effect of ascorbic acid as a feed additive on indicators of the reproductive performance of Pulawska breed gilts

Lechowski, Jerzy; Kasprzyk, Anna; Tyra, M.; Trawińska, Beata

doi:10.21521/mw.5518

Cited by 5 publications

(7 citation statements)

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“…The improvement of antioxidant enzyme activity in colostrum and milk is beneficial to piglets, which contributes to the antioxidant status of piglets and thus increases the daily weight gain of piglets from birth to weaning [ 9 , 55 ]. Evidence has shown that supplementation with antioxidants, such as selenium, vitamin E and vitamin C, improves antioxidant status and reproductive performance in sows [ 11 , 55 , 56 ]. Similarly, a growing number of studies have demonstrated that certain functional substances, such as isoflavone [ 9 ], ginger extract [ 57 ] and chitosan [ 58 ], alleviate oxidative stress and improve the reproductive performance of sows.…”

Section: Discussionmentioning

confidence: 99%

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

Meng

Guo

et al. 2018

J Animal Sci Biotechnol

118

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BackgroundResveratrol, a plant phenol, affords protection against inflammation and oxidative stress. The objective of this study was to investigate the effects of dietary resveratrol supplementation during pregnancy and lactation on the antioxidant status of sows and piglets and on antioxidant gene expression and pathway in placenta.MethodsForty sows were allotted to 2 dietary treatments 20 d after breeding. Sows were fed a control diet and a control diet with 300 mg/kg resveratrol. Oxidative stress biomarkers and antioxidant enzymes were measured in the placenta, milk, and plasma of sows and piglets. Antioxidant gene expression and protein expression of Kelch-like ECH-associated protein 1-Nuclear factor E2-related factor 2 (Keap1-Nrf2), nuclear factor kappa B-p65 (NFκB-p65) and sirtuin1 (Sirt1) were quantified in the placenta.ResultsDietary resveratrol increased the litter and piglets weaning weights. Antioxidant status in the milk, placenta and plasma of sows and piglets was partially improved by dietary resveratrol. In placenta, Nrf2 protein expression was increased and Keap1 protein expression was decreased by dietary resveratrol. The mRNA expression of antioxidant genes including catalase (CAT), glutathione peroxidase 1 (GPX1), GPX4, superoxide dismutase 1 (SOD1) and heme oxygenase 1 (HO1), and phase 2 detoxification genes, including glutamate-cysteine ligase modifier (GCLM), microsomal glutathione S-transferase 1(MGST1) and UDP glucuronosyltransferase family 1 member A1 (UGT1A1), was increased by dietary resveratrol. Dietary resveratrol also increased Sirt1 and phosphorylated NFκB-p65 protein expression in the placenta. We failed to observe any influences of dietary resveratrol on pro-inflammatory cytokine levels, including those of interleukin 1β (IL-1β), IL-6, IL-8 and tumor necrosis factor α (TNF-α). However, we observed that the mRNA expression of IL-8 in placenta was reduced by maternal resveratrol. In addition, dietary resveratrol showed interactive effects with day of lactation on activities of SOD and CAT and levels of malonaldehyde (MDA) and hydrogen peroxide (H2O2) in milk.ConclusionsDietary resveratrol supplementation during pregnancy and lactation improves the antioxidant status of sows and piglets, which is beneficial to the reproductive performance of sows. Dietary resveratrol regulates placental antioxidant gene expression by the Keap1-Nrf2 pathway and Sirt1 in placenta.

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Section: Discussionmentioning

confidence: 99%

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

Meng

Guo

et al. 2018

J Animal Sci Biotechnol

118

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“…Levine et al (1996) reported that vitamin C elevates the protein content in plasma by altering serum total protein components and ratio. Lechowski et al (2015) proved this by an increased level of protein in colostrum, milk and also increased fat components. This improves the survivability of piglets by facilitating rapid growth and development.…”

Section: Introductionmentioning

confidence: 83%

“…The antioxidant properties of vitamin C and the potential against oxidative stress and infection have been established in livestock. It is also important under other stressful conditions like heat, weaning, parturition and lactation (Lechowski et al, 2015;Ahmadu et al, 2016). It was previously thought for many years that pigs are able to synthesize enough vitamin C, however, their deficiency has been proved to be unsafe (Ching et al, 2001;Kolb and Seehawer, 2001;Lauridsen and Jensen, 2005;Chung, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin C (Ascorbic Acid) Supplementation on Growth Performance, Economic Indices, Haematology, Serum Biochemistry and Carcass Characteristic of Weaner Pigs

OJEDIRAN,

AJEWOLE,

TAIWO

et al. 2022

Slovak J. Anim. Sci.

