Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs.

Chatterjee, I. B.; Gupta, Sumanta; Majumder, A. K.; Nandi, B. K.; Subramanian, N.

doi:10.1113/jphysiol.1975.sp011091

Cited by 38 publications

(13 citation statements)

References 10 publications

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“…However, this interpretation is complicated due the ability of ascorbate to catalyze the degradation of histamine. Several early studies provided evidence of the histamine degradative potential of ascorbate (Imanaga, 1955a, 1955b; Nandi et al , 1974; Chatterjee & Gupta, 1975; Chatterjee et al , 1975; Subramanian, 1978). Uchida and colleagues later demonstrated that ascorbate degrades histamine through a selective and direct interaction at the imidazole ring (Uchida et al , 1989).…”

Section: Discussionmentioning

confidence: 99%

Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans

Romero

Ely

Sieck

et al. 2015

Experimental Physiology

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An acute bout of aerobic exercise elicits a sustained post-exercise vasodilatation that is mediated by histamine H1 and H2 receptor activation. However, the upstream signaling pathway that leads to post-exercise histamine receptor activation is unknown. We tested the hypothesis that the potent antioxidant ascorbate would inhibit this histaminergic vasodilatation following exercise. Subjects performed 1 hr unilateral dynamic knee extension at 60% of peak power in three conditions: 1) control; 2) intravenous ascorbate infusion; and, 3) ascorbate infusion plus oral H1/H2 histamine receptor blockade. Femoral artery blood flow (Doppler ultrasound) was measured before exercise and for 2 hr post-exercise. Femoral vascular conductance was calculated as flow/pressure. Post-exercise vascular conductance was greater for control condition (3.4 ± 0.1 ml min−1 mmHg−1) compared with ascorbate (2.7 ± 0.1 ml min−1 mmHg−1, P < 0.05) and ascorbate plus H1/H2 blockade (2.8 ± 0.1 ml min−1 mmHg−1, P < 0.05), which did not differ from one another (P = 0.9). Because ascorbate may catalyze the degradation of histamine in vivo, we conducted a follow-up study where subjects performed exercise in two conditions: 1) control and 2) intravenous N-acetylcysteine infusion. Post-exercise vascular conductance was similar for control (4.0 ± 0.1 ml min−1 mmHg−1) and N-acetylcysteine conditions (4.0 ± 0.1 ml min−1 mmHg−1; P = 0.8). Thus, the results in study 1 were due to the degradation of histamine in skeletal muscle by ascorbate, since the histaminergic vasodilatation was unaffected by N-acetylcysteine. Taken together, exercise-induced oxidative stress does not appear to contribute to sustained post-exercise vasodilatation.

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Section: Discussionmentioning

confidence: 99%

Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans

Romero

Ely

Sieck

et al. 2015

Experimental Physiology

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“…However, direct evidence for a causal relationship between these two parameters is lacking and it is possible that alterations in tissue AsA levels also reflect other detoxification processes during oil exposure. AsA is required for the detoxification of hstamine (Chatterjee et al, 1975). Further, AsA is important in maintaining the redox state of the cell and may act directly to reduce the superoxide anion radical generated during exposure to xenobiotics (Nishikimi, 1975).…”

Section: Discussionmentioning

confidence: 99%

Influence of some environmental variables on the ascorbic acid status of striped mullet, Mugil cephalus Linn., tissues. III. Effects of exposure to oil

Thomas¹

1987

Journal of Fish Biology

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Exposure to water‐soluble fractions (WSF) of a crude and two fuel oils altered the ascorbic acid (AsA) content of several striped mullet, Mugil cephalus, tissues. Exposure to sublethal concentrations of all three WSFs caused a depletion of AsA reserves in brain, gill, kidney and liver tissues, but not in muscle. There was a marked decline in AsA stores in kidney and gill tissues after only one day of exposure to WSFs of both crude and fuel oils. Liver AsA concentrations were significantly depleted after one week of oil exposure. Brain AsA content was only significantly depleted during chronic exposure to the highest oil concentration (20% WSF). A dose‐dependent depletion of AsA reserves in the liver but not in the other tissues was observed one week after a single exposure to 2–20% WSFs of a No. 2 fuel oil. Exposure to 20% WSF of the No. 2 fuel oil caused a 47% decrease in liver AsA content one week later. Hepatic concentrations were still significantly depleted after 15 days, but had returned to control levels 20 days after the initial exposure. The data suggest that the depletion of tissue AsA reserves in fish inhabiting oil‐contaminated environments could be sufficient on occasions to lead to AsA deficiency.

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“…It both prevents histamine release and increases the detoxification of histamine (Balz, 2003). According to Chatterjee et al (1975), other varieties of stress conditions, namely; administration of drugs, vaccines, toxoids and physical stress, the formation or release of histamine was increased in rats and guinea-pigs, and the administration of ascorbic acid resulted in detoxification of histamine in the body.…”

Section: Effect Of Vitamin C As An Antihistaminementioning

confidence: 99%

Effects of transportation and thermal stress on donkeys in the Northern Guinea Savannah zone of Nigeria: A review

Ake¹

2013

J. Cell Anim. Biol.

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The paper reviews transportation stress and its negative effects on physiological parameters of livestock, with emphasis on the Guinea Savannah zone of Nigeria. Stress factors acting on animals during road transportation are numerous and the responses of animals to them are complex, nonspecific and often detrimental to their health and productivity. In spite of the numerous recommendations and guidelines by many countries on the welfare of animal transport order and their strict compliance by transporters, several studies report severe welfare problems during road transportation of food animals. The impact of the stress on donkeys was also reviewed. It is concluded that measures to alleviate the adverse effects of road transportation stress in livestock will improve their welfare and health.

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Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs.

Cited by 38 publications

References 10 publications

Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans

Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans

Influence of some environmental variables on the ascorbic acid status of striped mullet, Mugil cephalus Linn., tissues. III. Effects of exposure to oil

Effects of transportation and thermal stress on donkeys in the Northern Guinea Savannah zone of Nigeria: A review

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