Effect of asymmetric force on the condylar cartilage, subchondral bone and collagens in the temporomandibular joints

Zhang, Caixia; Xu, Yue; Cheng, Yang-xi; Wu, Tuojiang; Huang, Li

doi:10.1016/j.archoralbio.2015.01.008

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…Similar but reduced alleviation was observed through the simple removal of UAC. Aberrant function‐induced cartilage degradation and subchondral bone resorption have been largely reported in the literature (Yang & Hwang, ; Zhang, Xu, Cheng, Wu, & Li, ). Mice exposed to forced mouth opening exhibit increased expression of mandibular chondrocyte maturation markers, such as collagen type II, PTHrp and sox9, and decreased subchondral bone volume (Sobue et al, ).…”

Section: Discussionmentioning

confidence: 99%

Effects of occlusion modification on the remodelling of degenerative mandibular condylar processes

Zhou

Zhang

et al. 2020

Oral Diseases

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Objective The temporomandibular joint (TMJ) displays a high remodelling capability in response to occlusion changes. The purpose of the current study was to investigate the responses of TMJ condyles of growing mice to the installation of a unilateral anterior crossbite (UAC) prosthesis and the replacement of the UAC prothesis with a bilateral anterior elevation (BAE) prosthesis. Materials and Methods C57BL/6J mice were randomly assigned to the blank control and experimental groups. In mice in the experimental groups, UAC was created, while in others, BAE was created after the creation of UAC or removal of UAC. Changes in TMJ condylar cartilage and subchondral bone were assessed. Results The degradation of condylar cartilage induced by UAC was reversed by BAE, as evaluated by cartilage histochemical changes, collagen II‐positive area, collagen X‐positive chondrocytes and expression levels of Adamts‐5, Mmp13, Tnf‐α and Il‐1β. Subchondral bone was assessed based on the subchondral bone volume, the number of TRAP‐positive cells and the Opg/Rankl ratio. Conclusion The growing mouse TMJ condyle displays a high remodelling capability, which can be degenerative or rehabilitative in response to the creation of UAC and the replacement of UAC with BAE. Early correction of occlusion is beneficial for the recovery of degenerative condyles.

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Section: Discussionmentioning

confidence: 99%

Effects of occlusion modification on the remodelling of degenerative mandibular condylar processes

Zhou

Zhang

et al. 2020

Oral Diseases

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“… Zhang.C et al 2015 [ 19 ] In vivo 232 rats CG EG Light force (1–8) EG2 heavy force (1–8) Functional over loading: Forced unilateral movements (light and heavy force for 3, 7, 14, and 28 days and rest for 3,7,14 and 28 days) Tissue response: Cartilage thickness On the loading side: EG heavy force: cartilage thickness on the anterior part of condyle decrease on the force period and increase during the recovery period, and on the medium and posterior parts the other way around EG light forces: showed the same but was not significant different Asymmetric heavy force damages the cartilage and light forces provide remodeling responses. S. Kartha et al 2016 [ 20 ] In vivo Rats (number of sample not given) CG1 CG2 EG1 EG2 Functional over loading: Forced mouth opening (7 days loading +7 rest days) CG1 = no loading EG1 = 2 N force EG2 = 3,5 N force2 Tissue response: Densitometry and IHC Cellular response: MMP-13, HIF-1α and TNF-α EG1 and EG2: showed OA like lesions EG2: ↑MMP-13, HIF-1α and TNF-α The upregulation of the cellular markers could predict the maintenance of orofacial pain and TMJ degradation. H.J.…”

