Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air–Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs)

Offer, Svenja; Hartner, Elena; Bucchianico, Sebastiano Di; Bisig, Christoph; Bauer, Stefanie; Pantzke, Jana; Zimmermann, Elias J.; Cao, Xin; Binder, Stefanie Petrou; Kuhn, Evelyn M.; Huber, Ambros; Jeong, Seongho; Käfer, Uwe; Martens, Patrick; Meščeriakovas, Arūnas; Bendl, J; Brejcha, Ramona; Buchholz, Angela; Gat, Daniella; Hohaus, Thorsten; Rastak, Narges; Jakobi, Gert; Kalberer, Markus; Kanashova, Tamara; Hu, Yue; Ogris, Christoph; Marsico, Annalisa; Theis, Fabian J.; Pardo, Michal; Gröger, Thomas; Oeder, Sebastian; Orasche, Jürgen; Paul, Andreas; Ziehm, Till; Zhang, Zhihui; Adam, Thomas; Sippula, Olli; Sklorz, Martin; Schnelle-Kreis, Jürgen; Czech, Hendryk; Kiendler‐Scharr, Astrid; Rudich, Yinon; Zimmermann, Ralf

doi:10.1289/ehp9413

Cited by 52 publications

(50 citation statements)

References 130 publications

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“…This mixture of SPs and NAP was then diluted with humidified air (moistened by a PermaPure humidifier FC125-240, Perma Pure, USA) in an ejector diluter (model VKL 10, Palas GmbH, Germany) before entering the OFR (PAM reactor 27,28 ) for the experimental simulation of atmospheric photooxidation (SOA formation and aging) by OH radicals. During aging, the low volatile SOA condensed onto the SP, resulting in predominantly internally mixed particles with organic coatings and SP cores (SOA NAP -SP) as was shown by transmission electron microscopy images in Offer et al 32 As we investigated 4 times lower concentrations in this study, some smaller particles (<50 nm) were produced, indicating the simultaneous occurrence of externally mixed particles. Differences in aged aerosol composition were experimentally assessed by varying the aging conditions in the PAM reactor, such as variations in relative humidity of either 40% or 70% and varying OH equivalent aging times (2−9 days).…”

Section: Methodssupporting

confidence: 57%

“…Experimental Setup for Aerosol Generation, Online Characterization, and Filter Sampling. The experimental setup has been previously described in detail by Offer et al 32 and Zhang et al 33 and is only briefly presented here. Elemental carbon (EC)-rich SPs with a geometric mean diameter of about 100 nm were produced by means of a miniature CAST soot generator (model 5201C, Jing Ltd., Switzerland).…”

Section: Methodsmentioning

confidence: 99%

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On the Complementarity and Informative Value of Different Electron Ionization Mass Spectrometric Techniques for the Chemical Analysis of Secondary Organic Aerosols

Hartner

Paul

Käfer

et al. 2022

ACS Earth Space Chem.

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The atmospheric aging of volatile organic compounds leads to the formation of complex mixtures of highly oxidized secondary organic aerosols (SOAs). State-of-the-art mass spectrometry (MS) has become a pivotal tool for their chemical characterization. In this study, we characterized the chemical complexity of naphthalene-derived SOA by three different time-of-flight (TOF) mass spectrometric techniques applying electron ionization: high-resolution–TOF–aerosol MS (AMS), direct inlet probe (DIP)–high-resolution TOFMS, and thermal desorptioncomprehensive two-dimensional gas chromatographyTOFMS (GC × GC). We discuss AMS as an online, DIP as an atline, and GC × GC as an offline technique to compare their informative value for studying the oxidation state, volatility, and molecular composition of laboratory-generated SOA. For GC × GC, the accessible organic content was limited to (semi-)volatile compounds and supported a reliable assignment of the molecular composition. DIP and AMS were used to derive secondary parameters such as O/C and H/C ratios, the general functionality of the compound classes and their abundance upon photochemical aging. Thereby, while the induced pyrolysis in the AMS extended the accessibility range to polar, high-molecular-weight compounds, thermal fragmentation also led to limited molecular information. For DIP, low-volatility compounds could be volatilized and the high mass resolution was useful to resolve isobaric mass fragments and assign reliable sum formulas of fragments and molecular ions. Although no single technique can provide information to describe the full chemical complexity of the SOA, AMS, DIP, and GC × GC in their complementarity are well suited to investigate the impact of SOA on health and environment.