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Seven weeks old weaned pigs (Yorkshire x Landrace, n = 32, mean weight = 12.32 ± 0.59 kg) were allotted to 4 treatments (diets) consisting of 8 replicates each: diet A − basal diet; diet B − basal + ascorbic acid at 1 g.kg-1 diet; diet C − basal + ascorbic acid at 2 g.kg-1 diet; and diet D − basal + ascorbic acid at 3 g.kg-1 diet. Growth performance, economic indices, haematological parameters, serum biochemistry and carcass characteristics were measured. After 49 days, the pigs on diet with ascorbic acid at 2 g.kg-1 had significantly higher daily feed intake (1.54 kg per pig) (p < 0.05). The feed cost per kg increased significantly (p < 0.05) across the diets from the control (Nigerian naira, ₦ 97.60) to basal + ascorbic acid at 3 g.kg-1diet (₦ 103.50). Significantly higher (p < 0.05) red blood cell, haemoglobin, haematocrit and mean corpuscular volume values were recorded in pigs fed ascorbic acid at 2 g.kg-1 diet, while pigs fed ascorbic acid at 3 g.kg-1 diet had the highest cholesterol, triglyceride, glucose, creatinine, urea, total protein and globulin (p < 0.05) levels. Pigs offered ascorbic acid had significantly higher bleed weight, carcass weight, belly, abdominal fat, back fat thickness and whole and empty stomach weight than those fed the control diet. It can be concluded that vitamin C supplementation (up to 3 g.kg-1) had no negative impact on the growth performance and economic indices (except the feed cost) of the pigs, while it improved the haematological parameters and carcass weight and also enhanced fat deposition.

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“…Nevertheless, a positive subsequent impact of the vitamins provided to sows was noted: a combination of vitamin E and C significantly lowered the body temperature of sows following farrowing and notably decreased the number of sows culled after rearing [125]. A study by Lechowski et al (2016) demonstrates that vitamin C supplementation in gilts and sows improves reproductive performance. This included an increase in the number of corpora lutea and the synthesis of 17b-estradiol.…”

Section: Vitamin Cmentioning

confidence: 99%

The Role of Vitamins in Mitigating the Effects of Various Stress Factors in Pigs Breeding

Smołucha,

Steg,

Oczkowicz

2024

Animals

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Good practices in farm animal care are crucial for upholding animal well-being, efficiency, and health. Pigs, like other farm animals, are exposed to various stressors, including environmental, nutritional, chemical, psychological, physiological, and metabolic stressors, which can disrupt their internal balance and compromise their well-being. Oxidative stress can adversely affect animal performance, fertility, and immunity, leading to economic losses for farmers. Dietary considerations are hugely important in attaining these objectives. This paper reviews studies investigating the impact of additional vitamin supplementation on stress reduction in pigs. Vitamin A can be beneficial in counteracting viral and parasitic threats. Vitamin B can be a potential solution for reproductive issues, but it might also be beneficial in reducing the effects of inappropriate nutrition. Vitamin C plays a vital role in reducing the effects of heat stress or exposure to toxins in pigs. Vitamin D proves to be beneficial in addressing stress induced mostly by infections and weaning, while vitamin E has been shown to mitigate the effects of toxins, heat stress, or transport stress. This review highlights the potential benefits of these dietary antioxidants in maintaining pig health, enhancing productivity, and counteracting the adverse effects of various stressors. Understanding the role of vitamins in pig nutrition and stress management is vital for optimising farm animal welfare and production efficiency.

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effect of ascorbic acid as a feed additive on indicators of the reproductive performance of Pulawska breed gilts

Cited by 5 publications

References 18 publications

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

Effect of Vitamin C (Ascorbic Acid) Supplementation on Growth Performance, Economic Indices, Haematology, Serum Biochemistry and Carcass Characteristic of Weaner Pigs

The Role of Vitamins in Mitigating the Effects of Various Stress Factors in Pigs Breeding

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