Section: Resultsmentioning

confidence: 99%

“…When the same forced mouth opening protocol was applied with different intensities, light forces provided remodeling of the TMJ, while heavy forces induced degeneration and maintained an inflammatory condition [ 15 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of mechanical loading on the metabolic activity of cells in the temporomandibular joint: a systematic review

et al. 2017

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ObjectivesThe purpose of this systematic review was to elucidate how different modalities and intensities of mechanical loading affect the metabolic activity of cells within the fibro-cartilage of the temporomandibular joint (TMJ).Materials and methodsA systematic review was conducted according to PRISMA guidelines using PubMed, Embase, and Web of Science databases. The articles were selected following a priori formulated inclusion criteria (viz., in vivo and in vitro studies, mechanical loading experiments on TMJ, and the response of the TMJ).A total of 254 records were identified. After removal of duplicates, 234 records were screened by assessing eligibility criteria for inclusion. Forty-nine articles were selected for full-text assessment. Of those, 23 were excluded because they presented high risk of bias or were reviews. Twenty-six experimental studies were included in this systematic review: 15 in vivo studies and 11 in vitro ones.ConclusionThe studies showed that dynamic mechanical loading is an important stimulus for mandibular growth and for the homeostasis of TMJ cartilage. When this loading is applied at a low intensity, it prevents breakdown of inflamed cartilage. Yet, frequent overloading at excessive levels induces accelerated cell death and an increased cartilage degradation.Clinical SignificanceKnowledge about the way temporomandibular joint (TMJ) fibrocartilage responds to different types and intensities of mechanical loading is important to improve existing treatment protocols of degenerative joint disease of the TMJ, and also to better understand the regenerative pathway of this particular type of cartilage.Electronic supplementary materialThe online version of this article (doi:10.1007/s00784-017-2189-9) contains supplementary material, which is available to authorized users.

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“…They concluded that the heavier the applied force, more were the changes on the cartilage, subchondral bone and collagens of TMJ. 22 Hence, it is suggested that studies should be planned to evaluate contralateral condylar changes after distraction. While a sufficient active functional mouth opening was achieved in SAD patients in around 15.6 days, in PAD patients it took around 84.4 days.…”

Section: Discussionmentioning

confidence: 99%

Pre-arthroplastic and simultaneous mandibular distraction for correction of facial deformity in temporomandibular joint ankylosis

Chellappa

Mehrotra

Vishwakarma

et al. 2015

Journal of Oral Biology and Craniofacial Research

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a b s t r a c tIntroduction: In cases of temporomandibular joint (TMJ) ankylosis, interposition arthroplasty allows return of functional jaw movements. In order to improve the facial appearance, distraction osteogenesis is the treatment of choice, and may be timed either as a prearthroplastic, simultaneous or post-arthroplastic procedure. This study was planned to compare the treatment outcomes of pre-arthroplastic distraction (PAD) and simultaneous arthroplastic distraction (SAD) to establish the better treatment modality in terms of improvement in function and aesthetics. Materials and methods: This prospective randomized experimental study included 20 children and adolescents suffering from facial deformity due to long standing unilateral TMJ ankylosis. They were randomly allocated to the two surgical groups with ten in each group. Result: Both groups resulted in good facial symmetry and aesthetics. Initially, during the distraction period, mouth opening of SAD group scored less than that of PAD group but became comparable in 30 days. More pain at the distraction site and over the normal TMJ was observed in PAD group. The excursive movements were almost comparable in both the groups. Conclusion: We conclude that both procedures are effective in correcting the postankylotic deformity and improving function. Although PAD has better control over movement of the distracting segment, the contralateral TMJ may experience pain.SAD requires a shorter management period but is associated with a temporary decrease in function. Also, control of distraction may be difficult and chances of reankylosis are always there.

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Effect of asymmetric force on the condylar cartilage, subchondral bone and collagens in the temporomandibular joints

Cited by 19 publications

References 30 publications

Effects of occlusion modification on the remodelling of degenerative mandibular condylar processes

Effects of occlusion modification on the remodelling of degenerative mandibular condylar processes

Effect of mechanical loading on the metabolic activity of cells in the temporomandibular joint: a systematic review

Pre-arthroplastic and simultaneous mandibular distraction for correction of facial deformity in temporomandibular joint ankylosis

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