Effect of aspirin on gastric secretion

Lynch, Annette; Shaw, Helen M.; Milton, G. W.

doi:10.1136/gut.5.3.230

Cited by 47 publications

(9 citation statements)

References 25 publications

(16 reference statements)

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“…Previous work in these laboratories has shown that systemic absorption of large amounts of aspirin in cats inhibits the flow of gastric juice (Lynch et al, 1964), but the results obtained in the present experiments are clearly not due to absorption of large amounts of aspirin as there was no detectable loss of aspirin from the mucosal surface.…”

Section: Discussioncontrasting

confidence: 73%

“…There still remains, however, considerable doubt concerning the effects of salicylates on gastric secretory function. Some workers have reported that aspirin increases gastric acidity (Schnedorf, Bradley, and Ivy, 1936;Davison, Smith, and Smith, 1962), whereas others have reported a reduced acid output (Winkelman and Summerskill, 1961) and that gastric bleeding occurred while the acidity was very low (Lynch, Shaw, and Milton, 1964).…”

Section: Discussionmentioning

confidence: 99%

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Effect of aspirin on explanted gastric mucosa

Stephens¹,

Milton²,

Loewenthal³

1966

Gut

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Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Effect of aspirin on explanted gastric mucosa

Stephens¹,

Milton²,

Loewenthal³

1966

Gut

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“…Without this protection the mucosa becomes susceptible to injury. The administration of aspirin to cats with completely innervated, total gastric pouches produced erosions and bleeding from the stomach (9). Similar gastric changes were observed when aspirin was administered intraduodenally, thereby avoiding direct contact with the stomach.…”

Section: Some Factors Altering the Protective Effect Of Mucusmentioning

confidence: 99%

Sulfate‐containing Gastric Mucus Components and Peptic Ulcer: A Possible Relationship

Familiar¹

1969

J American Geriatrics Society

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Ulcer‐producing agents or procedures may act by interfering with the production of sulfate‐containing components of the gastric mucus. The rate‐limiting step in the production of sulfate‐containing mucus components may be the stimulated formation of phosphoadenosine phosphosulfate by vitamin A. Research is required to establish, or deny, a link between ulcerogenic agents and this sulfate activation reaction.

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“…Roth et al (25) found that gastric mucosal erosions usually developed in anesthetized cats, 2-3 h after placing an aspirin tablet in the stomach by gastrotomy. Lynch et al (19) observed gastric mucosal erosions after instillation of aspirin in the stomach of pyloroligated cats. Freening & Obrink (12) have described scanning electron microscopic changes of the cat gastric mucosal surface epithelium exposed to aspirin, namely swollen cells and incompletely broken intercellularly junctions.…”

Section: Discussionmentioning

confidence: 98%

Aspirin Damage to Ischemic Gastric Mucosa in Shocked Cats

Svanes

Leiknes

Varhaug

et al. 1979

Scandinavian Journal of Gastroenterology

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Cardiac output and blood flow to different regions and layers of the stomach were determined by the microsphere distribution technique. Aspirin tablets were placed in the stomach of anesthetized cats by gastrotomy. In some animals the arterial pressure was reduced to about 60 mmHg for 30 min by bleeding. The gastric mucosal blood flow decreased markedly during the bleeding. Three hours after reinfusion of the blood gastric mucosal erosions were present at the site of contact of the tablet with the mucosa. In most of the non-bled animals no mucosal lesions were found 4 1/2 after aspirin application. No mucosal damage occurred in animals subjected to bleeding without aspirin treatment. It is concluded that the aspirin damage to the gastric mucosa increases under hemorrhagic shock because of mucosal ischemia in the shocked animals.

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Effect of aspirin on gastric secretion

Cited by 47 publications

References 25 publications

Effect of aspirin on explanted gastric mucosa

Effect of aspirin on explanted gastric mucosa

Sulfate‐containing Gastric Mucus Components and Peptic Ulcer: A Possible Relationship

Aspirin Damage to Ischemic Gastric Mucosa in Shocked Cats

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