Effect of Asymptomatic Plasmodium falciparum Parasitaemia on Platelets Thrombogenicity in Blood Donors

Aninagyei, Enoch; Adu, Patrick; Rufai, Tanko; Ampomah, Paulina; Kwakye-Nuako, Godwin; Egyir-Yawson, Alexander; Acheampong, Desmond Omane

doi:10.1007/s12288-020-01390-w

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…The median value of MPV was significantly lower in malaria-infected adult patients than in apparently healthy adults, in agreement with a study conducted in Ghana 32 but in contrast with studies conducted in Brazil, 15 Sudan, 33 and Uganda. 34 This inconsistency and variation in malaria infection can be explained by the fast splenic and medullary release of huge volumes of platelets in response to the increased demand for these cells.…”

Section: Discussionsupporting

confidence: 90%

“… 34 This inconsistency and variation in malaria infection can be explained by the fast splenic and medullary release of huge volumes of platelets in response to the increased demand for these cells. 35 The median value of PCT was significantly decreased in malaria-infected adult patients, which was corroborated with previous studies conducted in Thailand, 8 Ghana, 32 and Nigeria. 36 Low PCT in malaria may be due to the sensitization of platelets by parasitized red blood cells, resulting in increased platelet sensitivity to adenosine diphosphate (ADP) and better dense-granule secretion.…”

Section: Discussionsupporting

confidence: 82%

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Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

Asmerom

Gemechu

Bete

et al. 2023

JBM

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Background Malaria is a major public health problem with the highest morbidity and mortality in developing countries. Hematological changes play a great role in malaria pathogenesis through platelets and platelet parameters. However, the changes in platelet parameters are not clearly described in Ethiopia. Therefore, this study aimed to compare platelet parameters and their correlation with parasitemia among malaria-infected adult patients and healthy adults. Methods An institutional-based comparative cross-sectional study was conducted involving 186 (93 malaria-infected patients and 93 healthy adults) study participants using a convenient sampling technique at Jinella health center, Harar, Eastern Ethiopia, from July 10–August 10, 2022. Five milliliters of venous blood were collected from each study participant, and platelet parameters were analyzed using a Unicel (DxH 800) automated hematologic analyzer. A drop of blood was taken from malaria-suspected patients for blood film preparation. Results between two groups were compared using the Mann–Whitney U -test. Spearman’s rank correlation coefficient was used to evaluate the relationships between two continuous variables. A P-value of < 0.05 was considered statistically significant. Results Platelet, plateletcrit, and mean platelet volume of malaria-infected patients were significantly lower as compared with healthy adults (103 x10 3 cells/μL vs 268 x10 3 cells/μL, 0.13 fl vs 0.23 fl, and 9.6 fl vs 15.3 fl), respectively). Conversely, platelet distribution width and platelet large cell ratio were higher in malaria-infected patients than healthy adults (19.2% vs 15.3% and 0.35% vs 0.29%), respectively). Parasitemia levels had a moderately inverse correlation with platelet count (r= −0.419) and a weakly positive correlation with mean platelet volume (r=0.278). Conclusion The platelet, plateletcrit, and mean platelet volume of malaria-infected patients were significantly lower as compared with healthy adults. Malaria parasitemia had a moderate inverse correlation with platelet count and a weak positive correlation with mean platelet volume. Thrombocytopenia and alteration of platelet parameters should be considered in malaria patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 82%

Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

Asmerom

Gemechu

Bete

et al. 2023

JBM

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“…Furthermore, high TNF- α /IL-10 ratio has also been associated with anaemia due to malaria in an earlier study [ 32 ]. Additionally, the negative effect of malaria parasitemia on platelets thrombogenicity has also been reported [ 33 ]. This plethora of metabolically active biomolecules has been suggested to induce either early or delayed transfusion reaction, which are mostly unexplained [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

The Use of Screening Algorithm to Defer Blood Donors with Subclinical Malaria

Acheampong

Aninagyei

2021

Journal of Tropical Medicine

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Plasmodium falciparum infection in blood donors is common in malaria endemic countries, including Ghana. To date, there are no established exclusion criteria to defer a donor carrying malaria parasites. Therefore, based on significant independent variables identified in this study, donor malaria screening algorithm was developed to be used by blood banks to screen blood donors for subclinical malaria. Each significant variable was weighted one (1) point and its alternative response was weighted negative one (−1) point. Accumulation of the points determines the risk level of the donor. These weighted points were used to categorize infected donors as having negligible (<2 points), tolerable (3-4 points), undesirable (5–8 points), or intolerable (>9 points) risk. Based on accumulated weight of ≥5 points, the algorithm was 94.7% (54/57) sensitive but 82% (298/364) specific. With this level of specificity, 18% of the blood donors without malaria would have been deferred. Therefore, it is imperative that all donors with accumulated risk ≥5 be screened for malaria using either malaria rapid test kit or microscopy.

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“…Blood donors are screened for hepatitis B virus, hepatitis C virus, HIV, and Treponema pallidum . As the practice in Ghana, blood donors and donor blood units are not screened for malaria parasites (Aninagyei et al 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Testing was done according to the manufacturer’s protocol. Malaria parasitaemia was determined using 10% Giemsa staining; sample with parasitemia was quantified as previously published (Aninagyei et al 2021 ). This was done for both the remainders of transfused blood and pre-transfusion recipient blood.…”

Section: Methodsmentioning

confidence: 99%

Immunochromatographic and microscopic detection of Plasmodium falciparum in recipients of P. falciparum-infected donor blood

et al. 2022

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Blood transfusion practice is an essential medical intervention; however, it poses problems of transmissibility of infectious diseases including malaria. This study was designed to determine the potential of transfusion-transmitted malaria (TTM) by detecting malaria antigens and parasites in recipients of infected donor blood. After successful blood transfusion, remnants of transfused blood were screened for Plasmodium falciparum HRP2 antigen and parasitemia using CareStart malaria RDT and 10% Giemsa stain microscopy respectively according to established protocols. Recipients of microscopy detectable P. falciparum in infected blood who tested negative for malaria by both microscopy and mRDT prior to receiving infected donor blood were followed up weekly for 35 days. Donor P. falciparum antigenemia and parasitemia were 12.1% and 8.4%, respectively, while the prevalence of blood recipient parasitemia was 3.2%. Blood stored for 2–5 days recorded mean parasitemia higher than those stored for a day and after 5 days. Additionally, parasitemia was observed in all follow-up days with marginally high frequencies in days 7, 14, and 35. There was no association between the attributes (storage days, blood group, and parasite count range) of the infected donor blood units and the characteristics of blood recipients with post-transfusion parasitemia. This study provides baseline data on TTM in Ghana. However, further studies should establish the genetic relatedness of the implicated parasites since new infections and/or recrudescence of previous infections could account for this observation.

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Effect of Asymptomatic Plasmodium falciparum Parasitaemia on Platelets Thrombogenicity in Blood Donors

Cited by 6 publications

References 29 publications

Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

The Use of Screening Algorithm to Defer Blood Donors with Subclinical Malaria

Immunochromatographic and microscopic detection of Plasmodium falciparum in recipients of P. falciparum-infected donor blood

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