Effect of aspirin on normal and cholera toxin-stimulated intestinal electrolyte transport.

Abstract

A B S T R A C T The effect of aspirin on normal and cholera toxin-stimulated electrolyte transport has been investigated in vitro, because this drug appears to inhibit cholera toxin-induced intestinal secretion in in vivo animal models. In the Ussing chamber, 10 mM aspirin decreased the control rabbit ileal potential difference and short-circuit current by 50% and increased conductance by 28%. Bidirectional electrolyte flux determinations showed that aspirin significantly increased both Na and Cl absorption and reduced the residual flux (which probably represents HCOs secretion) to zero. This effect of aspirin appears to be identical to that reported by others with catecholamines as determined with similar techniques. However, a-adrenergic blockers did not prevent the electrical effects of aspirin, suggesting that aspirin does not have its effect through release of tissue stores of catecholamines. In the presence of aspirin, cholera toxin increased the potential difference and short-circuit current, and decreased the conductance of rabbit ileum in a fashion qualitatively similar to control tissues. However, aspirin reversed cholera toxin-stimulated Na transport from secretion to absorption, inhibited cholera toxin, induced Cl secretion by 58%, and partially, but not significantly, inhibited HCOs secretion. Thus, the inhibitory effect of aspirin on cholera toxin-induced electrolyte secretion appears to be due to aspirin-stimulated Na and This work was presented in part at the American Gas-

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Prevention and Self-Treatment of Traveler's Diarrhea

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Prevention and self-treatment of travelers' diarrhea

“…The most effective of these is bismuth subsalicylate (BSS; Pepto-Bismol), which has (30). Whereas the antimicrobial effects of BSS derive from the bismuth moieties (23,110), the antisecretory and anti-inflammatory properties are likely due to the antiprostaglandin and ion channelinhibitory effects of free salicylate (46,55,59,115). When taken in the form of two 262-mg tablets four times a day with food, BSS decreased attack rates of traveler's diarrhea from 40% to 14% compared to the placebo; twice-daily dosing was less effective (36,156).…”