Effect of Atorvastatin on Regional Arterial Stiffness in Patients with Type 2 Diabetes Mellitus

Shinohara, K.; Shoji, Tetsuo; Kimoto, Eiji; Yokoyama, Hisayo; Fujiwara, Shigehiko; Hatsuda, Sawako; Maeno, Takaaki; Shoji, Takuhito; Fukumoto, Shinya; Emoto, Masanori; Koyama, Hidenori; Nishizawà, Yoshiki

doi:10.5551/jat.12.205

Cited by 75 publications

(58 citation statements)

References 32 publications

(29 reference statements)

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“…In our subjects treated with lipid-lowering medications (n 795), 648 patients were on statin treatment. PWV of the leg arteries, but not of the central arteries, showed a significant decrease during longitudinal observations with simvastatin 19) or atorvastatin 21) . Although the present finding was based on cross-sectional analysis, the observed inverse association between lipid-lowering medication and faPWV is in good agreement with longitudinal studies.…”

Section: Discussionmentioning

confidence: 98%

“…A very recent report by Tanaka et al 16) showed that baPWV and carotid-femoral PWV were closely and comparably associated with blood pressure, the Framingham risk score (FRS), and pre-existing CVD. Previous studies [17][18][19][20][21][22] showed that the impact of some CVD risk factors and medications on PWV varies among different arterial territories. Also, the association of pre-existing CVD with PWV appears to vary among these regional PWV measurements [23][24][25] ; therefore, it is an important question whether baPWV is an index of central or peripheral arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

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Brachial-ankle Pulse Wave Velocity as an Index of Central Arterial Stiffness

Tsuchikura

Shoji

Kimoto

et al. 2010

JAT

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142

116

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Aim: Stiffness of the central arteries plays an important role in the pathophysiology of cardiovascular disease, and pulse wave velocity (PWV) of the aorta has been used as the standard measure of central arterial stiffness. An automated device for brachial-ankle (ba) PWV is available, although information is limited whether baPWV reflects the stiffness of central or peripheral arteries. We therefore addressed this question in the present study. Methods: The subjects were 2,806 consecutive participants in our non-invasive vascular laboratory, excluding those with an ankle-brachial index (ABI) lower than 0.95. PWV measurements were simultaneously performed using an automated device for the ba, heart-femoral (hf, aorta), heart-carotid (hc), heart-brachial (hb), and femoral-ankle (fa) segments. Correlational analyses were performed (1) among these PWV values, (2) between PWV and individual risk factors, and (3)

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Brachial-ankle Pulse Wave Velocity as an Index of Central Arterial Stiffness

Tsuchikura

Shoji

Kimoto

et al. 2010

JAT

Self Cite

142

116

View full text Add to dashboard Cite

show abstract

“…In addition, clinical studies indicated that intervention with metformin, ACE inhibitors, angiotensin receptor blockers or alpha-lipoic acid would be able to reduce the levels of circulating ADMA [49][50][51][52][53][54][55] . The bibliography on the efficacy of statins on ADMA is contentious [20,[56][57][58][59][60][61] . Meanwhile, one clinical study demonstrated an ADMA decrease during intervention with rosiglitazone, and this was not recognized in a discrete age group [62,63] .…”

Section: Our Experience With Admamentioning

confidence: 99%

Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus

Konya

Miuchi

Satani

et al. 2015

WJEM

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Cardiovascular (CV) complications are an essential causal element of prospect in diabetes mellitus (DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine (ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM (T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin (U-Alb), mean intimal-medial thickness (IMT) and ankle brachial index (ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA (standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. Core tip: Asymmetric dimethylarginine (ADMA) is an emerging independent biomarker for prospective cardiovascular (CV) complications. In our study, the results show that the cases with a high level of ADMA could have diabetes mellitus CV (DMCV) complications in the future within five years. Furthermore, not only ADMA but also urinary albumin was associated with DMCV complications in the multiple regression analyses. The clinical acceptation of this parameter will rely on the availability of therapies to immediately reduce ADMA such as incretin-based drugs, which could support the part of ADMA as an etiologic risk factor.

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“…ABI was measured using a method described elsewhere [22][23][24] . Briefly, the patient remained still in the supine position for 5 minutes, and a cuff for blood pressure measurement was then applied to both arms and legs.…”

Section: Measurement Of Transcutaneous Oxygen Tension (Tcpo2) and Ankmentioning

confidence: 99%

Regions of Arterial Stenosis and Clinical Factors Determining Transcutaneous Oxygen Tension in Patients with Peripheral Arterial Disease

Ueno

Fukumoto

Koyama

et al. 2010

JAT

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Aims: Despite the clinical usefulness of transcutaneous oxygen tension (TcPO2) to assess the severity of limb ischemia, the factors determining TcPO2 in patients with peripheral arterial disease (PAD) have not been fully clarified. We therefore examined the regions of arterial stenosis and clinical factors affecting lower-extremity TcPO2. Methods: Resting TcPO2 (REST-TcPO2) and postexercise TcPO2 (Ex-TcPO2) in the calf region and the dorsalis pedis were measured simultaneously in 66 patients (132 limbs) with clinically suspected PAD, in whom angiography was also performed. Results: The peripheral arteries of the lower extremities were divided into five segments, and the impact of significant stenosis in each segment on ipsilateral TcPO2 was evaluated by multiple regression analysis. In the calf region, significant stenosis of the proximal arteries (common-external iliac artery) revealed stronger involvement determining Ex-TcPO2 than the peripheral segment (posterior tibial artery). In the dorsalis pedis, the peripheral segment (anterior tibial artery) more strongly determined Ex-TcPO2 and REST-TcPO2 than proximal segments. Age, creatinine, and diabetes were associated with REST-TcPO2 of the calf region independent of arterial stenoses, while those of the dorsalis pedis were independently associated with age, and creatinine. In contrast, Ex-TcPO2 in both regions was not independently associated with clinical factors, except for stenosis of the perfusing arteries. Conclusion: The vascular lesions affecting TcPO2 differ between the calf region (proximal peripheral) and the dorsalis pedis (proximal peripheral). In addition postexercise TcPO2 is solely determined by stenosis of the perfusing arteries, while TcPO2 at rest is affected by multiple clinical factors.J Atheroscler Thromb, 2010; 17:858-869.

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Effect of Atorvastatin on Regional Arterial Stiffness in Patients with Type 2 Diabetes Mellitus

Cited by 75 publications

References 32 publications

Brachial-ankle Pulse Wave Velocity as an Index of Central Arterial Stiffness

Brachial-ankle Pulse Wave Velocity as an Index of Central Arterial Stiffness

Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus

Regions of Arterial Stenosis and Clinical Factors Determining Transcutaneous Oxygen Tension in Patients with Peripheral Arterial Disease

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