Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease

Minami, Yoshitaka; Satoh, Mamoru; Maesawa, Chihaya; Takahashi, Yūji; Tabuchi, Tsuyoshi; Itoh, Tomonori; Nakamura, Motoyuki

doi:10.1111/j.1365-2362.2009.02110.x

Cited by 1,281 publications

(126 citation statements)

References 37 publications

(48 reference statements)

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“…In the same way, miR-221 and miR-222 were increased in endothelial progenitor cells from patients with coronary artery disease (CAD) and in those patients, 12 months of treatment with atorvastatin, but not with pravastatin, diminished the expression of miRs-221/222 20 . Those results are in agreement with the reduction of these miRs mediated by statins in our study.…”

Section: Discussionmentioning

confidence: 67%

Role of Micro-RNAs 221/222 on Statin Induced Nitric Oxide Release in Human Endothelial Cells

Fajardo¹

2013

J Pharmacogenomics Pharmacoproteomics

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Section: Discussionmentioning

confidence: 67%

Role of Micro-RNAs 221/222 on Statin Induced Nitric Oxide Release in Human Endothelial Cells

Fajardo¹

2013

J Pharmacogenomics Pharmacoproteomics

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“…Interestingly, a study from Minami et al, suggests the physiological role of miR-221/222 is closely linked to the proliferation of endothelial cells. It was shown that levels of miR-221/222 were significantly higher in the CAD group than in the non-CAD group and levels of miR-221/222 were weakly negatively correlated with Endothelial progenitor cells (EPCs) number in the CAD group (Minami et al, 2009). Collectively, these reports suggest miR-221/222 play an antiangiogenic role in vitro, although the in vivo functions are undetermined.…”

Section: Individual Mirnas In Endothelial Cell Biologymentioning

confidence: 67%

The role of blood flow and microRNAs in blood vessel development

Liu¹,

Krueger²,

Noble³

2011

Int. J. Dev. Biol.

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The circulatory system is the first organ system that develops during embryogenesis, and is essential for embryo viability and survival. Crucial for developing a functional vasculature are the specification of arterial-venous identity in vessels and the formation of a hierarchical branched vascular network. Sprouting angiogenesis, intussusception, and flow driven remodeling events collectively contribute to establishing the vascular architecture. At the molecular level, arterialvenous identity and branching are regulated by genetically hardwired mechanisms involving Notch, vascular endothelial growth factor and neural guidance molecule signaling pathways, modulated by hemodynamic factors. MicroRNAs are small, non-coding RNAs that act as silencers to fine-tune the gene expression profile. MicroRNAs are known to influence cell fate decisions, and microRNA expression can be controlled by blood flow, thus placing microRNAs potentially at the center of the genetic cascades regulating vascular differentiation. In the present review, we summarize current progress regarding microRNA functions in blood vessel development with an emphasis on studies performed in zebrafish and mouse models.

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“…A main role for miRNA-221/222 in endothelial therapeutic applications in humans has also been proposed [128]. In fact, recent work demonstrate that miRNA-221 is regulated by hyperglycemia in HUVEC cells, and lipid-lowering therapies (LLT) with atorvastatin increases EPC numbers and decreases miRNA-221/222 levels in patients with coronary artery disease [129,130].…”

Section: The Mirna 221mentioning

confidence: 99%

The admiR-able advances in cardiovascular biology through the zebrafish model system

Gays

Santoro

2012

Cell. Mol. Life Sci.

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MicroRNAs are small non-coding RNAs endogenously expressed by all tissues during development and adulthood. They regulate gene expression by controlling the stability of targeted messenger RNA. In cardiovascular tissues microRNAs play a role by modulating essential genes involved in heart and blood vessel development and homeostasis. The zebrafish (Danio rerio) system is a recognized vertebrate model system useful to study cardiovascular biology; recently, it has been used to investigate microRNA functions during natural and pathological states. In this review, we will illustrate the advantages of the zebrafish model in the study of microRNAs in heart and vascular cells, providing an update on recent discoveries using the zebrafish to identify new microRNAs and their targeted genes in cardiovascular tissues. Lastly, we will provide evidence that the zebrafish is an optimal model system to undercover new microRNA functions in vertebrates and to improve microRNA-based therapeutic approaches.Keywords MicroRNA Á Zebrafish Á Heart Á Blood vessel Á Development MiRNAs: function and mechanismMicroRNAs (e.g., miRs or miRNAs) are evolutionary conserved small non-coding RNAs, usually 21-25 nt long, that regulate gene expression at a post-transcriptional level.

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Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease

Abstract: This study demonstrates that LLT with atorvastatin increases EPC numbers and decreases miR-221/222 levels in patients with CAD, possibly contributing to the beneficial effects of LLT with atorvastatin in this disorder.

Cited by 1,281 publications

References 37 publications

Role of Micro-RNAs 221/222 on Statin Induced Nitric Oxide Release in Human Endothelial Cells

Role of Micro-RNAs 221/222 on Statin Induced Nitric Oxide Release in Human Endothelial Cells

The role of blood flow and microRNAs in blood vessel development

The admiR-able advances in cardiovascular biology through the zebrafish model system

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