Effect of astaxanthin on ethylene glycol induced nephrolithiasis

Alex, Manju; Varghese, Mathews Valuparampil; Abhilash, M. R.; Paul, M. V. Sauganth; Nair, R. Harikumaran

doi:10.9790/3008-0714247

Cited by 1 publication

(2 citation statements)

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“…This is supported by the fact that oxalate has a central role in lithiasis pathogenesis and hypercalciuria is a threat aspect for the onset of renal calculi (Mandavia et al, 2013;Pandhare et al, 2021). This expectation is in line with Akila et al (2013) and Patel and Acharya (2020), who clarified that hypercalciuria preferred the nucleation of CaOx in urine resulted in crystal growth. As lithiasis arises by reason of urine supersaturation in that case, inequality between the stone promoters and inhibitors is established.…”

Section: Discussionmentioning

confidence: 87%

“…As lithiasis arises by reason of urine supersaturation in that case, inequality between the stone promoters and inhibitors is established. The high urinary calcium level leads to supersaturation of urinary calcium salts (Akila et al, 2013). Also, urinary pH stimulates the formation of lithiasis in various steps: including crystallization, followed by growth, and ended by aggregation and retention.…”

Section: Discussionmentioning

confidence: 99%

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Antilithiatic effect of Triticum aestivum against sodium oxalate-induced lithiasis in rat model

Sayed

2023

JoBAZ

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Background The present study pointed to evaluate the role of Triticum aestivum ethanolic extract (TAEE) in prophylactic and curative regimens on sodium oxalate (NaOx)-prompted lithiasis. Forty-eight rats were divided into the following regimen’s group (24 rats/regimen). Groups I, II, III, and IV served as prophylactic groups and divided as: group I is a vehicle control received 5% DMSO (vehicle). All the remaining groups received NaOx (70 mg/kg b.wt; i.p.). Group II is NaOx lithiatic group, groups III and IV received TAEE and cystone prophylactically at doses of 500 and 750 mg/kg b.wt, respectively, since 1st day to 7th day of lithiasis stimulation. Groups V, VI, VII, and VIII served as curative groups that divided as the prophylactic ones but TAEE and cystone administered from 7th day to 14th day of lithiasis stimulation. Results Lithiatic rats co-/post-treated with TAEE and cystone raised the urinary volume significantly. Also, TAEE showed modulatory effect in inhibiting and curative stone creation. Significant decreases were observed in the calcium and phosphate contents in urine or serum beside the increased magnesium value in lithiatic rats co-/post-treated with TAEE. TAEE significantly ameliorates the kidney function markers, which proposes its antilithiatic role. Moreover, lithiatic rats co-/post-treated with TAEE significantly diminished oxidative injury evoked by NaOx. Conclusions TAEE has antilithiatic role that may be returned to its diuretic and antioxidant activity in addition to its bioactive components including ferulic acid and phytic acid that have the inhibitory properties on crystallization calcium oxalate by lowering the content of stone promotor constituents.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%