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Section: Methodssupporting

confidence: 57%

Section: Methodsmentioning

confidence: 99%

On the Complementarity and Informative Value of Different Electron Ionization Mass Spectrometric Techniques for the Chemical Analysis of Secondary Organic Aerosols

Hartner

Paul

Käfer

et al. 2022

ACS Earth Space Chem.

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“…Chowdhury et al has reported increased oxidative stress responses and toxicity in cells exposed to aged aSOA compared to fresh aSOA , which could be explained by the higher carbon oxidation state found in aged aerosol . Recently, Offer et al corroborated this observation in an Air–Liquid Interface system . Meanwhile Han et al observed a stronger proteome-wide impact in cells exposed to fresh aSOA than aged aSOA, and Fushimi et al reported a weaker toxic potential from aged naphthalene-derived SOA .…”

Section: Pathogenic Impact Of Soamentioning

confidence: 98%

Pathogenic Mechanisms of Secondary Organic Aerosols

Déméautis

Delles

Tomaz

et al. 2022

Chem. Res. Toxicol.

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Air pollution represents a major health problem and an economic burden. In recent years, advances in air pollution research has allowed particle fractionation and identification of secondary organic aerosol (SOA). SOA is formed from either biogenic or anthropogenic emissions, through a mass transfer from the gaseous mass to the particulate phase in the atmosphere. They can have deleterious impact on health and the mortality of individuals with chronic inflammatory diseases. The pleiotropic effects of SOA could involve different and interconnected pathogenic mechanisms ranging from oxidative stress, inflammation, and immune system dysfunction. The purpose of this review is to present recent findings about SOA pathogenic roles and potential underlying mechanisms focusing on the lungs; the latter being the primary exposed organ to atmospheric pollutants.

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“…Offer et al [77] also used an air-liquid interface to assess lung cells' exposure to particles and demonstrated the importance of the chemical PM composition in adverse health outcomes [77]. This evidence is in line with the most recent articles in this field [76][77][78][79].…”

Section: Carbon Blackmentioning

confidence: 63%

“…Barosova et al [76] studied the impact of nanomaterials in 3D lung co-cultures, realising that acute or prolonged exposure to nanomaterials may induce different responses [76]. Offer et al [77] also used an air-liquid interface to assess lung cells' exposure to particles and demonstrated the importance of the chemical PM composition in adverse health outcomes [77]. This evidence is in line with the most recent articles in this field [76][77][78][79].…”

Section: Carbon Blackmentioning

confidence: 80%

Impact of Particles on Pulmonary Endothelial Cells

Almeida-Silva

Cardoso

Alemão

et al. 2022

Toxics

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According to the WHO, air quality affects around 40 million people, contributing to around 21,000 premature deaths per year. Severe respiratory diseases, such as asthma and chronic obstructive pulmonary disorder, can be promoted by air pollution, which has already been documented; this is one of the reasons why air quality is a very relevant factor for human health and well-being. Aerosols are an aggregation of solid or liquid particles dispersed in the air and can be found in the form of dust or fumes. Aerosols can be easily inhaled or absorbed by the skin, which can lead to adverse health effects according to their sizes that range from the nanometre to the millimetre scale. Based on the PRISMA methodology and using the Rayyan QCRI platform, it was possible to assess more than four hundred research articles. This systematic review study aimed to understand the impact of particles on pulmonary endothelial cells, namely particulate matter in different sizes, cigarette smoke, diesel exhaust particles and carbon black. The main conclusions were that particles induce multiple health effects on endothelial cells, namely endothelial dysfunction, which can lead to apoptosis and necrosis, and it may also cause necroptosis in lung structure.

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Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air–Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs)

Cited by 52 publications

References 130 publications

On the Complementarity and Informative Value of Different Electron Ionization Mass Spectrometric Techniques for the Chemical Analysis of Secondary Organic Aerosols

On the Complementarity and Informative Value of Different Electron Ionization Mass Spectrometric Techniques for the Chemical Analysis of Secondary Organic Aerosols

Pathogenic Mechanisms of Secondary Organic Aerosols

Impact of Particles on Pulmonary Endothelial Cells

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