Effect of aspirin on sugar, amino acid, and sodium transport in rat jejunum.

Aspirin inhibition of glucose absorption from the human mouth

“…There was no such effect of Ca2+ with fructose transport (Manning et al, 1978), which is independent of Na+ ions. Significantly, aspirin did not inhibit absorption of fructose across intestinal epithelium (Cooke et al, 1979). The present experiments do not discriminate between these rival theories.…”

“…The results given in Table 1 show that aspirin inhibited glucose absorption from the buccal cavity of a male human adult aged 22 years. By comparison, aspirin at 10 and 20mM inhibited transport of 40 m~-glucose across everted sacs of rat small intestine by 62 to 70% (Cooke et al, 1979). It is probable that buccal mucosa is permeable to aspirin, presumably in its un-ionized form.…”

“…Secondly, aspirin decreased significantly the net flux of Na+ ions across the epithelium of rat small intestine (Cooke et al, 1979). CaZt ions stimulated glucose transfer across the mucosa of the human mouth (McMullan et al, 1977) and rat small intestine (Manning et al, 1978).…”