pancreatic response to secretin is greatly modulated by the spontaneous periodic activity of nerves.

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“…This has been made possible by the finding that this antagonist does not cross the meningeal barrier and therefore has no central action (Laduron & Lexsen, 1979 Singer et al (1981) have shown that basal cholinergic activity potentiated the effect of secretin on bicarbonate secretion. As atropine reduced the action of dopamine, as well as the action of secretin, it is probable that acetylcholine potentiates the effect of dopamine.…”

Section: Discussionmentioning

confidence: 99%

Action of dopamine on the exocrine pancreatic secretion of the intact dog

Delcenserie

Devaux

Sarles

1986

British J Pharmacology

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The effects of dopamine and domperidone, a dopamine antagonist, have been studied on the exocrine secretion of the dog pancreas. The purpose of this study was to see if dopamine acted on enzyme secretion and if its action was merely ‘pharmacological’ or had a physiological role. Conscious Beagle dogs, fitted with Thomas cannulae were studied following infusions of dopamine 125–1000 μg kg−1 h−1. During dopamine infusion, a secretory peak lasting 10 min was observed. This was followed by a stable plateau which was approximately 1/3 of the peak. The pattern of water, bicarbonate and protein secretion was similar. The maximum effect was obtained with 500 μg kg−1 h−1 dopamine. The stimulatory action of dopamine was blocked by domperidone, without any detected effect on the central nervous system, but not by propranolol or phenoxybenzamine. Domperidone 10 μg kg−1 almost completely suppressed the secretory response to the maximally effective dose of dopamine. This inhibition was not competitive. Atropine decreased the secretory response to dopamine. The protein response was not observed when dopamine was infused against a background infusion of secretin. This suggests that the effect of dopamine on protein secretion could be due to a wash‐out phenomenon. The maximally effective dose of domperidone, 10 μg kg−1, did not modify the pancreatic response to a solid meal. Thus, in the non‐anaesthetized dog, the effect of dopamine on water and bicarbonate secretion has been confirmed. It is concluded that dopamine had no detectable action on protein secretion and that the physiological role of dopamine with respect to pancreatic secretion is still questionable.

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Effect of atropine on pancreatic response to HCl and secretin

Cited by 18 publications

References 0 publications

Inhibitory Effect of Atropine on Cholecystokinin-Induced Gallbladder Contraction in Man

Inhibitory Effect of Atropine on Cholecystokinin-Induced Gallbladder Contraction in Man

Characteristics of secretin‐stimulated pancreatic secretion in dogs.

Action of dopamine on the exocrine pancreatic secretion of the intact dog

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