Effect of Ascorbic Acid and &lt;i&gt;Allium Sativum&lt;/i&gt; on Tissue lead Level in Female &lt;i&gt;Rattus Navigicus&lt;/i&gt;

Adeniyi, T. T.; Ajayi, G. O.; Akinloye, O. A.

doi:10.4314/njhbs.v7i2.11675

Cited by 10 publications

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“…VC has also been reported to protect the cells and sperm from oxidative stress and loss of motility, respectively [37]. VC inhibits lipid peroxidation, regenerate spent VE and protects against hydrogen peroxide induced DNA damage [15]. …”

Section: Discussionmentioning

confidence: 99%

“…Vitamins A, E, D and C were reported to possess antioxidant functions, and their inhibitory effects on ROS accumulation vary from one vitamin to the other [14]. L-Ascorbic acid (Vitamin C) is a water soluble vitamin derived from dietary sources such as fruits and vegetables [15]. Vitamin C (VC) plays an efficient protective role directly or indirectly in a systemic detoxification of Pb [16].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats

Ayinde

Ogunnowo

Ogedegbe

2012

BMC Pharmacol Toxicol

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BackgroundOccupational and environmental exposures to lead remain a public health problem as lead alters physiological processes by inducing oxidative stress and mimicking divalent cations. This study was designed to investigate the effects of Vitamin C (VC) and Vitamin E (VE) on the reproductive function of lead exposed male rats. Experimental animals were exposed to oral doses of lead, VC and VE at 60 mg/kg body weight, 40 mg/kg body weight, and 150 mg/kg body weight respectively, while control animals received 0.9% saline solution. Oral administration spanned for six weeks after which changes in testicular redox status, lead deposition, testicular zinc content, serum androgen content, semen quality and testis histology were examined.ResultsThere were significant (p < 0.05) increases in oxidative stress indices and testicular lead content. A significant (p < 0.05) depletion of zinc in the testis of lead exposed animals was also observed. Fluctuations were observed in androgen levels of lead treated animals with a significant increase (p < 0.05) in Serum follicle stimulating hormone (FSH) and testosterone (TT) content, while there was no significant change in luteinizing hormone (LH) content. Testicular tissue showed an alteration in its normal histology with degeneration of the seminiferous epithelium accompanied by a significant reduction (p < 0.05) in the number of luminal spermatozoa. A downgrade in the semen appearance and semen quality –sperm motility, morphology, and count was also observed after lead exposure. VC and VE treatment showed a significant (p < 0.05) reversal of the physiological alteration induced by lead.ConclusionsLead exposure resulted in a decline in the reproductive function of male rats by inducing oxidative stress, inhibiting enzymes and depleting testicular zinc contents. However, results clearly showed that VC and VE attenuated the deleterious impact of lead on the reproductive system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats

Ayinde

Ogunnowo

Ogedegbe

2012

BMC Pharmacol Toxicol

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“…Levels of lead in soft tissue appear to be relatively constant during life, despite a fairly high turnover rate (Barry, 1975). Lead is stored in almost all soft tissues (Doyle and Younger, 1984); autopsy studies show that liver is the largest repository of soft tissue lead (33%), followed by kidney cortex and medulla, pancreas, ovary, spleen, prostate, adrenal gland, brain, fat, testis, heart, and skeletal muscle (Senapati et al, 2001;Adeniyi et al, 2008;Sharma et al, 2011b, c;Sharma et al, 2011). Dose related accumulation of most lead in heart and kidney in new born rat pups was reported by Singh et al (1976).…”

Section: Effect Of Lead In Soft Tissuementioning

confidence: 99%

“…However, both occupational and environmental exposure has made lead a serious problem in many developing and industrializing countries (Yucebilgic et al, 2003). It has many undesired effects, including neurological (Senapati et al, 2001;Soltaninejad et al, 2003;Bellinger, 2008;Sharma et al, 2011), behavioural (Moreira et al, 2001;De Marca, 2005;Adeniyi et al, 2008), immunological (Razani-Boroujerdi et al,1999;Bunn et al, 2001;Rosenberg et al, 2007), renal (Lockitch, 1993;Vargas et al,2003;Rastogi, 2008;Sharma et al, 2011c), hepatic (Lockitch, 1993;Patra et al, 2001;Sharma et al, 2011b), cardiovascular system and haematological dysfunctions (Mousa et al,2002;Adeniyi et al, 2008). Lead pollution can also cause irreversible encephalopathy, seizure, coma and even death.…”

Section: Introductionmentioning

confidence: 99%

Lead toxicity, oxidative damage and health implications. A review

Sharma¹,

Sharma²,

Paliwal³

et al. 2011

Int. J. Biotechnol. Mol. Biol. Res.

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The toxicity of Lead was recognized centuries ago, and it continued to pose serious threat to the health of children as well as adults. This review presents an overview of the current knowledge of toxic effects of Lead induced oxidative damage and also suggests some possible measures which could reduce the toxic effects of the metal. This paper examines the effects of Lead in blood, soft tissues, haematopoietic system and the antioxidant defense system. On the other hand, data also indicated that lead is an essential element at low dietary intakes. Its deficiency was shown to depress growth, disturb iron metabolism, alter activities of some enzymes and disturb the metabolism of cholesterol, phospholipids and bile acids. It was found that lead toxicity is significant but a preventable health problem. Furthermore, work is needed to find the effective and safe intervention for lowering the lead exposure at the general population level.

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“…Lead exposure produce reversible changes in mood and personality as fatigue, irritability, depression etc [2]. It causes a number of undesirable changes including neurological [3][4], behavioural [5][6], immunological [7][8], renal [9][10][11], hepatic [12], cardiovascular system and hematological dysfunctions [13,6]. Children which are exposed to lead are reported to have adverse effects on central nervous system and kidneys [14].…”

Section: Introductionmentioning

confidence: 99%

Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load

Rai¹

2015

ABB

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A significant decrease in weight of ovary and oviduct of female rats was noted following lead nitrate administration with a dose 80 mg/kg body weight/day for 28 days. Histomicrogaphs of ovary showed marked inhibition of follicular growth as judged by gradual decrease oocyte size, absence of theca and granulosa layer, resulting absence of graafian follicle. Oviduct showed shrinkage in lumen and damage in perimetrium cells. Increase in total protein of ovary and oviduct after lead nitrate treatment denoting changes at translational level of concern gene to prevent the normal physiology. A significant increase in the thiobarbituric acid reactive substances (TBARS) of both tissues denotes increased free radical load resulted in the damage of cellular architecture. Findings, suggest that lead entering to the biological system via environment and other widely used industrial product may interfere with the normal reproductive physiology and folliculogenesis could be one of the cause of female infertility.

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Effect of Ascorbic Acid and <i>Allium Sativum</i> on Tissue lead Level in Female <i>Rattus Navigicus</i>

Cited by 10 publications

References 0 publications

Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats

Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats

Lead toxicity, oxidative damage and health implications. A review

Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load

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