Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents

Rana, Tanmoy; Bera, Asit Kumar; Das, Soumitra; Pan, Diganta; Bandyopadhyay, S.; Bhattacharya, Debasis; De, Sumanta; Sikdar, Sourav; Das, Subrata K.

doi:10.1016/j.fct.2010.01.027

Cited by 39 publications

(21 citation statements)

References 48 publications

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“…MDA and PC are widely used as biomarkers for lipid peroxidation and protein oxidation, respectively (Rana et al, 2010). In this study, both MDA and PC contents in the muscle of grass carp fed with leucine supplemented diets were lower than those of fish fed with the leucine unsupplemented diet, indicating that leucine may prevent against oxidative damage through depressing lipid and protein oxidation in fish muscle.…”

Section: Protective Effect Of Leucine On Oxidative Damage In Musclementioning

confidence: 76%

Dietary leucine improves flesh quality and alters mRNA expressions of Nrf2-mediated antioxidant enzymes in the muscle of grass carp ( Ctenopharyngodon idella )

et al. 2016

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Section: Protective Effect Of Leucine On Oxidative Damage In Musclementioning

confidence: 76%

Dietary leucine improves flesh quality and alters mRNA expressions of Nrf2-mediated antioxidant enzymes in the muscle of grass carp ( Ctenopharyngodon idella )

et al. 2016

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“…Therefore, increasing the antioxidant capacity of cells by supplementation of few antioxidants such as vitamin C, vitamin E (Mittal & Flora, 2007;Rana et al, 2010) or some Correspondence: Prof. Mahfoud Messarah, Laboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, BP 12 Sidi Amar, Annaba, Algeria. Tel: +213-38-87-61-10.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress-related liver dysfunction by sodium arsenite: Alleviation byPistacia lentiscusoil

Klibet

Boumendjel

Khiari

et al. 2015

Pharmaceutical Biology

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Context: Pistacia lentiscus L. (Anacardiaceae) is an evergreen shrub widely distributed throughout the Mediterranean region. Pistacia lentiscus oil (PLo) was particularly known in North African traditional medicine. Thus, people of these regions have used it externally to treat sore throats, burns and wounds, as well as they employed it internally for respiratory allergies. PLo is rich in essential fatty acids, vitamin E and polyphenols. As a very active site of metabolism, liver is reported to be susceptible to arsenic (As) intoxication.Objective: The present study evaluates the protective effect of PLo against sodium arseniteinduced hepatic dysfunction and oxidative stress in experimental Wistar rats. Materials and methods: Twenty-eight rats were equally divided into four groups; the first served as a control, the remaining groups were respectively treated with PLo (3.3 mL/kg body weight), sodium arsenite (5.55 mg/kg body weight) and a combination of sodium arsenite and PLo. After 21 consecutive days, cellular functions were evaluated by hematological, biochemical and oxidative stress markers. Results: A significant decrease in the levels of red blood cells, haemoglobin (p 0.001), hematocrit (p 0.001), reduced glutathione and metallothionein (p 0.05) associated with a significant increase of malondialdehyde (p 0.001) were noticed in the arsenic-exposed group when compared to the control. The As-treated group also exhibited an increase in hepatic antioxidant enzymes namely superoxide dismutase, glutathione peroxidase (p 0.01) and catalase (p 0.05). However, the co-administration of PLo has relatively reduced arsenic effect. Conclusion: The results showed that arsenic intoxication disturbed the liver pro-oxidant/ antioxidant status. PLo co-administration mitigates arsenic-induced oxidative damage in rat.

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“…Studies have reported that deficiencies of vitamin c may cause hyperlipidaemia and liver dysfunctions [44,45] Administration with vitamin C a lowmolecular mass antioxidant, interacts directly with oxidizing radicals and protect the cell from ROS in vivo and in vitro [46] vitamin C scavenges aqueous ROS by rapid electron transfer that inhibits lipid per oxidation [47]. Coadministration of antioxidant such as vitamins C and E [48] and some essential metal such as zinc [49] during chelating therapy has been found to be beneficial in increasing arsenic mobilization and assisting the recovery of altered biochemical variable, oxidative stress is one of the important mechanisms of arsenic induced toxicity.…”

Section: Discussionmentioning

confidence: 99%

Arsenic-Induced Hepatic Toxicity and Its Attenuation by Fruit Extract of Emblica officinalis (Amla) in Mice

et al. 2013

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Arsenic a metalloid and environmental contaminated has been found to be associated with public health problems in the affected areas. It is naturally occurred in groundwater and its accumulation in plant and animals leads to toxicity in several tissues most notably hepatic organ. Arsenic exposures (3 mg/kg body weight/ day for 30 days) in mice exhibited increased arsenic and Zn levels in hepatocytes associated with enhanced oxidative stress in hepatocytes while there were no significantly changes were observed in Cu level. An increase in the lipid peroxidation and decrease in the levels of reduced glutathione and activity of superoxide dismutase, catalase, and glutathione peroxidase were observed in arsenic treated mice as compared to controls. Arsenic exposure in mice also caused a significant change in serum biomarkers in the SGOT, SGPT and creatinine as compared to the controls. There were no significant changes in the serum levels of total protein in these mice. Co-administration of arsenic and fruit extract of amla (500 mg/kg body weight/day for 30 days) caused a significant reduction of arsenic transference associated with significantly decreases hepatic arsenic levels and balanced the antioxidant enzyme and levels of serum hepatic enzymes like SGOT and SGPT. The results of the present study clearly demonstrate the antioxidant property of amla that could be responsible for its protective efficacy in arsenic induced hepatic toxicity.

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Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents

Cited by 39 publications

References 48 publications

Dietary leucine improves flesh quality and alters mRNA expressions of Nrf2-mediated antioxidant enzymes in the muscle of grass carp ( Ctenopharyngodon idella )

Dietary leucine improves flesh quality and alters mRNA expressions of Nrf2-mediated antioxidant enzymes in the muscle of grass carp ( Ctenopharyngodon idella )

Oxidative stress-related liver dysfunction by sodium arsenite: Alleviation byPistacia lentiscusoil

Arsenic-Induced Hepatic Toxicity and Its Attenuation by Fruit Extract of Emblica officinalis (Amla) in Mice

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