Effect of atorvastatin on chronic periodontitis: a randomized pilot study

Fajardo, Martha Eugenia; Rocha, M.L. Márquez; Sánchez-Marín, Francisco J.; Espinosa-Chávez, Emanuel Jaime

doi:10.1111/j.1600-051x.2010.01619.x

Cited by 72 publications

(101 citation statements)

References 47 publications

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“…26 ATV and SMVhave been found to have osteoblastic actions in animal and human studies. 13-16 ,Fajardo et al 27 in a study found that ATV administration improved periodontal parameters, including PD, CAL and mobility over a 3-month period. Morris et al 28 showed effective IBD fill and a greater decrease in PD and RAL gain compared to the control group when injectable SMV was used in three-walled periodontal IBDs, class II furcations defects and edentulous alveolar ridges in beagle dogs.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial

Martande¹,

Kumari²,

Pradeep³

et al. 2017

J Dent Res Dent Clin Dent Prospects

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Background. Statins are the recently evolved agents that aid in periodontal regeneration and ultimately in attaining periodontal health. Atorvastatin (ATV) and Simvastatin (SMV) are specific competitive inhibitors of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. The current study was conducted to compare the effectiveness of 1.2% ATV and 1.2% SMV, in addition to scaling and root planing (SRP), in the treatment of intrabony defects in subjects with chronic periodontitis.Methods. Ninety-six individuals were categorized into three treatment groups: SRP plus 1.2% ATV, SRP plus 1.2% SMV and SRP plus placebo. Clinical parameters of full-mouth plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), and relative attachment level (RAL) were recorded at baseline before SRP and at 3, 6 and 9 months. Bone fill was assessed using percentage radiographic defect depth reduction at baseline, 6 months and 9 months.Results. Both ATV and SMV showed significant PD reduction and RAL gain than placebo. ATV group showed greater mean PD reduction and mean RAL gain as compared to SMV group at 3, 6 and 9 months. Furthermore, ATV group sites exhibited a significantly greater percentage of radiographic defect depth reduction (33.23 ± 3.11%; 34.84 ± 3.07%) as compared to SMV (30.39 ± 3.36%; 32.15 ± 3.37%) at 6 and 9 months.Conclusion. ATV resulted in greater improvements in clinical parameters with higher percentage of radiographic defect depth reduction as compared to SMV in the treatment of intrabony defects in CP subjects.

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Section: Discussionmentioning

confidence: 99%

Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial

Martande¹,

Kumari²,

Pradeep³

et al. 2017

J Dent Res Dent Clin Dent Prospects

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“…Statins could attenuate the inflammation-related systemic effects. Controlled clinical trials using systemically or locally administered statins have shown significant improvements of periodontal sequelae [33, 34]. …”

Section: Discussionmentioning

confidence: 99%

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

et al. 2011

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Common risk factors of periodontitis and cardiovascular diseases fuel the debate on interrelationships between them. The aim is to prove whether statins may influence periodontal parameters by affecting either of these factors. Out of the 4,290 subjects of SHIP (Study of Health in Pomerania), we included subjects aged >30 years (219 with statins, 2937 without) and excluded edentulous. We determined periodontal measures, cholesterol fractions, and inflammation markers. Statin use and periodontal risk factors were assessed. Gingival plaque and periodontal attachment loss were associated with systemic LDL cholesterol (P < 0.001) and C-reactive protein CRP (P = 0.019) revealing interaction with statin use. When adjusted for age, sex, smoking, diabetes, education, and dental service, statins were identified as effect modifiers abolishing the relationship between attachment loss and LDL and between gingival plaque and LDL (interactions P < 0.001). No statin-related interaction was detected with increase in CRP. The interaction supports the view of inter-relationships between periodontal and systemic inflammatory mediators.

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“…Recent studies reported a correlation between statin use and improvement of clinical signs of periodontal disease including bone defect, tooth movement, and tooth loss 15–17 . This prompted a hypothesis that statins might directly affect osteoclasts that are responsible for periodontal bone loss.…”

mentioning

confidence: 99%

Fluvastatin Inhibits Osteoclast Differentiation and Porphyromonas gingivalis Lipopolysaccharide‐Induced Alveolar Bone Erosion in Mice

Pokhrel

Kim

et al. 2017

Journal of Periodontology

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Effect of atorvastatin on chronic periodontitis: a randomized pilot study

Abstract: The results suggest that ATV might have beneficial effects on bone alveolar loss and tooth mobility in subjects with periodontal disease.

Cited by 72 publications

References 47 publications

Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial

Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

Fluvastatin Inhibits Osteoclast Differentiation and Porphyromonas gingivalis Lipopolysaccharide‐Induced Alveolar Bone Erosion in Mice

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